Detalhe da pesquisa
1.
Lack of CYP3A4 protein induction despite mRNA induction in primary hepatocytes exposed to rifabutin as a possible explanation for its low interaction risk in vivo.
Arch Toxicol
; 2024 May 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-38713375
2.
Rifabutin but not rifampicin can partly out-balance P-glycoprotein induction by concurrent P-glycoprotein inhibition through high affinity binding to the inhibitory site.
Arch Toxicol
; 98(1): 223-231, 2024 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-37833491
3.
Comprehensive in vitro analysis evaluating the variable drug-drug interaction risk of rifampicin compared to rifabutin.
Arch Toxicol
; 97(8): 2219-2230, 2023 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-37285043
4.
How to avoid misinterpretation of dual reporter gene assay data affected by cell damage.
Arch Toxicol
; 96(9): 2501-2510, 2022 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-35678845
5.
Physiology-based pharmacokinetic modelling and experimental data suggest that rifabutin alters dolutegravir kinetics by both P-glycoprotein induction and concurrent inhibition.
Br J Clin Pharmacol
; 89(7): 2329-2331, 2023 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-37077127
6.
The differences in drug disposition gene induction by rifampicin and rifabutin are unlikely due to different effects on important pregnane X receptor (NR1I2) splice variants.
Naunyn Schmiedebergs Arch Pharmacol
; 397(4): 2485-2496, 2024 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-37851058
7.
Crystal violet staining is a reliable alternative to bicinchoninic acid assay-based normalization.
Biotechniques
; 73(3): 131-135, 2022 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-36000337
8.
Regulation of PXR Function by Coactivator and Corepressor Proteins: Ligand Binding Is Just the Beginning.
Cells
; 10(11)2021 11 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-34831358