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1.
Clin Oral Investig ; 28(1): 79, 2024 Jan 06.
Artigo em Inglês | MEDLINE | ID: mdl-38183469

RESUMO

OBJECTIVES: Does the angulation of ultrashort implants influence the stability of the peri-implant bone? The present study aimed to evaluate the effectiveness of non-axial ultrashort implants after 2 to 9 years of follow-up in resorbed alveolar ridges. MATERIALS AND METHODS: All partially edentulous patients with ultrashort implants (< 6 mm) used in the posterior region of an atrophic mandible or maxilla, to support partial dentures in conjunction with standard implants, were included in this study. Peri-implant bone loss, success and survival rates, crestal bone levels, crown-to-implant ratio and implant angulation were measured for each implant. Implants were divided into two groups: straight implants with angulation < 17° (control group) and tilted implants with angulation > 17° (test group). Statistical analysis was used to find any significant differences between the two study groups and to investigate significant linear correlations among all the variables (p = 0.05). RESULTS: A total of 42 ultrashort implants with a mean of 4 years of follow-up were included: 20 ultrashort axially loaded implants and 22 tilted implants. Mean crestal bone levels from baseline loading to maximum follow-up did not reveal statistical differences in regard to PBL; mean success and survival rates were 100% in all groups. CONCLUSIONS: PBL, success and survival rates of axial ultrashort implants and tilted ultrashort implants are comparable to those of conventional implants. CLINICAL RELEVANCE: This retrospective study revealed that ultrashort implants, even when placed with an angulation > 17°, can safely be used to support partial fixed prostheses. Further prospective clinical studies with larger samples and prospective design are needed to confirm these findings.


Assuntos
Implantes Dentários , Humanos , Estudos Retrospectivos , Estudos de Casos e Controles , Seguimentos , Processo Alveolar
2.
Clin Oral Investig ; 27(12): 7737-7751, 2023 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-37917356

RESUMO

OBJECTIVES: Up-to-date literature regarding long-term success of implant rehabilitations after microvascular reconstructions with free fibula flap (FFF) is still very scarce. This study aimed to evaluate clinical outcomes, especially related to oral hygiene conditions, of patients rehabilitated with this technique. MATERIALS AND METHODS: A total of 25 patients who underwent maxillofacial reconstructive surgery with FFF were retrospectively evaluated for soft tissues conditions, oral hygiene habits, and implant survival and success, assessed with a mean follow-up of 6 (range 2-15) years after loading. RESULTS: Fourteen patients received full-arch fixed prostheses and 11 removable bar-supported overdentures. At the follow-up evaluation, 52% of prostheses did not allow proper accessibility for oral hygiene. Overall prosthetic survival was 100%, and implant survival and success were respectively 93.6% and 72%. Prevalence of peri-implantitis was 29% at implant level and that at patient level 96%. CONCLUSIONS: Six-year clinical outcomes of this study reveal that poor oral hygiene practices and compliance by patients who underwent maxillofacial reconstruction with FFF are significantly associated with peri-implant disease. CLINICAL RELEVANCE: Findings of the present study underline the need by clinicians for a careful assessment, in reference to a specific implant therapy, of patient's prosthetic accessibility for oral hygiene procedures.


Assuntos
Implantes Dentários , Retalhos de Tecido Biológico , Doenças da Gengiva , Humanos , Estudos Retrospectivos , Implantação Dentária Endóssea/métodos , Seguimentos , Fíbula/cirurgia , Prótese Dentária Fixada por Implante , Resultado do Tratamento
3.
J Craniofac Surg ; 32(3): e317-e321, 2021 May 01.
Artigo em Inglês | MEDLINE | ID: mdl-29944550

