A clinical and microbiological study on the enantiomers of delmopinol.

Objective The clinical part of this study aimed to investigate whether the racemate of delmopinol [(±)-delmopinol] is equivalent to its two enantiomers [(+)-delmopinol and (-)-delmopinol] with respect to efficiency and to determine and compare their pharmacokinetic properties. The purpose of the pre-clinical part was to elucidate possible differences in antimicrobial efficiency. Materials and methods The compounds were tested clinically in a double-blind, randomized, cross-over study comprising three treatment periods of 4 days each. The antimicrobial efficacy of the enantiomers was compared in vitro with respect to planktonic and biofilm bacteria of different species. Results No statistically significant differences in prevention of plaque formation were observed. Except for a somewhat higher systemic exposure in terms of AUC and Cmax indicated for (-)-delmopinol compared to (+)-delmopinol, the pharmacokinetic properties were similar. The most common adverse event was a transient anaesthetic feeling in the mouth. This event was reported with the same frequency for all three test solutions. The enantiomers showed similar antimicrobial effects on planktonic bacteria and their biofilms. Conclusions The enantiomers were found to be equally effective with respect to inhibition of plaque development and only minor differences were observed with respect to their pharmacokinetic properties. No differences could be observed in the adverse events reports. There is, therefore, no reason to use one of the enantiomers of delmopinol instead of the racemate. This was further supported by the antimicrobial tests. It is suggested that the combined action of cationic and neutral delmopinol is important for its effect on biofilms.

Reimbursement systems influence prosthodontic treatment of adult patients.

OBJECTIVE: To evaluate the influence of reimbursement system and organizational structure on oral rehabilitation of adult patients with tooth loss. MATERIALS AND METHODS: Patient data were retrieved from the databases of the Swedish Social Insurance Agency. The data consisted of treatment records of patients aged 19 years and above claiming reimbursement for dental care from July 1, 2007 until June 30, 2009. Before July 1, 2008, a proportionately higher level of subsidy was available for dental care in patients 65 years and above, but thereafter the system was changed, so that the subsidy was the same, regardless of the patient's age. Prosthodontic treatment in patients 65 years and above was compared with that in younger patients before and after the change of the reimbursement system. Prosthodontic treatment carried out in the Public Dental Health Service and the private sector was also analyzed. RESULTS: Data were retrieved for 722,842 adult patients, covering a total of 1,339,915 reimbursed treatment items. After the change of the reimbursement system, there was a decrease in the proportion of items in patients 65 years and above in relation to those under 65. Overall, there was a minimal change in the proportion of treatment items provided by the private sector compared to the public sector following the change of the reimbursement system. CONCLUSIONS: Irrespective of service provider, private or public, financial incentive such as the reimbursement system may influence the provision of prosthodontic treatment, in terms of volume of treatment.

Qualitative studies of patients' perceptions of loss of teeth, the edentulous state and prosthetic rehabilitation: a systematic review with meta-synthesis.

OBJECTIVE: To conduct a systematic review and meta-synthesis of qualitative studies addressing patients' perceptions of loss of teeth, edentulism and oral rehabilitation. BACKGROUND: Qualitative studies can complement quantitative studies by achieving deep understanding of patients' subjective experiences of losing teeth and coping with edentulism. They can also explore the perception that the benefits of prosthetic rehabilitation extend far beyond primary clinical treatment goals of restoration of oral function. MATERIALS AND METHODS: The major data bases were searched extensively for relevant qualitative and quantitative studies, followed by manual searching of the reference lists of included publications. Two authors independently read all abstracts. Relevant papers were retrieved in full-text and included or excluded according to a specially designed protocol. The included articles were then appraised and rated for quality: high, moderate or low. Articles of low quality were excluded. RESULTS: The database search yielded 36 abstracts of qualitative studies; manual search disclosed one further article. All were read in full-text by two independent authors: 28 were excluded. Of the remaining nine, two (assessed as of low quality) were excluded for further analysis. Meta-synthesis, based on seven studies, disclosed two major themes: loss of quality-of-life associated with losing teeth and restored quality-of-life after oral rehabilitation. CONCLUSIONS: In this relatively new field of research, there are few published papers. Nevertheless, the studies to date show that loss of teeth is associated not only with compromised oral function, but also loss of social status and diminished self-esteem. Oral rehabilitation has broad positive implications, restoring quality of life and self-worth.

