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1.
Klin Lab Diagn ; (2): 54-61, 2013 Feb.
Artigo em Russo | MEDLINE | ID: mdl-23808013

RESUMO

The results of implementation of different clinical laboratory techniques are to be equal in clinically significant limits to be optimally applied in diagnostics of diseases and treatment of patients. When the results of laboratory tests are not standardized and harmonized for the very same clinical assay the results can be expressed by unmatched numbers. Unfortunately, in some handbooks the values are presented based on the results of application of specific laboratory techniques without considering possibility or likelihood of differences between various techniques. When this is a case, accumulation of data of diferent clinical research studies and working out of clinical handbooks on this basis will be inconsistent. Inadequate understanding of issue that the results of laboratory tests are not standardized and harmonized can lead to incorrect clinical, financial, managerial or technical decisions. The standardization of clinical laboratory techniques was applied to many measurands related to primary referent techniques (standard specimen of pure substance) or/and developed referent measurement techniques. However, harmonization of clinical laboratory techniques for those measurands which are not related any developed measurement techniques is quite problematic due to inadequate determination of measurand, its inadequate analytical specificity, insufficient attention to commutability of referent materials and poor systematic approach to harmonization. To overcome these issues an infrastructure is to be developed to support systematic approach to identification and prioritization of measurands which are to be harmonized on the basis of clinical importance and technical applicability. The management of technical implementation harmonization process for specific measurands.


Assuntos
Testes de Química Clínica/normas , Técnicas de Laboratório Clínico/normas , Erros de Diagnóstico/prevenção & controle , Controle de Qualidade , Padrões de Referência , Reprodutibilidade dos Testes , Gestão da Qualidade Total
2.
Atherosclerosis ; 108 Suppl: S157-69, 1994 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-7802722

RESUMO

The lipid and lipoprotein parameters which are predominantly measured and effectively comprise the traditional lipoprotein profile include total cholesterol, high density lipoprotein (HDL) cholesterol, low density lipoprotein (LDL) cholesterol, and triglyceride. Total cholesterol is accepted as the initial entry point in a case finding approach such as that recommended by the National Cholesterol Education Program (NCEP). HDL cholesterol, known to be a strong inverse predicator of risk, is an additional measurement to total cholesterol to improve risk assessments. The evidence for triglyceride association remains mixed: although strong associations are found in some studies, the evidence as an independent risk factor is still incomplete. Triglyceride is therefore measured primarily for LDL estimation. Final classification and potential intervention is ultimately based on the measurement of LDL cholesterol. Reliability in the measurement of total cholesterol, HDL, LDL, and triglyceride is especially important if the uniform decision points established by the NCEP are to be properly implemented. Attention must be placed on controlling preanalytical sources of variation, which can account for as much as 60% of the total measurement variability. The major analytical source of error comes from matrix effects, which results in problems of proper analytical calibration. Instrument system calibration should be verified by a comparison with an accuracy base using fresh patient specimens. CDC has established a network of reference method laboratories to provide access to these lipid and lipoprotein accuracy bases.


Assuntos
Doença das Coronárias/etiologia , Lipoproteínas/sangue , Doença das Coronárias/sangue , Humanos , Lipídeos/sangue , Fatores de Risco
3.
Pediatrics ; 70(1): 36-42, 1982 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-7088631

RESUMO

Seven children and adolescents (aged 8 to 23 years, mean 16 years) with poorly controlled insulin-dependent diabetes mellitus were evaluated with a glucose-controlled insulin infusion system (GCIIS) to determine whether its use could help define appropriate long-term insulin treatment regimens and increase patient understanding and compliance with such regimens. The GCIIS-derived insulin regimen was characterized by a mean insulin requirement of 1.0 +/- 0.1 units/kg/day, with 55% of the total insulin dose given in the morning and 45% in the evening. Forty-eight percent of the total insulin was short acting. Both clinical and biochemical indices of metabolic control (HbA1c levels) improved after insulin dose readjustment based on GCIIS data. The continuous documentation of blood glucose levels provided by the GCIIS was valuable in educating patients about the interrelationship between insulin, exercise, and diet. Using GCIIS data, patients were taught to apply the new regimen flexibly to variations in activity and diet. Thus, the GCIIS can aid in the management of selected children and adolescents with insulin-dependent diabetes millitus. Insulin patterns derived from its use suggest that a flexible, twice daily regimen characterized by nearly equal proportions of short- and intermediate-acting preparations may be beneficial for other pediatric patients.