RESUMO

BACKGROUND: The chin is the most prominent and median sector of the lower third of the face giving harmony to nose and lips. The authors present the application of piezoelectric scalpel for the correction of different chin deformities. The distinctive characteristics of this device allow us to avoid or reduce the immediate genioplasty complications. METHODS: Fifty-five patients with defective chin have been treated from January 2006 to April 2008. Intraoral chinplasty was performed during the correction of dentofacial dysmorphisms or associated with nasal surgery. The authors used a piezoelectric cutting device to perform different osteotomies and if necessary, interpositional graft was used to stabilize bony segments. RESULTS: Piezosurgery has been associated with a fewer number of postoperative complications, especially as regard intraoperative bleeding, nerve injuries (immediate and late), hematomas and seromas, and asymmetry (immediate and early). The mean time for completing the complete procedure of genioplasty with piezosurgery was almost the same compared with the saw and drill. CONCLUSIONS: Chinplasty represents one of the most common ancillary procedures and may be associated with corrective surgery of dentofacial dysmorphisms. Mental nerve injuries, asymmetries, intraoperative bleeding are the main immediate complications of genioplasty. Distinctive characteristics of ultrasonic piezoelectric osteotomy are selective cut of mineralized structure with less risk of vascular and nervous damage (microvibrations), intraoperative precision (thin cutting scalpel and no macrovibrations), blood free site (cavitation effect). In our experience, piezoelectric scalpel, compared with saw and drill, enables us to reduce or avoid immediate complications of chin surgery, helping the surgeon to reach patients' satisfaction. LEVEL OF EVIDENCE: IV.


Assuntos
Mentoplastia , Piezocirurgia , Queixo/cirurgia , Humanos , Osteotomia , Instrumentos Cirúrgicos
4.
J Craniofac Surg ; 32(4): 1445-1447, 2021 Jun 01.
Artigo em Inglês | MEDLINE | ID: mdl-33229987

RESUMO

ABSTRACT: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has had a significant impact on people's behavior. The aim of this study has been to evaluate how the SARS-CoV-2 pandemic has impacted the incidence and the features of maxillofacial fractures presented at 6 Italian tertiary centers. Clinical records of all the patients diagnosed for facial fractures between February 23 and May 23, 2019 and 2020 were retrospectively reviewed. Any differences in patient number and characteristics and fracture etiology and site between the 2 groups were then statistically analyzed.There has been a 69.1% decrease in the number of incoming patients during the pandemic. The number of foreign patients has decreased significantly (23.3% versus 9.6%, P = 0.011) while the average age has increased (38.6 versus 45.6 years old, P = 0.01). Specific statistical significant differences for accidental falls (31.8% versus 50.1%, P = 0.005) and sports injuries (16.9% versus 1.4%, P < 0.001) were found. Concerning fracture sites, significant differences have been found in relation to nasal (22.5% versus 11.4%, P = 0.009) and frontal sinus (0.9% versus 4.4%, P = 0.037) fractures. In conclusion, SARS-CoV-2 pandemic has significantly changed the epidemiology and the etiology of facial traumas.


Assuntos
COVID-19 , Traumatismos Maxilofaciais , Fraturas Cranianas , Humanos , Traumatismos Maxilofaciais/epidemiologia , Traumatismos Maxilofaciais/etiologia , Pessoa de Meia-Idade , Pandemias , Estudos Retrospectivos , SARS-CoV-2 , Fraturas Cranianas/epidemiologia
5.
Aesthet Surg J ; 41(9): 1068-1076, 2021 08 13.
Artigo em Inglês | MEDLINE | ID: mdl-32593169

