RESUMO
Laughing gas (Nitrogen monoxide) is currently abused due to its low price and easy availability. This article discussed the clinical manifestations of a patient with subacute combined degeneration of the spinal cord caused by inhalation of laughing gas. The patient developed numbness of extremities, unstable walking, and decreased serum vitamin B(12) level. MRI of the cervical spine showed abnormal signals in the lateral and posterior cords of the cervical spinal cord (C2-6) , neuroelectrophysiological examination showed peripheral nerve damage in the extremities. After treatment with vitamin B(12) supplementation, the patient's condition gradually improved. Clinicians diagnose subacute combined degeneration of the spinal cord, especially when the patient has no gastrointestinal disease, diet, malnutrition, etc., they need to carefully inquire about the history of nitrous oxide inhalation to avoid missed diagnosis.
Assuntos
Óxido Nitroso , Degeneração Combinada Subaguda , Vértebras Cervicais , Humanos , Imageamento por Ressonância Magnética , Óxido Nitroso/efeitos adversos , Medula Espinal , Degeneração Combinada Subaguda/induzido quimicamente , Vitamina B 12RESUMO
In treated cohorts, individuals with bipolar disorder are more likely to report childhood adversities and recent stressors than individuals without bipolar disorder; similarly, in registry-based studies, childhood adversities are more common among individuals who later become hospitalized for bipolar disorder. Because these types of studies rely on treatment-seeking samples or hospital diagnoses, they leave unresolved the question of whether or not social experiences are involved in the etiology of bipolar disorder. We investigated the role of childhood adversities and adulthood stressors in liability for bipolar disorder using data from the National Epidemiologic Survey on Alcohol and Related Conditions (n=33 375). We analyzed risk for initial-onset and recurrent DSM-IV (Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition) manic episodes during the study's 3-year follow-up period. Childhood physical abuse and sexual maltreatment were associated with significantly higher risks of both first-onset mania (odds ratio (OR) for abuse: 2.23; 95% confidence interval (CI)=1.71, 2.91; OR for maltreatment: 2.10; CI=1.55, 2.83) and recurrent mania (OR for abuse: 1.55; CI=1.00, 2.40; OR for maltreatment: 1.60; CI=1.00, 2.55). In addition, past-year stressors in the domains of interpersonal instability and financial hardship were associated with a significantly higher risk of incident and recurrent mania. Exposure to childhood adversity potentiated the effects of recent stressors on adult mania. Our findings demonstrate a role of social experiences in the initial onset of bipolar disorder, as well as in its prospective course, and are consistent with etiologic models of bipolar disorder that implicate deficits in developmentally established stress-response pathways.
Assuntos
Transtorno Bipolar/epidemiologia , Transtorno Bipolar/etiologia , Maus-Tratos Infantis , Meio Social , Adolescente , Adulto , Transtorno Bipolar/psicologia , Criança , Maus-Tratos Infantis/estatística & dados numéricos , Estudos de Coortes , Manual Diagnóstico e Estatístico de Transtornos Mentais , Feminino , Humanos , Modelos Logísticos , Masculino , Pessoa de Meia-Idade , Recidiva , Adulto JovemRESUMO
Through a national surveillance system for unexplained pneumonia, a severe case of influenza A(H7N9) in a man in his mid-30s was identified in Zhejiang Province, China on 14 October 2013. Epidemiological and clinical findings were consistent with the patterns reported during the outbreak in spring 2013, and laboratory findings showed that the virus had 99.6% identity with earlier H7N9 viruses identified in humans in the spring except for five mutations in the NA gene.
Assuntos
Subtipo H7N9 do Vírus da Influenza A/genética , Subtipo H7N9 do Vírus da Influenza A/isolamento & purificação , Influenza Aviária/diagnóstico , Influenza Humana/diagnóstico , Influenza Humana/virologia , Adulto , Animais , Antivirais/uso terapêutico , Aves , China/epidemiologia , Doenças Transmissíveis Emergentes/epidemiologia , Busca de Comunicante , Surtos de Doenças , Humanos , Influenza Aviária/epidemiologia , Influenza Aviária/virologia , Influenza Humana/tratamento farmacológico , Influenza Humana/epidemiologia , Masculino , Vigilância da População , Aves Domésticas , RNA Viral/genética , Reação em Cadeia da Polimerase em Tempo RealRESUMO
A new bergenin derivative isolated from the root of Ardisia crenata was determined to be 11-o-syringylbergenin by spectral methods. Other compounds were identified as spinasterol, series fatty acids, beta-sitosterol-beta-D-glucoside, norbergenin and sucrose respectively. The last three were obtained for the first time from the genus of Ardisia.
Assuntos
Benzopiranos/isolamento & purificação , Medicamentos de Ervas Chinesas/análise , Fenômenos Químicos , Química , Sitosteroides/isolamento & purificação , Estigmasterol/análogos & derivados , Estigmasterol/isolamento & purificação , Sacarose/isolamento & purificaçãoRESUMO
15 kinds of free amino acids were detected in Rehmannia glutinosa and its processed products, it was found that their contents were reduced in processed products.