Assuntos
Diabetes Mellitus Tipo 1/tratamento farmacológico , Sistemas de Infusão de Insulina , Adolescente , Adulto , Glicemia/análise , Criança , Diabetes Mellitus Tipo 1/sangue , Diabetes Mellitus Tipo 1/diagnóstico , Feminino , Humanos , Masculino
4.
J Biomed Sci ; 2(2): 90-104, 1995 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-11725046

RESUMO

Papillomaviruses are responsible for a variety of diseases in humans and animals, ranging from harmless skin warts to lethal cancers. They also make up one of the most genetically diversified families of viruses known, and could represent a model system of DNA-virus evolution. A specialized genetic sequences database, The Human Papillomavirus Database and Analysis Project, was recently established in an effort to provide database services that are specific to papillomaviruses to the research community and to perform a variety of sequence-based analyses. This review is intended to present the scope of the information currently contained in the database and to outline some of the analyses that have been performed on the genetic sequences. These analyses will address issues including phylogenetic relationships, recombination events, selective pressures on different genes and the possibility of cross-species transmission in the case of the papillomaviruses. Copyright 1995 S. Karger AG, Basel

5.
Metabolism ; 34(4): 330-5, 1985 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-3884963

RESUMO

The cause of insulin resistance in lipodystrophic diabetes is unknown but has generally been ascribed to dysfunction at either the receptor or post receptor level. In a 14 year-old girl with total acquired lipodystrophy, subcutaneous and intravenous insulin requirements approximated 600 units daily. However, circulating total and free insulin levels were not increased, and during testing by the euglycemic clamp method, the glucose response to increasing free insulin concentrations was within the range found in eight subjects with insulin-dependent diabetes. Insulin clearance during the euglycemic clamp was 43, 98, 115, and 116 mL/kg/min at each of four insulin infusion rates compared to means of 13, 13, 12, and 11 in the control subjects with diabetes. No detectable degrading activity was present in serum, and serum inhibited insulin degradation normally. Binding of insulin to IgG, IgM, and IgE was not increased, insulin binding to monocytes and erythrocytes was not sufficiently abnormal to account for the the insulin resistance, and insulin receptor increased insulin clearance or accelerated degradation of insulin by tissues.


Assuntos
Diabetes Mellitus Lipoatrófica/sangue , Resistência à Insulina , Adolescente , Eritrócitos/metabolismo , Feminino , Humanos , Imunoglobulinas/metabolismo , Insulina/sangue , Taxa de Depuração Metabólica , Monócitos/metabolismo , Ligação Proteica , Receptor de Insulina/metabolismo
6.
Diabetes Technol Ther ; 1(4): 403-9, 1999.
Artigo em Inglês | MEDLINE | ID: mdl-11474824

RESUMO

In 1997, the Centers for Disease Control and Prevention established the National Diabetes Laboratory in order to help prevent and treat type 1 diabetes. This state-of-the-art laboratory collaborates with research scientists and key national and international organizations throughout the world to identify and study risk factors for type 1 diabetes by developing measurements for glycosylated proteins, developing and evaluating technology for measuring genetic risk factors for the disease, and working to standardize autoantibody measurements. Developing improved technologies for diagnosing and managing diabetes and developing reference materials for properly calibrating and standardizing blood glucose meters are also critical aspects of the laboratory's work. In addition, the laboratory provides quality storage for valuable collections of biologics and other materials and facilitates sharing of specimens, associated epidemiologic data, and test results. Working with our partners in diabetes research, we are improving the diagnosis, treatment, and prevention of type 1 diabetes.