Porcelain bonding to titanium with two veneering principles and two firing temperatures.

Dental literature, as well as dental laboratories, has described problems with ceramic veneering of titanium, while clinical and in vitro studies have reported good results. The objective of this study was to investigate the effect of firing temperature, thermo cycling, and veneering methods on bond strength between porcelain and titanium. Eighty titanium specimens were prepared with one of two methods: a bonding agent firing or an oxidation firing. During veneering, half of the specimens in each group were fired at 30 degrees C above and half at the manufacturer's recommended temperature. In the bonding agent group and in the oxidation group, half of each firing group was thermocycled. Bond strength was calculated in a three-point bending test. Scanning electron microscopy (SEM) and energy dispersive X-ray spectroscopy (EDS) analyses of the titanium and the porcelain fracture surfaces of one specimen from each subgroup was used in order to study the composition of the interface between titanium and porcelain surfaces after fracture. No significant difference in bond strength was found when firing at a higher temperature compared with firing at the recommended temperature. An oxidation firing before veneering yielded significantly higher bond strength in a three-point bending test than when firing with a bonding agent. SEM and EDS analyses indicated a higher frequency of titanium oxide fractures in the oxidation than in the bonding agent group.The main finding is that firing at 30 degrees C above the recommended temperature does not significantly affect bond strength between titanium and porcelain. SEM and EDS analysis indicate that fractures occur in the titanium oxide layer by oxidation firing and in the interface between titanium oxide layer and veneering material by bonding agent firing.This finding might indicate that three- point bending test is not a relevant method for determining bond strength in this case, since the firing methods might influence the ductility of the samples.

Validation of the Orofacial Esthetic Scale in the general population.

BACKGROUND: The Orofacial Esthetic Scale (OES) is an eight-item instrument to assess how patients perceive their dental and facial esthetics. In this cross-sectional study we investigated dimensionality, reliability, and validity of OES scores in the adult general population in Sweden. METHODS: In a random sample of the adult Swedish population (response rate: 39%, N=1159 subjects, 58% female, mean age (standard deviation): 49.2 (17.4) years), dimensionality of OES was investigated using factor analytic methods to determine how many scores are needed to characterize the construct. Reliability of scores was calculated using Cronbach's alpha. Score validity was determined by correlating the OES summary score with a global indicator of orofacial esthetics (OE). RESULTS: Factor analyses provided support that a single score can sufficiently characterize OE. A Cronbach's alpha of 0.93 indicated excellent reliability. A validity coefficient of r=0.89 (95% confidence interval: 0.87-0.90) indicated that OES summary scores correlated highly with a global OE assessment. CONCLUSIONS: The OES is a promising instrument to measure the construct OE. Factor analyses supported that this construct can be assessed with one score, offering a feasible and acceptable standardized assessment of OE. The present study extends the OES use to the general population, an important target population for assessment of orofacial esthetics.

Contact allergy to gold in patients with oral lichen lesions.

The aetiology of oral lichen lesions is obscure. In this study the frequency of contact allergy to gold in 83 patients with oral lichen lesions was compared with that in two control groups, comprising 319 age- and gender-matched patients with dermatitis selected from files and 83 clinically examined dermatitis patients. All patients were tested epicutaneously with gold sodium thiosulphate. The two control groups tested were under examination for a tentative diagnosis of allergic dermatitis not related to oral problems. The frequency of contact allergy to gold was 28.9% in the patients with oral lichen lesions, 18.2% in patients selected from files, and 22.9% in the clinically examined control patients. The difference in frequency between patients with oral lichen lesions and those taken from files was statistically significant.

Bonding between titanium and dental porcelain: a systematic review.

OBJECTIVES: The aims of this literature review are to provide answers to questions on how to improve bonding between titanium and dental porcelain and how to further implement, in clinical practice, ceramic-veneered titanium as an alternative to conventional metal-ceramic systems. MATERIAL AND METHODS: A literature search of PubMed and also among referenced published scientific papers was performed and 24 fulfilled the search criteria, namely mentions of titanium, ceramics and bond strength. These papers were compiled for comparison and evaluated regarding the bond strength achieved with different methods. RESULTS: The results strongly indicate that there are possibilities to improve both the present materials and methods for titanium-ceramic veneering. CONCLUSIONS: The results indicate that present knowledge is sufficient to conclude that veneering titanium with low-fused porcelain for crowns and fixed partial dentures can be recommended for routine clinical use.