RESUMO

BACKGROUND: Aesthetic treatment of the lower face is increasingly in demand, particularly owing to age-related changes in appearance. VYC-25L is a novel hyaluronic acid filler with high G' and high cohesivity, specifically designed for sculpting and contouring of the chin and jaw. OBJECTIVES: The aim of this study was to assess the use of a grid traced onto the chin and jaw for guiding treatment with VYC-25L. METHODS: This was a retrospective, single-center analysis of data from adult patients undergoing treatment of the lower third of the face with VYC-25L. A grid system of horizontal and vertical lines was used to systematize the process of treatment planning and performance. RESULTS: Thirty subjects were enrolled (53.3% female; mean [standard deviation] age, 34.4 [2.8] years). The mean quantity of VYC-25L used was 4.0 [0.8] mL. Based on the 5-point Global Aesthetic Improvement Scale, 29 patients (96.7%) rated their appearance at 20 days posttreatment as "much improved" or "very much improved." The only complications recorded were early transient soft-tissue edema (n = 14; 46.7%) and bruising (n = 6; 20.0%). There were no cases of infection, paresthesia, asymmetry, hematoma, necrosis, or skin discoloration. CONCLUSIONS: Treatment of the chin and jawline with VYC-25L, with injection locations determined by a standardized grid-based approach, appears to be effective and safe with high rates of patient satisfaction. Injection of this filler offers a potentially high-impact approach for patients across a variety of biological and economic circumstances.


Assuntos
Técnicas Cosméticas , Preenchedores Dérmicos , Envelhecimento da Pele , Adulto , Queixo , Técnicas Cosméticas/efeitos adversos , Preenchedores Dérmicos/efeitos adversos , Feminino , Humanos , Ácido Hialurônico/efeitos adversos , Masculino , Satisfação do Paciente , Estudos Retrospectivos , Resultado do Tratamento
6.
Medicina (Kaunas) ; 57(1)2021 Jan 11.
Artigo em Inglês | MEDLINE | ID: mdl-33440889

RESUMO

Background and Objective: Guided bone regeneration allows new bone formation in anatomical sites showing defects preventing implant rehabilitation. Material and Methods: The present case series reported the outcomes of five patients treated with customized titanium meshes manufactured with a digital workflow for achieving bone regeneration at future implant sites. A significant gain in both width and thickness was achieved for all patients. Results: From a radiographic point of view (CBTC), satisfactory results were reached both in horizontal and vertical defects. An average horizontal gain of 3.6 ± 0.8 mm and a vertical gain of 5.2 ± 1.1 mm. Conclusions: The findings from this study suggest that customized titanium meshes represent a valid method to pursue guided bone regeneration in horizontal, vertical or combined defects. Particular attention must be paid by the surgeon in the packaging of the flap according to a correct method called the "poncho" technique in order to reduce the most frequent complication that is the exposure of the mesh even if a partial exposure of one mesh does not compromise the final outcome of both the reconstruction and the healing of the implants.


Assuntos
Aumento do Rebordo Alveolar , Titânio , Regeneração Óssea , Humanos , Próteses e Implantes , Telas Cirúrgicas
7.
J Craniofac Surg ; 31(3): e266-e270, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32097381

RESUMO

The purpose of this study is to present the chimeric scapula tip-free flap as a reconstructive choice in composite head and neck defects and to highlight the experiences of the authors in this field.A retrospective study and a literature review were conducted. Data about preoperative condition, intraoperative images, and radiological and clinical documentation were collected.Excision of head and neck advanced cancers may result in large composite defects containing different types of soft tissue and bone. This topic is particularly challenging in salvage surgery after radiation therapy. In this setting, reconstructive techniques are very complex and traditionally require the use of multiple microvascular flaps. Chimeric free flaps, based on the subscapular system, allow complex reconstructions, providing both soft tissue and bone on a single vascular peduncle.The regional anatomy of the subscapular system and the possible chimeric flaps that can be harvested will be discussed, together with the reconstructive surgical technique used and the positioning of the patient. Two representative clinical cases of complex head and neck reconstruction after radiotherapy are presented.Different types of chimeric flap can be harvested from the subscapular system. These flaps can include different tissues: skin, bone, muscle on a single vascular peduncle. This characteristic is particularly useful in complex defects with different tissue types involved, following large en-bloc excision of advanced head and neck tumors.Free flaps based on the subscapular system can be an excellent reconstructive choice in complex head and neck defects.