Assuntos
Centers for Disease Control and Prevention, U.S. , Diabetes Mellitus Tipo 1/prevenção & controle , Diabetes Mellitus Tipo 1/terapia , Autoanticorpos/sangue , Automonitorização da Glicemia/normas , Diabetes Mellitus Tipo 1/epidemiologia , Diabetes Mellitus Tipo 1/genética , Métodos Epidemiológicos , Hemoglobinas Glicadas/análise , Humanos , Monitorização Fisiológica/métodos , Controle de Qualidade , Fatores de Risco , Estados Unidos/epidemiologia
7.
Clin Lab Med ; 9(1): 105-35, 1989 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-2538292

RESUMO

In collaboration with the National Heart, Lung, and Blood Institute, the CDC has supported programs for standardizing lipid measurements for more than 30 years. These programs were begun because comparable and accurate quantitative measurements were needed for epidemiologic studies of coronary heart disease. Since the first program was initiated, over 500 national and international laboratories have participated in the various CDC lipid standardization programs. The cornerstone of these standardization programs has been an accuracy base of lipid reference materials and methods developed by CDC. Specifically, CDC has developed human, serum-based reference materials for cholesterol, HDL, triglyceride, and apolipoproteins A-I and B and reference methods for total cholesterol, HDL, and triglyceride. The CDC reference method for cholesterol has been adopted as the national reference method for cholesterol by the National Reference System for the Clinical Laboratory Council of the National Committee for Clinical Laboratory Standards. The approved CDC reference method along with an approved NBS definitive method, an approved NBS certified Reference Material, and the CDC certified serum-based secondary reference materials make up the accuracy base for serum cholesterol measurements in the United States, and together they are recognized as the National Reference System for Cholesterol. The NCEP Laboratory Standardization Panel recommends that cholesterol measurements made by all clinical laboratories should be standardized so that cholesterol values are traceable to the National Reference System for Cholesterol. In support of the NCEP's efforts, CDC will establish a standardization program permitting the laboratory and manufacturing community to trace cholesterol measurements and the development of cholesterol diagnostic products back to the national reference system. The major emphasis of this standardization effort is to establish a network of reference method laboratories (1) to assign cholesterol values to all commercially prepared lots of calibrators and control materials and (2) to provide reference measurements on individual "fresh" human serum specimens to manufacturers and clinical laboratories. CDC is also working to (1) provide reference materials to manufacturers, (2) collaborate with NBS to maintain documentation of the national reference system accuracy base, (3) cooperate with proficiency testing organizations to assist in the accurate labeling of reference materials, and (4) provide training and education pertinent to cholesterol standardization.(ABSTRACT TRUNCATED AT 400 WORDS)


Assuntos
Centers for Disease Control and Prevention, U.S. , Laboratórios/normas , Lipídeos/sangue , Humanos , National Institutes of Health (U.S.) , Padrões de Referência , Estados Unidos
8.
J Endod ; 17(6): 275-9, 1991 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-1940753

RESUMO

Sixty extracted human teeth were divided into three groups of 20 each. Apically extruded debris and irrigant were collected, dried, and weighed by the following three instrumentation techniques: (a) group 1, filing 1 mm short of the foramen; (b) group 2, Canal Master instrumentation to the foramen; and (c) group 3, filing to the foramen (for a relative comparison). The results indicated that all three groups were significantly different from one another. Group 1 had the least amount of debris extruded. Of the two groups instrumented to the foramen, group 3 had twice as much debris extruded as group 2. An apical dentinal plug was frequently found in group 1 and was probably a major reason why this group had the least amount of extruded debris. The significance of this dentinal plug and possible indications for instrumentation to the foramen are discussed.


Assuntos
Preparo da Cavidade Dentária/métodos , Infiltração Dentária , Tratamento do Canal Radicular/métodos , Análise de Variância , Preparo da Cavidade Dentária/instrumentação , Humanos , Tratamento do Canal Radicular/instrumentação
9.
Arch Pathol Lab Med ; 122(7): 587-608, 1998 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-9674541