Decision making among Swedish general dental practitioners concerning prosthodontic treatment planning in a shortened dental arch.

The purposes of this study were to describe how dentists evaluated the importance of various patient-related items when planning for a treatment in a shortened dental arch, to analyse common dimensions of the decision-making in comparison to other decision situations, and to identify explanatory factors behind these dimensions. A questionnaire containing different statements regarding the shortened dental arch concept was sent to a random sample of Swedish general dentists (n=189), with a response rate of 54%. The dentists were asked to evaluate items to be considered when planning for a prosthetic treatment in a shortened dental arch. Differences between individuals were great as well as between groups of dentists. Especially delivery system but also place of dental education and attitudinal factors were related to the shortened dental arch decision making process.

Implant periapical lesion. A case series report.

One complication in implant dentistry is the implant periapical lesion-IPL--which is a lesion around the apex of a stable implant diagnosed radiographically as a radioluscency in the bone at the apical part of an implant.The IPL can perform with or without clinical symptoms such as tenderness, swelling, suppuration and fistulation. This report describes 4 cases of IPL which were treated surgically with sectioning and removal of the affected portion of a stable implant and thorough debridement of the granulomatous tissue around it. This treatment was, up to 4 years after treatment, successful in all 4 cases. It can also from this report be concluded that IPL is a rather rare condition and that it can occur at any stage of implant treatment, in these cases from 4 months up to 11 years after implant installation. Finally there is a discussion about the aetiology of IPL and a comparison to findings in other reports on IPL and it is concluded that it is difficult to claim that there is a single cause to IPL. Rather it is evident that the condition might be a sequel of the summation of many possible causes.This summation exceeds the local biological threshold for the individual patient.

Levels of gold in plasma after dental gold inlay insertion.

OBJECTIVE: Several studies have reported increased levels of gold (Au) in the blood of patients with dental gold restorations. This study analyzed gold levels in blood plasma before dental gold inlay insertion, 0-12 months after, and 15 years after. MATERIAL AND METHODS: Plasma samples from 9 patients were taken before and 0-10 months after gold inlay insertion. Fifteen years after gold inlay insertion, further blood samples taken from 8 of these patients were analyzed for gold using inductively coupled plasma mass spectrometry. An oral examination was also carried out before and 15 years after gold inlay insertion. RESULTS: Gold levels in plasma were significantly higher 0-12 months after gold inlay insertion than before treatment (p=0.008). No significant difference in gold plasma levels was found between 0-12 months after and 15 years after insertion (p=0.109), although there was a significant correlation between the number of gold alloy surfaces and the amount of gold in plasma 15 years after insertion (p=0.028). CONCLUSIONS: This study supports a dose-related release of gold into plasma from dental gold restorations, a release that appears to be stable over time.

Questions and answers on titanium-ceramic dental restorative systems: a literature study.

OBJECTIVE: Titanium ceramics has become a topic of interest for prosthetic applications, thanks to the documented biocompatibility of commercially pure titanium. A number of concepts have been presented, including metal frameworks produced by casting or milling and a number of materials and methods for veneering. However, the concept has not reached a clinical breakthrough since failures have been reported from clinical experiences. METHOD AND MATERIALS: A PubMed search on the following key words was performed: titanium ceramics, long-term results. RESULTS: This review illustrates the fact that it is possible to have success with titanium ceramics on crucial criteria: fit and marginal adaptation, bond strength between metal and ceramics, and esthetic outcome. A review of clinical studies indicates a tendency for success rates to increase with time, which must be explained as a normal learning curve for a technical concept. The learning curve also includes development of materials and methods and the fact that there is a certain amount of technique sensitivity involved in the success rate for titanium ceramics. CONCLUSIONS: There is reason to believe that the outstanding clinical properties of titanium will further catalyze the development of titanium ceramics, and recent experiences clearly indicate that titanium ceramics, being a clinical product ready for use in fixed partial dentures, might already today challenge standard metal ceramics.

