Detalhe da pesquisa
1.
The Nutrient and Energy Sensor Sirt1 Regulates the Hypothalamic-Pituitary-Adrenal (HPA) Axis by Altering the Production of the Prohormone Convertase 2 (PC2) Essential in the Maturation of Corticotropin-releasing Hormone (CRH) from Its Prohormone in Male Rats.
J Biol Chem
; 291(11): 5844-5859, 2016 Mar 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-26755731
2.
Obesity induces hypothalamic endoplasmic reticulum stress and impairs proopiomelanocortin (POMC) post-translational processing.
J Biol Chem
; 288(24): 17675-88, 2013 Jun 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-23640886
3.
Temporal changes in nutritional state affect hypothalamic POMC peptide levels independently of leptin in adult male mice.
Am J Physiol Endocrinol Metab
; 306(8): E904-15, 2014 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24518677
4.
Mechanisms by which the orexigen NPY regulates anorexigenic α-MSH and TRH.
Am J Physiol Endocrinol Metab
; 304(6): E640-50, 2013 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23321476
5.
Diet-induced obesity causes severe but reversible leptin resistance in arcuate melanocortin neurons.
Cell Metab
; 5(3): 181-94, 2007 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-17339026
6.
Deficiency of PTP1B in POMC neurons leads to alterations in energy balance and homeostatic response to cold exposure.
Am J Physiol Endocrinol Metab
; 300(6): E1002-11, 2011 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-21406615
7.
Regulation of the hypothalamic thyrotropin releasing hormone (TRH) neuron by neuronal and peripheral inputs.
Front Neuroendocrinol
; 31(2): 134-56, 2010 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-20074584
8.
Maintenance of the thyroid axis during diet-induced obesity in rodents is controlled at the central level.
Am J Physiol Endocrinol Metab
; 299(6): E976-89, 2010 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-20858755
9.
Interactions of peptide amidation and copper: novel biomarkers and mechanisms of neural dysfunction.
Neurobiol Dis
; 37(1): 130-40, 2010 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-19815072
10.
Striatal Nurr1, but not FosB expression links a levodopa-induced dyskinesia phenotype to genotype in Fisher 344 vs. Lewis hemiparkinsonian rats.
Exp Neurol
; 330: 113327, 2020 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-32387398
11.
Endoplasmic Reticulum Stress, the Hypothalamus, and Energy Balance.
Trends Endocrinol Metab
; 30(3): 163-176, 2019 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-30691778
12.
The distribution and mechanism of action of ghrelin in the CNS demonstrates a novel hypothalamic circuit regulating energy homeostasis.
Neuron
; 37(4): 649-61, 2003 Feb 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-12597862
13.
Hypothalamic ER-associated degradation regulates POMC maturation, feeding, and age-associated obesity.
J Clin Invest
; 128(3): 1125-1140, 2018 03 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29457782
14.
Preoptic leptin signaling modulates energy balance independent of body temperature regulation.
Elife
; 72018 05 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-29761783
15.
Regulation of prohormone convertases in hypothalamic neurons: implications for prothyrotropin-releasing hormone and proopiomelanocortin.
Endocrinology
; 148(9): 4191-200, 2007 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-17584972
16.
Cold exposure increases the biosynthesis and proteolytic processing of prothyrotropin-releasing hormone in the hypothalamic paraventricular nucleus via beta-adrenoreceptors.
Endocrinology
; 148(10): 4952-64, 2007 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-17584968
17.
Role of the central melanocortin circuitry in adaptive thermogenesis of brown adipose tissue.
Endocrinology
; 148(4): 1550-60, 2007 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-17194736
18.
Regulation of hypothalamic prohormone convertases 1 and 2 and effects on processing of prothyrotropin-releasing hormone.
J Clin Invest
; 114(3): 357-69, 2004 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-15286802
19.
Discovery of new peptides from old prohormones: insights for energy balance and beyond.
Front Biosci
; 12: 3545-53, 2007 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17485320
20.
The biosynthesis and processing of neuropeptides: lessons from prothyrotropin releasing hormone (proTRH).
Front Biosci
; 12: 3554-65, 2007 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17485321