Assuntos
Retalhos de Tecido Biológico/cirurgia , Neoplasias de Cabeça e Pescoço/cirurgia , Neoplasias Mandibulares/cirurgia , Procedimentos de Cirurgia Plástica , Idoso , Feminino , Neoplasias de Cabeça e Pescoço/diagnóstico por imagem , Humanos , Masculino , Neoplasias Mandibulares/diagnóstico por imagem , Pessoa de Meia-Idade , Estudos Retrospectivos , Tomografia Computadorizada por Raios X
8.
Undersea Hyperb Med ; 47(4): 571-580, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-33227833

RESUMO

Objectives: To clinically and microbiologically evaluate the effects of hyperbaric oxygen (HBO2) therapy in addition to full-mouth ultrasonic subgingival debridement (FM-UD), in the initial treatment of chronic periodontitis. Methods: Twenty patients presenting moderate to severe generalized forms of chronic periodontitis were included in a three-month randomized, parallel-group, single-blinded, prospective study. At baseline patients were randomly assigned to two treatment groups [Test Group (FM-UD+HBO2) and Control Group (FM-UD)]. Both groups were treated with an FM-UD session. Ten HBO2 sessions (one session per day for 10 days at a pressure of 2.5 ATA) were additionally administered to the Test Group. Soft tissues parameters [probing pocket depth (PPD), bleeding on probing (BOP), clinical attachment level (CAL) and visible plaque index (VPI)] were assessed at baseline (immediately before FM-UD treatment), after two weeks, after six weeks and at three months. For each patient, a site presenting PPD ≥ 6mm and positive BOP was selected as a qualifying site (QS), to be monitored clinically (at T0, T1, T2 and T3) and microbiologically (at T0, T1 and T3). Results: There were no statistically significant differences between the two groups for any clinical parameter analyzed after three months, except for BOP, which was significantly (p < 0.05) reduced in the Test Group. Reductions in bacterial levels were detected in both groups after therapy. Faster bacterial recolonization occurred after three months in the Control Group. Conclusion: HBO2 therapy in combination with FM-UD may represent an efficacious approach to the treatment of moderate to severe forms of periodontitis.


Assuntos
Periodontite Crônica/terapia , Oxigenoterapia Hiperbárica/métodos , Desbridamento Periodontal/métodos , Adulto , Periodontite Crônica/microbiologia , Terapia Combinada/métodos , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Projetos Piloto , Porphyromonas gingivalis/isolamento & purificação , Estudos Prospectivos , Método Simples-Cego , Tannerella forsythia/isolamento & purificação , Treponema denticola/isolamento & purificação , Terapia por Ultrassom/métodos , Adulto Jovem
9.
J Oral Implantol ; 46(4): 396-406, 2020 Aug 01.
Artigo em Inglês | MEDLINE | ID: mdl-32315035

RESUMO

The purpose of this retrospective study was to determine survival and peri-implant marginal bone loss of short and ultra-short implants placed in the posterior mandible. A total of 98 patients received 201 locking-taper implants between January 2014 and January 2015. Implants were placed with a 2-stage approach and restored with single crowns. Clinical and radiographic examinations were performed at 3-year recall appointments. At that time, the proportion of implant survival by length, and variations of crestal bone levels (mean crestal bone loss and mean apical shift of the "first bone-to-implant contact point" position) were assessed. Significance level was set at 0.05. The total number of implants examined 36 months after loading included: 71 implants, 8.0 mm in length; 82 implants, 6.0 mm in length; and 48 implants, 5.0 mm in length. Five implants failed. The overall proportion of survival was 97.51%, with 98.59% for the 8.0-mm implants, 97.56% for the 6.0-mm implants, and 95.83% for the 5.0-mm implants. No statistically significant differences were found among the groups regarding implant survival (P = .73), mean crestal bone loss (P = .31), or mean apical shift of the "first bone-to-implant contact point" position (P = .36). Single-crown short and ultra-short implants may offer predictable outcomes in the atrophic posterior mandibular regions, though further investigations with longer follow-up evaluations are necessary to validate our results.