RESUMO

CONTEXT: Better procedures are needed whereby national proficiency testing survey providers can assess and improve the accuracy of laboratory measurements in clinical chemistry. SETTING: The 1994 College of American Pathologists Comprehensive Chemistry Survey. DESIGN: This study of matrix effects and the accuracy of laboratory measurements for 11 analytes linked the logistics of the Survey to definitive methods at the National Institutes of Standards and Technology, reference methods at the Centers for Disease Control and Prevention, proficiency testing materials, and a fresh frozen serum sample. The data were analyzed with a statistical model of laboratory measurements. RESULTS: (1) Matrix biases affected the results reported from 69% of the 644 peer group/survey specimen pairs evaluated. (2) Because of matrix biases, the reference value was the correct target value only 32% of the time; thus, the traceability established by definitive method and reference method value assignments on Chemistry Survey specimens did not assure accuracy on patient samples. (3) In contrast to matrix biases, the error caused by random matrix effects with proficiency testing samples was about the same as that caused by random specimen effects with fresh frozen serum, and both were less than within-run random analytic error. (4) Calibration biases occurred in 73% of the 180 peer groups evaluated, and, after matrix biases were removed, the total variance of interlaboratory measurements was due to peer group calibration bias (48%), within-peer-group random calibration error (31 %), within-run random error (14%), and random specimen effects (7%). CONCLUSIONS: An opportunity exists to improve method calibration accuracy in clinical chemistry. With improved design, national proficiency testing surveys can monitor and help reduce method calibration error by converting reported survey results to a true accuracy base that predicts accuracy on patient samples. For medical purposes, the correct target values on artificial (matrix-modified) chemistry materials are reference values adjusted for the matrix bias of each peer group. Matrix biases estimated by the use of fresh frozen serum can be used as factors to transfer the accuracy of definitive methods from artificial reference materials to patient samples.


Assuntos
Análise Química do Sangue/normas , Química Clínica/normas , Laboratórios/normas , Controle de Qualidade , Viés , Sangue , Análise Química do Sangue/métodos , Análise Química do Sangue/estatística & dados numéricos , Calibragem , Química Clínica/estatística & dados numéricos , Criopreservação , Humanos , Valores de Referência , Sensibilidade e Especificidade
10.
Arch Pathol Lab Med ; 117(4): 393-400, 1993 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-8466403

RESUMO

We found evidence of bias due to matrix effect in 70% of 37 instrument/reagent-specific systems analyzing the total cholesterol content of a lyophilized proficiency testing material. We used a computational method to remove bias due to matrix effect from the proficiency testing database. After correction for matrix effect bias and when compared with the reference method, 92% to 93% of results for three lyophilized proficiency testing samples analyzed in 1989 and 1990 met the 1992 National Cholesterol Education Program total error goal of 8.9%, and 94% to 95% met the Clinical Laboratory Improvement Amendments of 1988 (CLIA '88) goal of 10%. However, compared with the definitive method for total cholesterol, the calibration bias of 41% of 37 peer groups exceeded the 1992 National Cholesterol Education Program goal for bias of 3%. Because the calibration bias of the method is incorporated into the peer group mean, use of peer group means as target values to assess result acceptability hinders advancement of the state of the art in interlaboratory comparability and the clinical effectiveness of laboratory testing. The prevalence of matrix effects has prevented successful application of accuracy-based evaluation of cholesterol test proficiency. The establishment of predictable recovery, preferably complete recovery, of cholesterol from reference materials is an important priority for cholesterol test methods. However, adjustment of proficiency testing results to remove the average bias due to matrix effects can help assess the actual state of the art in cholesterol test accuracy.


Assuntos
Viés , Química Clínica/normas , Colesterol/sangue , Garantia da Qualidade dos Cuidados de Saúde , Padrões de Referência , Análise Química do Sangue/normas , Coleta de Amostras Sanguíneas , Coleta de Dados , Humanos , Laboratórios/normas , Reprodutibilidade dos Testes
11.
Arch Pathol Lab Med ; 119(8): 686-94, 1995 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-7646324

