Detalhe da pesquisa
1.
E. coli and the etiology of human PBC: Antimitochondrial antibodies and spreading determinants.
Hepatology
; 75(2): 266-279, 2022 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-34608663
2.
Probing the E1o-E2o and E1a-E2o Interactions in Binary Subcomplexes of the Human 2-Oxoglutarate Dehydrogenase and 2-Oxoadipate Dehydrogenase Complexes by Chemical Cross-Linking Mass Spectrometry and Molecular Dynamics Simulation.
Int J Mol Sci
; 24(5)2023 Feb 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-36901986
3.
DHTKD1 and OGDH display substrate overlap in cultured cells and form a hybrid 2-oxo acid dehydrogenase complex in vivo.
Hum Mol Genet
; 29(7): 1168-1179, 2020 05 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-32160276
4.
Functional Versatility of the Human 2-Oxoadipate Dehydrogenase in the L-Lysine Degradation Pathway toward Its Non-Cognate Substrate 2-Oxopimelic Acid.
Int J Mol Sci
; 23(15)2022 Jul 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-35897808
5.
Structure-function analyses of the G729R 2-oxoadipate dehydrogenase genetic variant associated with a disorder of l-lysine metabolism.
J Biol Chem
; 295(23): 8078-8095, 2020 06 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-32303640
6.
Conformational dynamics of 1-deoxy-d-xylulose 5-phosphate synthase on ligand binding revealed by H/D exchange MS.
Proc Natl Acad Sci U S A
; 114(35): 9355-9360, 2017 08 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-28808005
7.
Pyruvate dehydrogenase complex deficiency is linked to regulatory loop disorder in the αV138M variant of human pyruvate dehydrogenase.
J Biol Chem
; 293(34): 13204-13213, 2018 08 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-29970614
8.
Oxidative decarboxylation of pyruvate by 1-deoxy-d-xyulose 5-phosphate synthase, a central metabolic enzyme in bacteria.
J Biol Chem
; 293(28): 10857-10869, 2018 07 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-29784878
9.
A multipronged approach unravels unprecedented protein-protein interactions in the human 2-oxoglutarate dehydrogenase multienzyme complex.
J Biol Chem
; 293(50): 19213-19227, 2018 12 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-30323066
10.
Human 2-Oxoglutarate Dehydrogenase and 2-Oxoadipate Dehydrogenase Both Generate Superoxide/H2O2 in a Side Reaction and Each Could Contribute to Oxidative Stress in Mitochondria.
Neurochem Res
; 44(10): 2325-2335, 2019 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-30847859
11.
Evidence for functional and regulatory cross-talk between the tricarboxylic acid cycle 2-oxoglutarate dehydrogenase complex and 2-oxoadipate dehydrogenase on the l-lysine, l-hydroxylysine and l-tryptophan degradation pathways from studies in vitro.
Biochim Biophys Acta Bioenerg
; 1859(9): 932-939, 2018 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-29752936
12.
Competence of Thiamin Diphosphate-Dependent Enzymes with 2'-Methoxythiamin Diphosphate Derived from Bacimethrin, a Naturally Occurring Thiamin Anti-vitamin.
Biochemistry
; 55(7): 1135-48, 2016 Feb 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-26813608
13.
Elucidation of the interaction loci of the human pyruvate dehydrogenase complex E2·E3BP core with pyruvate dehydrogenase kinase 1 and kinase 2 by H/D exchange mass spectrometry and nuclear magnetic resonance.
Biochemistry
; 54(1): 69-82, 2015 Jan 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-25436986
14.
The pyruvate dehydrogenase complexes: structure-based function and regulation.
J Biol Chem
; 289(24): 16615-23, 2014 Jun 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-24798336
15.
Human 2-oxoglutarate dehydrogenase complex E1 component forms a thiamin-derived radical by aerobic oxidation of the enamine intermediate.
J Biol Chem
; 289(43): 29859-73, 2014 Oct 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-25210035
16.
Novel binding motif and new flexibility revealed by structural analyses of a pyruvate dehydrogenase-dihydrolipoyl acetyltransferase subcomplex from the Escherichia coli pyruvate dehydrogenase multienzyme complex.
J Biol Chem
; 289(43): 30161-76, 2014 Oct 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-25210042
17.
Structure and function of the catalytic domain of the dihydrolipoyl acetyltransferase component in Escherichia coli pyruvate dehydrogenase complex.
J Biol Chem
; 289(22): 15215-30, 2014 May 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-24742683
18.
Identification of charge transfer transitions related to thiamin-bound intermediates on enzymes provides a plethora of signatures useful in mechanistic studies.
Biochemistry
; 53(13): 2145-52, 2014 Apr 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-24628377
19.
Insight to the interaction of the dihydrolipoamide acetyltransferase (E2) core with the peripheral components in the Escherichia coli pyruvate dehydrogenase complex via multifaceted structural approaches.
J Biol Chem
; 288(21): 15402-17, 2013 May 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-23580650
20.
Progress in the experimental observation of thiamin diphosphate-bound intermediates on enzymes and mechanistic information derived from these observations.
Bioorg Chem
; 57: 251-262, 2014 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-25228115