Assuntos
Perda do Osso Alveolar , Implantes Dentários , Perda do Osso Alveolar/diagnóstico por imagem , Coroas , Planejamento de Prótese Dentária , Prótese Dentária Fixada por Implante , Falha de Restauração Dentária , Seguimentos , Humanos , Mandíbula/diagnóstico por imagem , Mandíbula/cirurgia , Estudos Retrospectivos
10.
Orthod Craniofac Res ; 22(3): 208-212, 2019 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-30908883

RESUMO

OBJECTIVES: To analyse through comet assay and micronucleus test the viability and DNA damage occurred in buccal mucosa epithelial cells after a short-term exposure to Andresen activator resin monomers. SETTING AND SAMPLE POPULATION: Test group consisting of 26 subjects was treated with Andresen activator; 16 subjects who had never undergone orthodontic treatment were enrolled in the control group. MATERIAL & METHODS: Buccal mucosa samples were collected before treatment and after 7, 15, 30, 60 and 90 days. The analyses performed on the cells included the following: cellular viability, comet assay and micronucleus test. Mean ± SD were calculated for cellular viability, tail moment, tail intensity, tail length, micronuclei, binuclear and bud cells. Significance (P < 0.05) was evaluated with Dunnett's test. RESULTS: Cellular viability did not change during observational time, and its trend was similar to the controls. Tail moment and tail intensity significantly increased after 30 and 60 days, respectively, whereas tail length remained unchanged over time in the test group; the same parameters did not change in the control group. In the test group, micronuclei, binuclear and bud cells significantly increased after 30, 60 and 90 days, respectively. CONCLUSION: The resin monomers of the Andresen activator cause genotoxic effects detectable through comet assay and micronucleus test, but they do not produce clear cytotoxic effects after a 90 days exposure.


Assuntos
Dano ao DNA , Mucosa Bucal , Ensaio Cometa , Células Epiteliais , Testes para Micronúcleos
11.
J Oral Maxillofac Surg ; 77(12): 2475-2482, 2019 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-31445033

RESUMO

PURPOSE: To evaluate the role of middle meatal antrostomy in preventing the onset of maxillary sinusitis after placement of zygomatic implants. We hypothesized that middle meatal antrostomy might reduce the incidence of this complication. MATERIALS AND METHODS: A prospective longitudinal study was performed of patients who had undergone placement of 4 zygomatic implants and concurrent middle meatal antrostomy with an endoscopic approach at the maxillofacial surgery unit of Verona University. The radiological results of the maxillary sinuses were evaluated on computed tomography scans performed 12 months after surgery using the Lund-Mackay staging system. Clinical symptoms were evaluated both preoperatively and 12 months after surgery using the Sino-Nasal Outcome Test-20 (SNOT-20). Intraoperative violation of the Schneiderian membrane was also assessed. The outcomes from the present study were compared with historical controls. RESULTS: The sample included 13 patients, 26 maxillary sinuses with negative radiologic findings of sinonasal pathologic features, and 52 zygomatic implants. A moderate increase was found in radiologic findings of sinonasal pathologic features postoperatively compared with preoperatively, with mucosal hypertrophy in 3 maxillary sinuses (11.5%). The incidence and severity of mucosal hypertrophy was significantly lower than the outcomes of the historical controls. The average preoperative SNOT-20 score was 13.45, and the postoperative SNOT-20 score was 1.18. The Schneiderian membrane was pierced in 13 sinuses in 9 patients. CONCLUSIONS: Shrinkage of the ostiomeatal complex seems to play a fundamental role in the onset of sinonasal pathologic features after zygomatic implant placement compared with implant-related causes. Although functional endoscopic sinus surgery is a supplementary surgical method in implant placement, it seems to provide statistically significant improvement in the health of the sinonasal system. Perforation of the Schneiderian membrane does not appear to correlate with the onset of sinus opacification and sinonasal symptoms.