RESUMO

OBJECTIVE: To evaluate the suitability of various commercial preparations for use by the College of American Pathologists as survey materials in assessing high-density lipoprotein cholesterol measurement performance. DESIGN: Lyophilized human serum preparations from six vendors (vendors A through F) were evaluated to determine which material(s) best mimicked the commutability of fresh human serum. Two freshly collected unfrozen pools prepared from donor specimens were analyzed concurrently with the vendor materials to identify sources of variation and possible matrix bias. Each material was evaluated using 5 common precipitation reagents (phosphotungstate-magnesium, phosphotungstic acid, dextran sulfate [50K and 500K], and heparin-manganese). To evaluate how each reagent separates lipoproteins in each material, the lipoprotein separation patterns were profiled using high-pressure liquid chromatography and compared with separation patterns observed for the fresh human serum pools. MAIN OUTCOME MEASURES: Similarities in performance characteristics of vendor material(s) were compared with fresh human serum. RESULTS: Two of the six materials gave separation profiles for the lipoproteins similar to the typical patterns observed for human serum. Material from vendor B showed the best commutability across all of the precipitation reagents and had the best combination of low overall variability (10% for level 1 and 9.4% for level 2) and minimal concentration differences among reagents. CONCLUSIONS: Vendor B was selected by the College of American Pathologists to provide materials for use in assessing performance of lipid and lipoprotein testing in the 1994 Comprehensive Chemistry Surveys. This study demonstrates the great variability that different vendor preparations introduce into the measurement of high-density lipoprotein cholesterol. It also emphasizes the effort required to evaluate the suitability of processed materials for use in proficiency testing.


Assuntos
HDL-Colesterol/sangue , Liofilização , Testes Hematológicos/normas , Garantia da Qualidade dos Cuidados de Saúde , Manejo de Espécimes/métodos , Análise de Variância , Cromatografia Líquida de Alta Pressão , Humanos , Lipoproteínas/sangue , Concentração Osmolar , Projetos Piloto
12.
Arch Pathol Lab Med ; 114(12): 1199-205, 1990 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-2252414

RESUMO

Several recent studies to evaluate the performance of laboratory instruments have shown that with some instrument systems processed (lyophilized, frozen, and stabilized) materials exhibit matrix effects that cause the assay for cholesterol to respond differently for them than for patient specimens. To understand this phenomenon better the College of American Pathologists, Northfield, III, and the Centers for Disease Control, Atlanta, Ga, have conducted a collaborative study with 44 laboratories where 16 instruments manufactured by nine companies are evaluated. The purposes were to assess measurement variation on several reference materials used for standardizing total cholesterol measurements and to evaluate a new stabilized liquid serum as a potential reference material. Lypophilized, frozen, fresh-frozen, and stabilized materials at three concentrations were measured for total cholesterol. The results show that the average coefficient of variation of measured total cholesterol for all instruments, laboratories, vials, and replicates is 3.6% to 4.1% for each of the materials measured (excluding the results for one instrument). For one instrument, however, significant bias was found on the stabilized liquid serum material. Results from the fresh-frozen materials indicate that the instrument systems evaluated allow laboratories to attain the National Cholesterol Education Program analytical performance goals.


Assuntos
Colesterol/sangue , Técnicas de Laboratório Clínico/normas , Análise de Variância , Técnicas de Laboratório Clínico/instrumentação , Humanos , Padrões de Referência
13.
Arch Pathol Lab Med ; 117(4): 345-51, 1993 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-8466396

RESUMO

The objective of this collaborative study with the Department of Veterans Affairs (VA), College of American Pathologists (CAP), and the Centers for Disease Control and Prevention (CDC) was to quantitate the matrix-induced biases of cholesterol measurements on the CAP Comprehensive Chemistry Surveys materials used in proficiency testing (PT). A total of 174 VA Medical Centers outpatient clinics and clinical laboratories participate in the VA-CDC National Cholesterol Standardization and Certification Program. This study was conducted in 112 VA laboratories that have been standardized for measuring cholesterol accurately (within +/- 3.0% of the CDC reference-method values) using fresh, unfrozen, unadulterated human serum samples. Fresh serum samples and 1990 CAP Surveys materials were sent by overnight mail, and the laboratories were asked to analyze them simultaneously in triplicate in a single analytic batch run. The results showed significant matrix-effect biases with the CAP Surveys materials with six of the eight major peer groups, despite the fact that accuracy of cholesterol measurements was maintained with fresh serum samples. The magnitude and direction (positive or negative) of the matrix-effect biases were instrument, reagent, and method specific using the following peer groups: du Pont Dimension (-8.9%); Beckman CX4, CX5, and CX7 (-5.5%); Kodak Ektachem 400, 500, and 700 (+4.4%); Instrumentation Laboratory Monarch (-3.1%); Baxter Paramax (-2.4%); Technicon SMAC and RA (+1.3%); Hitachi/BMD 704 through 747 (+0.4%); and Abbott Spectrum (-0.3%). The CAP PT materials used currently do not behave in a manner identical to fresh human serum when measuring cholesterol on many, but not all, analytic systems. The observed biases due to "matrix effects" with PT materials will cause incorrect conclusions about the accuracy of many laboratory procedures performed on fresh patient specimens. This matrix-effect phenomenon will severely hamper interlaboratory accuracy transfer, standardization efforts, and monitoring performance of a laboratory's testing accuracy with the use of the current survey materials used in PT programs. Collaborative efforts are needed to (1) improve PT fluids to analytically behave more like fresh, human serum; (2) improve instrument design and reagent formulation; and (3) select methods and methodologic parameters that are more "robust" and less sensitive to the exact character of processed calibrators, quality control, and PT materials.