All-ceramic two- to five-unit implant-supported reconstructions. A randomized, prospective clinical trial.

The purpose of this study was to evaluate the clinical performance of two to five-unit implant-supported all-ceramic reconstructions and to compare the results of two different all-ceramic systems, Denzir (DZ) and In-Ceram Zirconia (InZ). Eighteen patients were treated with a total of 25 two- to five-unit implant-supported reconstructions. Nine patients were given reconstructions of the DZ system and the other nine reconstructions of the InZ system. The reconstructions were cemented with zinc phosphate cement onto preparable titanium abutments and were evaluated after 6 and 12 months. At the 12-month follow-up, all reconstructions were in function; none had fractured. Superficial cohesive (chip-off) fractures were, however, observed in 6 of the 18 patients (8 of 25 reconstructions). Nine units in the DZ group (in 7 of 13 reconstructions) and one in the InZ group (1 of 12 reconstructions) had chip-off fractures. The difference between the two groups regarding frequency of chip-off fractures was statistically significant (P < 0.01). Marginal integrity was rated excellent at 34 abutments (56%) and acceptable at 27 (44%). Results from this 12-month trial suggest that all-ceramic implant-supported fixed partial dentures of two- to five-units may be considered a treatment alternative. When comparing the two ceramic systems under study, however, this study concludes that the DZ system exhibits an unacceptable amount of veneering porcelain fractures and thus cannot be recommended for the type of treatment evaluated in this trial. Further studies and long-term follow-ups must be performed before the materials and technique can be recommended for general use.

Specialisation and specialist education in prosthetic dentistry in Europe.

This presentation reports on the results of a meeting of prosthodontists from selected European countries. The aim of the meeting was to analyse and promote specialisation and specialist education in Prosthetic Dentistry in Europe. Representatives for Europe were selected from the European Prosthodontic Association (EPA) board, the Education and Research Committee of International College of Prosthodontists (ICP), countries with a legally recognised speciality, countries without a recognised speciality but organised training programmes and countries with neither of these situations. Data about specialisation and specialist training in Prosthodontics in Europe was scrutinised and discussed. The programmes for countries with specialist training had relatively similar content, mostly of three years duration. There was strong agreement that a recognised speciality raises the level of care within the discipline for both specialists and non-specialists. In several of the countries where a speciality had been introduced it had been initiated by pressure from public health planning authorities. The conclusions are that from a professional viewpoint an advancement of the speciality over Europe would develop the discipline, improve oral health planning and quality of patient care. A working group for harmonisation was recommended.

Prosthetic Survival and Complication Rate of Single Implant Treatment in the Periodontally Healthy Patient after 16 to 22 Years of Follow-Up.

BACKGROUND: Single implants were introduced in the 1980s, but long-term follow-up is scarce. PURPOSE: The study aims to retrospectively investigate the prosthetic survival and complication rates of single implants in periodontally healthy patients after 16-22 years, and to evaluate the influence of different prosthetic procedures. MATERIALS AND METHODS: Patients with a single implant were recalled for clinical examination. Prosthetic procedures included single-tooth (ST) and CeraOne (CO) abutments supporting a porcelain-fused-to-metal (PFM), all-ceramic (CER), or gold-acrylic (ACR) crown. Prosthetic survival, success, and occurrence of biological, technical, and aesthetic complications were obtained. Procedures were compared by log-rank tests. RESULTS: Fifty patients attended the examination. All implants were functional; however, 15% of abutments and 27% of crowns had been renewed. Replacements (1/4) were related to technical issues whereas the main cause was aesthetics. The abutment cumulative survival rate (CSR) differed significantly between ST-PFM (74%), ST-ACR (0%), and CO reconstructions (97%). The crown CSR was significantly lower for ST-ACR crowns (0%) compared with ST-PFM (68%) and CO (81%). Thirty-nine percent of implants remained complication free throughout the mean 18.5 years. Complications (1/3) required component replacement, and 53% occurred within 5 years after surgery. CONCLUSION: Prosthetic survival rates of single implants are encouraging after 16 to 22 years. However, 66% of the patients encountered at least one complication during follow-up.