Assuntos
Implantes Dentários , Endoscopia , Sinusite Maxilar , Humanos , Estudos Longitudinais , Seio Maxilar , Sinusite Maxilar/cirurgia , Estudos Prospectivos , Resultado do Tratamento
12.
Lasers Med Sci ; 34(7): 1449-1455, 2019 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-30762198

RESUMO

Minimally invasive facial rejuvenation procedures reached an all-time high in the 2016. This reveals a growing interest in a smoother, younger, and tighter look accessible using the esthetic medicine tools like botulinum toxin and dermal filler injections, laser, and microdermabrasion. Forty-five patients from 35 to 52 years old (medium age 43.8), 38 women and 7 men underwent 5 sessions of Fraxel laser, 1 session of very low G prime HA, and Microbotox injection treatments from January 2016 and January 2017, were included in this study. In this study, we demonstrated that the usage of three treatments together, like mBTX, Volite, and Fractional laser, have a better result despite every single technique alone. The clinical result showed 98% (44 patients, 6 males, 38 females) of the patients had a smoother skin surface, brighter, more hydrated, and elastic skin; 68% of our patients (31 patients, 5 males, 26 females) showed less skin defects and staining as well as less small wrinkles, thanks to Fraxel laser treatment; 98% (44 patients, 6 males, 38 females) showed tighter skin with less sebaceous gland secretion. The aim of this study was to demonstrate that the combination of three techniques acts better and faster than single treatment to contrast facial aging and to improve skin texture and quality.


Assuntos
Técnicas Cosméticas , Ácido Hialurônico/farmacologia , Lasers , Rejuvenescimento , Pele/efeitos dos fármacos , Pele/efeitos da radiação , Adulto , Face/efeitos da radiação , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Envelhecimento da Pele/efeitos dos fármacos
13.
J Craniofac Surg ; 30(4): 1154-1162, 2019 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-30839457

RESUMO

The present paper aims to evaluate the long-term incidence and severity of the neurosensory disturbance (NSD) of the inferior alveolar nerve following bilateral sagittal split osteotomy (BSSO) of the mandibular ramus performed with piezosurgery. A retrospective study on patients referred to the Maxillofacial Surgery and Dentistry Clinic of the University of Verona for orthognathic surgery between March 2013 and October 2015 was performed. Inclusion criteria were having undergone BSSO with piezosurgery and follow-up lasting at least 24 months. Exclusion criteria were history of surgical infection, osteosynthesis failure or re-do surgery. The extent of mandibular repositioning movements was retrieved and patients underwent 4 clinical neurosensory tests. Descriptive statistical analysis was performed. 52 patients met the inclusion criteria. Average follow-up was 40 months (range 24-75). 83% of the nerves examined have no or slightly altered sensitivity. Seventy-one percent of patients perceive a moderate to none discomfort and none describes the discomfort as serious (Visual Analogue Scale [VAS] >7). The extent of mandibular repositioning did not have significant influence on the development and severity of the NSD. Resulting data led the Authors to infer that using piezosurgery in BSSO, the severity of the NSD of inferior alveolar nerve is reduced, but the incidence of permanent nerve lesions remains unchanged, compared to historical controls.


Assuntos
Osteotomia Sagital do Ramo Mandibular , Piezocirurgia , Complicações Pós-Operatórias , Traumatismos do Nervo Trigêmeo , Humanos , Osteotomia Sagital do Ramo Mandibular/efeitos adversos , Osteotomia Sagital do Ramo Mandibular/métodos , Osteotomia Sagital do Ramo Mandibular/estatística & dados numéricos , Piezocirurgia/efeitos adversos , Piezocirurgia/estatística & dados numéricos , Complicações Pós-Operatórias/epidemiologia , Complicações Pós-Operatórias/fisiopatologia , Estudos Retrospectivos , Traumatismos do Nervo Trigêmeo/epidemiologia , Traumatismos do Nervo Trigêmeo/fisiopatologia
14.
Int J Mol Sci ; 20(2)2019 Jan 11.
Artigo em Inglês | MEDLINE | ID: mdl-30641957

