Detalhe da pesquisa
1.
Discovery of ASP6918, a KRAS G12C inhibitor: Synthesis and structure-activity relationships of 1-{2,7-diazaspiro[3.5]non-2-yl}prop-2-en-1-one derivatives as covalent inhibitors with good potency and oral activity for the treatment of solid tumors.
Bioorg Med Chem
; 98: 117581, 2024 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-38176113
2.
Characterisation of a novel KRAS G12C inhibitor ASP2453 that shows potent anti-tumour activity in KRAS G12C-mutated preclinical models.
Br J Cancer
; 126(5): 744-753, 2022 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-34795410
3.
Mucin 21 confers resistance to apoptosis in an O-glycosylation-dependent manner.
Cell Death Discov
; 8(1): 194, 2022 Apr 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-35410995