Immediately loaded implants supporting fixed prostheses in the edentulous maxilla: a preliminary clinical and radiologic report.

PURPOSE: To evaluate the survival rate of immediately loaded ITI sand-blasted, large-grit, acid-etched (SLA) solid-screw dental implants in the edentulous maxilla after 8 months of loading. MATERIALS AND METHODS: Twenty-eight patients (mean age 63 years) with edentulous maxillae each received 6 implants and 1 implant-supported fixed provisional prosthesis within 24 hours after surgery. After a mean healing time of 15 weeks, the patient received a definitive, screw-retained, implant-supported fixed prosthesis. A total of 168 implants were placed. Clinical parameters were registered after 1 month of loading with the implant-supported fixed prostheses as well as 8 months after implant placement. Radiologic examinations and assessments were made at implant placement and after 8 months. RESULTS: The mean marginal bone level at implant placement was 1.6 mm (range 0 to 5.1; SD 1.1) apical of the reference point (the implant shoulder). The mean marginal bone level at the 8-month follow-up was 3.2 mm (range 0.4 to 5.9; SD 1.1) apical of the reference point. Three implants failed during the healing period. DISCUSSION: The improved results in the present study might be a result of the positive effect of splinting the implants immediately after placement. CONCLUSION: ITI SLA solid-screw implants immediately loaded (ie, loaded within 24 hours of placement) and supporting fixed prostheses had successful survival rates after 8 months. The present results constitute a solid baseline for future follow-up studies.

Use of abutment-teeth vs. dental implants to support all-ceramic fixed partial dentures: an in-vitro study on fracture strength.

The aim of the present in-vitro study was to compare the fracture strength of all-ceramic Fixed Partial Dentures supported by tooth-analogues and periodontal membrane with the same supported by dental implants. As ceramics are highly brittle, they cannot withstand deformations of more than 0.1% without fracturing. Hence, when planning an all-ceramic FPD, it is essential to evaluate abutment support, as the fracture strength of all-ceramic constructions depends on the stability of the support to reduce strain in the beam of the prosthesis. The support provided by implants differs, however, from the support provided by natural teeth as the implants are anchored directly in the bone with no intermediate tissue. One question that arises is whether strain and stress in the prosthesis are lower when the prosthesis is loaded on implants compared to natural teeth and hence if all-ceramic FPDs benefit from implant support. Twenty-four three-unit all-ceramic FPDs-12 supported by two dental implants and 12 by two tooth-analogues serving as end abutments-were made. All FPDs were subjected to preloading in a preloading procedure and subsequently subjected to load until fracture occurred. Load at fracture were registered and comparisons between the two groups were made. The loads at fracture were statistically significant higher in the group supported by implants compared to the group supported by tooth-analogues (p = 0.003). Within the limitations of this in-vitro study, the following conclusions can be drawn: All-ceramic fixed partial dentures can be used in combination with dental implants. The solid support gained from implants might thus be beneficial for the outcome of such treatment due to decreased strain and stress levels in the prosthesis when loaded on implants compared to when loaded on natural teeth. Clinical studies are, however, needed to confirm these findings as there are more factors that influence the final clinical outcome.

On the accuracy of some in vitro models for mechanical studies of maxillary removable partial dentures.

OBJECTIVES: Comparative in vitro/in vivo studies show wide differences in functional strain magnitudes and patterns of functional strain distribution in prosthetic devices. The aim of this study was to evaluate the accuracy of three in vitro models for biomechanical studies of prosthetic devices. METHODS: Strain gages were attached to the test RPDs of six subjects. In vitro maxillary models with simple (model A), intermediate (model B) and advanced (model C) features for the anatomical simulation of supporting structures were manufactured for each subject. The dentures were subjected to two separate series of standardized functional and laboratorial loading tests. The principal maximum strain value (epsilon (1)) obtained for each gage and experiment was used to calculate the intra-experiment variance and inter-experiment variance for the in vivo and in vitro experiments. The integrated strain gage difference value between the in vitro and in vivo data (Sigma(diff)) was calculated for every loading test and compared to the in vivo inter-experiment variance with ANOVA and Scheffés test. RESULTS: The bite forces recorded were similar for each subject and loading position and between the two loading sessions. The inter- and intra-experiment variance was found to be higher for in vivo loadings than for in vitro. Results showed that the (Sigma(diff)) values for model B and model C were significantly different from the in vivo strain inter-experiment variance (p<0.05). SIGNIFICANCE: This study showed that the anatomical simulation of in vitro models is insufficient to allow for accurate mechanical analyses of maxillary RPDs and that only simple verifications of the strain levels in prosthetic appliances can be attained in vitro.