RESUMO

BACKGROUND: The aims of this narrative review were to examine up-to-date literature in order to evaluate the effectiveness of arthrocentesis or injections with platelet-rich plasma in temporomandibular affections and to compare them to arthrocentesis alone or with hyaluronic acid (HA) or to hyaluronic acid injections. METHODS: The search of international literature was made on the PMC, PubMed and Cochrane databases, including all full-length text of studies on humans focused on osteoarthritis and disc displacements and their treatment with platelet-rich plasma arthrocentesis or injections. All design studies were included in the review and they were examined for three different outcomes: pain, joint sound and mandibular motion. English papers were only selected. RESULTS: Even though the low number of studies in this field, arthrocentesis with platelet-rich plasma and platelet-rich plasma injections in temporomandibular disorders' management were found to be effective in reducing pain and joint sound as well as in improving mandibular motion in a maximum follow-up of 24 months. CONCLUSION: Comparison to arthrocentesis alone or to HA use in arthrocentesis or by injections provided encouraging results in terms of the effectiveness of platelet-rich plasma use.


Assuntos
Artrocentese/métodos , Plasma Rico em Plaquetas/fisiologia , Síndrome da Disfunção da Articulação Temporomandibular/terapia , Humanos , Ácido Hialurônico/administração & dosagem , Ácido Hialurônico/fisiologia , Injeções , Medição da Dor , Amplitude de Movimento Articular/efeitos dos fármacos , Síndrome da Disfunção da Articulação Temporomandibular/fisiopatologia , Resultado do Tratamento
15.
Eur J Vasc Endovasc Surg ; 56(1): 7-14, 2018 07.
Artigo em Inglês | MEDLINE | ID: mdl-29784555

RESUMO

BACKGROUND: The aim of this pilot study was to identify multidetector computed tomography angiography (MDCTA) features that may help identify carotid atherosclerotic plaques (CAPs) with severe histological heterogeneity. METHODS: Thirty-one CAPs (9 symptomatic) were evaluated histologically using a semiquantitative scale. The CAPs were assessed for the presence of ulceration, lipids, fibrosis, thrombotic deposits, haemorrhage, neovascularisation, and inflammation. A CAP presenting at least five of these histological features was defined as a severe heterogeneous plaque (Group A); in all other cases it was defined as a mild to moderate heterogeneous plaque (Group B). The non-calcified plaque tissue was segmented in pre-operative MDCTA. Median and mean intensity and percentages of soft tissue voxels with a value smaller than or equal to certain thresholds (from 20 HU to 200 HU with a constant distance of 20 HU) were calculated. Comparison of intensity measurements was analysed by Mann-Whitney U test and receiver operating characteristic (ROC) analysis. In order to assess the method reliability, values showing better performance were compared using the Wilcoxon signed rank test and k-Cohen test according to ROC analysis. RESULTS: According to histological analysis 18 CAPs were classified as belonging to Group B and 13 to Group A. The percentages of soft tissue with density ≤ 40 (TH_40), 60 (TH_60), 80 (TH_80), and 100 HU (TH_100) were statistically significantly greater in plaques of Group A (respectively p = .016, p = .002, p = .001, p = .007). The mean (p = .025) and median (p = .014) intensity were statistically significantly lower in the plaques of Group A. TH_60 and TH_80 showed the greatest accuracy (0.81) with similar performance in term of AUC and sensitivity/specificity (TH_60: 0.82, 0.62, 0.94; TH_80: 0.83, 0.69, 0.89, respectively, for AUC, sensitivity and specificity). Reliability analysis showed good repeatability and reproducibility of these measurements. CONCLUSIONS: The findings have demonstrated lower density of the non-calcified tissue in the plaques of Group A with higher TH_60 and TH_80 soft tissue percentages with respect to CAPs of Group B.