Assuntos
Viés , Química Clínica/normas , Colesterol/sangue , Laboratórios Hospitalares/normas , Garantia da Qualidade dos Cuidados de Saúde , Padrões de Referência , Análise Química do Sangue/normas , Coleta de Amostras Sanguíneas , Hospitais de Veteranos , Humanos , Análise de Regressão , Reprodutibilidade dos Testes , Estados Unidos
14.
Artigo em Inglês | MEDLINE | ID: mdl-2189207

RESUMO

A reference system for cholesterol measurement is necessary to assure accuracy of cholesterol measurements by clinical, research, and manufacturers' laboratories. Such a reference system is based on the collaboration of laboratory and clinical professionals, research groups, professional societies, government groups, and manufacturers of diagnostic products. Essential components include a definitive method, a reference method, and commutable reference materials that are accurately labeled and have long-term stability. A mechanism by which clinical, research, and manufacturers' laboratories can establish traceability to the reference system is also needed. In the United States, the NRS/CHOL was organized as part of the National Reference System for the Clinical Laboratory. The major organizational components of the NRS/CHOL include the National Institute for Standards and Technology, the CDC, the CRMN, the CAP, the AAB, regional reference programs, and manufacturers of cholesterol diagnostic products. The NIST maintains an isotope dilution-mass spectrometer definitive method and distributes certified reference materials. The CDC maintains a modified Abell-Levy-Brodie-Kendall reference method and offers a CDC-NHLBI Lipid Standardization Program; the CRMN provides reference method analyses on specimens furnished by manufacturers and clinical or research laboratories; CAP, AAB, and regional reference programs provide either proficiency testing, quality assurance programs, or both; and manufacturers assure that results on diagnostic products are the same as those achieved when using fresh patient specimens and the NRS/CHOL reference method. The NRS/CHOL has contributed much to the success of clinical epidemiologic and research and development investigations in coronary heart disease.


Assuntos
Química Clínica/métodos , Colesterol/sangue , Controle de Qualidade , Química Clínica/normas , Humanos , Cooperação Internacional
15.
J Med Assoc Ga ; 80(5): 301-3, 1991 May.
Artigo em Inglês | MEDLINE | ID: mdl-2072058

RESUMO

Lipid investigators have begun to examine the biological sources of variation in serum cholesterol levels and to seek ways to accurately measure the total cholesterol (TC) level in the serum of a patient. A person's TC level varies primarily because of the effects from seasonal changes, behavioral changes, and illness. Results of studies of the effect of seasonal changes indicate that serum TC and obesity increase during winter and decrease during summer. Behavioral sources of variation include diet, alcohol intake, smoking, and exercise. Clinical sources of TC level variation include all illnesses. The physician can help control sources of variation by recognizing their causes, by advising of the effect that behavioral risk factors have on cholesterol levels, and by using the average of results for multiple specimens to estimate the true value of serum cholesterol in a patient.


Assuntos
Colesterol/sangue , Comportamento , Colesterol na Dieta/administração & dosagem , Doença das Coronárias/prevenção & controle , Humanos , Fatores de Risco , Estações do Ano
20.
J Med Assoc Ga ; 80(2): 81-4, 1991 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-2007833
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