Early functional loading using Brånemark dental implants.

The present review article discusses the one- and two-stage surgical protocol for dental implant placement as well as the critical amount of micromotion at the bone-implant interface to obtain proper osseointegration. The relevant literature supporting the hypothesis that "splinting of individual implants as soon as possible following installation via a rigid fixed device will most likely decrease the micromotion at the bone-implant interface thus facilitating proper bone healing (osseointegration)" is reported. As a consequence of this approach, the treatment period can be significantly reduced. Finally, the importance of an objective evaluation of the bone quality and initial implant stability is highlighted. The information thus obtained via tools already available will facilitate the decision as to whether to load implants immediately, early, or late, and the term "individual functional loading" is coined.

Oral rehabilitation of tooth loss: a systematic review of quantitative studies of OHRQoL.

PURPOSE: This study aimed to review published quantitative studies for evidence regarding the influence of oral rehabilitation following total or partial tooth loss on self-perceived oral health-related quality of life (OHRQoL). MATERIALS AND METHODS: Three databases were searched using specified indexing terms. The reference lists of relevant publications were also searched manually. Quality of evidence was classified according to GRADE guidelines as high, moderate, low, or very low. RESULTS: The search yielded 2,138 titles and abstracts, 2,102 of which were of a quantitative study design. Based on pre-established criteria, the full-text versions of 322 articles were obtained. After data extraction and interpretation, 5 publications of high or moderate study quality remained. The results of these 5 studies showed positive effects of oral rehabilitation on OHRQoL. Two studies showed substantial improvements. CONCLUSIONS: This is a relatively new field of research; there are very few quantitative studies of how patients perceive OHRQoL following tooth loss and subsequent rehabilitation. While this review indicates that treatment has positive effects on quality of life, the scientific basis is insufficient to support general conclusions about the influence of various interventions on the OHRQoL of patients who have experienced total or partial tooth loss. To achieve a more comprehensive analysis, it is recommended that future studies be based on a combination of quantitative and qualitative methods, ie, questionnaires and semi-structured interviews. The follow-up period must also be appropriate for the specific intervention studied.

Treatment of adult patients with edentulous arches: a systematic review.

PURPOSE: This study aimed to evaluate the outcomes of treatment methods used to rehabilitate adult patients with maxillary and/or mandibular edentulism after at least 5 years of follow-up. The risks, adverse effects, and cost effectiveness of these methods were also evaluated. MATERIALS AND METHODS: Three databases as well as the reference lists of included publications were searched using specified indexing terms. Publications that met the inclusion criteria were read and interpreted using pre-established protocols. Quality of evidence was classified according to the GRADE system (high, moderate, low, or very low). RESULTS: The search yielded 2,130 titles and abstracts. Of these, the full-text versions of 488 publications were obtained. After data extraction and interpretation, 10 studies with moderate study quality of evidence and 1 study with low quality of evidence regarding outcomes, risks, and adverse effects remained. Three studies on the economic aspects of treatment were also included (1 with moderate quality and 2 with low quality). Low-quality evidence showed that the survival rate of implant-supported fixed prostheses is 95% after 5 years in patients with maxillary edentulism and 97% after 10 years in patients with mandibular edentulism. The survival rate of implant-supported overdentures is 93% after 5 years (low-quality evidence). In implant-supported fixed prostheses, 70 of every 1,000 implants are at risk of failing in the maxilla after 5 years and 17 of every 1,000 implants in the mandible are at risk after 10 years. Regarding economic aspects, the evidence was insufficient to provide reliable results. CONCLUSIONS: Due to the low quality of evidence found in the included studies, further research with a higher quality of evidence is recommended to better understand the outcomes of treatment for patients with maxillary and/or mandibular edentulism.