Detalhe da pesquisa
1.
Lactate dehydrogenase inhibition synergizes with IL-21 to promote CD8+ T cell stemness and antitumor immunity.
Proc Natl Acad Sci U S A
; 117(11): 6047-6055, 2020 03 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-32123114
2.
Solution formulation development and efficacy of MJC13 in a preclinical model of castration-resistant prostate cancer.
Pharm Dev Technol
; 21(1): 121-6, 2016.
Artigo
em Inglês
| MEDLINE | ID: mdl-25380396
3.
Computational polypharmacology analysis of the heat shock protein 90 interactome.
J Chem Inf Model
; 55(3): 676-86, 2015 Mar 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-25686391
4.
Charged linker sequence modulates eukaryotic heat shock protein 90 (Hsp90) chaperone activity.
Proc Natl Acad Sci U S A
; 109(8): 2937-42, 2012 Feb 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-22315411
5.
Targeting the regulation of androgen receptor signaling by the heat shock protein 90 cochaperone FKBP52 in prostate cancer cells.
Proc Natl Acad Sci U S A
; 108(29): 11878-83, 2011 Jul 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-21730179
6.
Genome-Wide Analysis Identifies Nuclear Factor 1C as a Novel Transcription Factor and Potential Therapeutic Target in SCLC.
J Thorac Oncol
; 2024 Apr 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-38583771
7.
Mitoribosome sensitivity to HSP70 inhibition uncovers metabolic liabilities of castration-resistant prostate cancer.
PNAS Nexus
; 2(4): pgad115, 2023 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-37091547
8.
Mitochondrial-Encoded Complex I Impairment Induces a Targetable Dependency on Aerobic Fermentation in Hürthle Cell Carcinoma of the Thyroid.
Cancer Discov
; 13(8): 1884-1903, 2023 08 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-37262072
9.
Inhibition of NAD+-Dependent Metabolic Processes Induces Cellular Necrosis and Tumor Regression in Rhabdomyosarcoma Models.
Clin Cancer Res
; 29(21): 4479-4491, 2023 11 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-37616468
10.
Amplification and high-level expression of heat shock protein 90 marks aggressive phenotypes of human epidermal growth factor receptor 2 negative breast cancer.
Breast Cancer Res
; 14(2): R62, 2012 Apr 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-22510516
11.
HSP90-Specific nIR Probe Identifies Aggressive Prostate Cancers: Translation from Preclinical Models to a Human Phase I Study.
Mol Cancer Ther
; 21(1): 217-226, 2022 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34675120
12.
NMR Methods for Determining Lipid Turnover via Stable Isotope Resolved Metabolomics.
Metabolites
; 11(4)2021 Mar 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-33805301
13.
The Development of Hsp90ß-Selective Inhibitors to Overcome Detriments Associated with pan-Hsp90 Inhibition.
J Med Chem
; 64(3): 1545-1557, 2021 02 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-33428418
14.
Hsp90 Inhibitor STA9090 Sensitizes Hepatocellular Carcinoma to Hyperthermia-Induced DNA Damage by Suppressing DNA-PKcs Protein Stability and mRNA Transcription.
Mol Cancer Ther
; 20(10): 1880-1892, 2021 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-34376581
15.
Heat shock protein 90 promotes RNA helicase DDX5 accumulation and exacerbates hepatocellular carcinoma by inhibiting autophagy.
Cancer Biol Med
; 2021 Mar 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-33764710
16.
Pharmacologic dissection of the overlapping impact of heat shock protein family members on platelet function.
J Thromb Haemost
; 18(5): 1197-1209, 2020 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-32022992
17.
Dynamic Imaging of LDH Inhibition in Tumors Reveals Rapid In Vivo Metabolic Rewiring and Vulnerability to Combination Therapy.
Cell Rep
; 30(6): 1798-1810.e4, 2020 02 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-32049011
18.
Targeting Glycolysis through Inhibition of Lactate Dehydrogenase Impairs Tumor Growth in Preclinical Models of Ewing Sarcoma.
Cancer Res
; 79(19): 5060-5073, 2019 10 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31431459
19.
Second international symposium on the chaperone code, 2023.
Cell Stress Chaperones
; 29(1): 88-96, 2024 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-38316354
20.
Targeting the Hsp40/Hsp70 Chaperone Axis as a Novel Strategy to Treat Castration-Resistant Prostate Cancer.
Cancer Res
; 78(14): 4022-4035, 2018 07 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-29764864