Detalhe da pesquisa
1.
Lactate dehydrogenase inhibition synergizes with IL-21 to promote CD8+ T cell stemness and antitumor immunity.
Proc Natl Acad Sci U S A
; 117(11): 6047-6055, 2020 03 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-32123114
2.
Gambogic acid identifies an isoform-specific druggable pocket in the middle domain of Hsp90ß.
Proc Natl Acad Sci U S A
; 113(33): E4801-9, 2016 08 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-27466407
3.
Lack of mitochondrial topoisomerase I (TOP1mt) impairs liver regeneration.
Proc Natl Acad Sci U S A
; 112(36): 11282-7, 2015 Sep 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-26305952
4.
Synthesis of a stable and orally bioavailable englerin analogue.
Bioorg Med Chem Lett
; 26(11): 2641-4, 2016 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27107948
5.
Molecular chaperone TRAP1 regulates a metabolic switch between mitochondrial respiration and aerobic glycolysis.
Proc Natl Acad Sci U S A
; 110(17): E1604-12, 2013 Apr 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-23564345
6.
Solution formulation development and efficacy of MJC13 in a preclinical model of castration-resistant prostate cancer.
Pharm Dev Technol
; 21(1): 121-6, 2016.
Artigo
em Inglês
| MEDLINE | ID: mdl-25380396
7.
Computational polypharmacology analysis of the heat shock protein 90 interactome.
J Chem Inf Model
; 55(3): 676-86, 2015 Mar 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-25686391
8.
Heat shock protein 90α (HSP90α), a substrate and chaperone of DNA-PK necessary for the apoptotic response.
Proc Natl Acad Sci U S A
; 109(32): 12866-72, 2012 Aug 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-22753480
9.
Charged linker sequence modulates eukaryotic heat shock protein 90 (Hsp90) chaperone activity.
Proc Natl Acad Sci U S A
; 109(8): 2937-42, 2012 Feb 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-22315411
10.
Targeting the regulation of androgen receptor signaling by the heat shock protein 90 cochaperone FKBP52 in prostate cancer cells.
Proc Natl Acad Sci U S A
; 108(29): 11878-83, 2011 Jul 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-21730179
11.
Genome-Wide Analysis Identifies Nuclear Factor 1C as a Novel Transcription Factor and Potential Therapeutic Target in SCLC.
J Thorac Oncol
; 2024 Apr 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-38583771
12.
Mitoribosome sensitivity to HSP70 inhibition uncovers metabolic liabilities of castration-resistant prostate cancer.
PNAS Nexus
; 2(4): pgad115, 2023 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-37091547
13.
Mitochondrial-Encoded Complex I Impairment Induces a Targetable Dependency on Aerobic Fermentation in Hürthle Cell Carcinoma of the Thyroid.
Cancer Discov
; 13(8): 1884-1903, 2023 08 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-37262072
14.
Inhibition of NAD+-Dependent Metabolic Processes Induces Cellular Necrosis and Tumor Regression in Rhabdomyosarcoma Models.
Clin Cancer Res
; 29(21): 4479-4491, 2023 11 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-37616468
15.
Amplification and high-level expression of heat shock protein 90 marks aggressive phenotypes of human epidermal growth factor receptor 2 negative breast cancer.
Breast Cancer Res
; 14(2): R62, 2012 Apr 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-22510516
16.
HSP90-Specific nIR Probe Identifies Aggressive Prostate Cancers: Translation from Preclinical Models to a Human Phase I Study.
Mol Cancer Ther
; 21(1): 217-226, 2022 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34675120
17.
A systematic protocol for the characterization of Hsp90 modulators.
Bioorg Med Chem
; 19(1): 684-92, 2011 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21129982
18.
NMR Methods for Determining Lipid Turnover via Stable Isotope Resolved Metabolomics.
Metabolites
; 11(4)2021 Mar 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-33805301
19.
Inhibitor Combinations Reveal Wiring of the Proteostasis Network in Prostate Cancer Cells.
J Med Chem
; 64(19): 14809-14821, 2021 10 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-34606726
20.
Hsp90 Inhibitor STA9090 Sensitizes Hepatocellular Carcinoma to Hyperthermia-Induced DNA Damage by Suppressing DNA-PKcs Protein Stability and mRNA Transcription.
Mol Cancer Ther
; 20(10): 1880-1892, 2021 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-34376581