Assuntos
Artérias Carótidas/diagnóstico por imagem , Artérias Carótidas/patologia , Estenose das Carótidas/diagnóstico por imagem , Estenose das Carótidas/patologia , Angiografia por Tomografia Computadorizada , Tomografia Computadorizada Multidetectores , Placa Aterosclerótica , Idoso , Idoso de 80 Anos ou mais , Área Sob a Curva , Doenças Assintomáticas , Biópsia , Estenose das Carótidas/complicações , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Variações Dependentes do Observador , Projetos Piloto , Valor Preditivo dos Testes , Curva ROC , Interpretação de Imagem Radiográfica Assistida por Computador , Reprodutibilidade dos Testes , Medição de Risco , Fatores de Risco , Índice de Gravidade de Doença , Software , Acidente Vascular Cerebral/etiologia
16.
J Craniofac Surg ; 29(8): 2156-2159, 2018 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-30277941

RESUMO

BACKGROUND: The chin is the most prominent and median sector of the lower third of the face giving harmony to nose and lips. The authors present the application of piezoelectric scalpel for the correction of different chin deformities. The distinctive characteristics of this device allow the authors to avoid or reduce the immediate genioplasty complications. METHODS: Fifty-five patients of defective chin have been treated from January 2006 to April 2008. Intraoral genioplasty was performed during the correction of dentofacial dysmorphisms or associated with nasal surgery. The authors used a piezoelectric cutting device to perform different osteotomies and if necessary, interpositional graft was used to stabilize bony segments. RESULTS: Piezosurgery has been associated with a fewer number of postoperative complications, especially as regard intraoperative bleeding, nerve injuries (immediate and late), hematomas and seromas, asymmetry (immediate and early). The mean time for completing the complete procedure of genioplasty with piezosurgery was almost the same compared with the saw and drill. CONCLUSION: Genioplasty represents one of the most common ancillary procedures and may be associated with corrective surgery of dentofacial dysmorphisms. Mental nerve injuries, asymmetries, intraoperative bleeding are the main immediate complications of genioplasty. Distinctive characteristics of ultrasonic piezoelectric osteotomy are selective cut of mineralized structure with less risk of vascular and nervous damage (microvibrations), intraoperative precision (thin cutting scalpel and no macrovibrations), blood free site (cavitation effect). In the authors' experience, piezoelectric scalpel, compared with saw and drill, enables them to reduce or avoid immediate complications of chin surgery, helping the surgeon to reach patients' satisfaction.


Assuntos
Mentoplastia/métodos , Osteotomia/métodos , Piezocirurgia/instrumentação , Procedimentos de Cirurgia Plástica/métodos , Complicações Pós-Operatórias/epidemiologia , Adolescente , Adulto , Queixo/cirurgia , Feminino , Mentoplastia/efeitos adversos , Humanos , Masculino , Osteotomia/efeitos adversos , Satisfação do Paciente , Piezocirurgia/efeitos adversos , Procedimentos de Cirurgia Plástica/efeitos adversos , Estudos Retrospectivos , Instrumentos Cirúrgicos , Adulto Jovem
17.
J Cell Physiol ; 232(1): 176-81, 2017 01.
Artigo em Inglês | MEDLINE | ID: mdl-27064510

RESUMO

Simian Virus 40 (SV40), a monkey polyomavirus, was administered to human populations by early anti-poliomylitis vaccines contaminated by this small DNA tumor virus. Data on SV40 infection in humans remain controversial. Elderly subjects represent an interesting cohort to investigate, because they were not immunized with SV40-contaminated vaccines. Taking advantage of the Italian population, the second oldest worldwide, elderly subjects (n = 237) up to 100 years old were enrolled in this study. Their sera were analyzed, by ELISA tests with synthetic peptides mimicking the viral epitopes, for IgG antibodies reacting with SV40 large Tumor antigen (Tag), the viral oncoprotein. An overall seroprevalence of 22% was revealed in subjects aged 66-100 years, ranging from 19% in individuals 66-74 years old, to 24% in subjects 82-100 years old, with a lower SV40 titer detected in the oldest group. Our data show that: (i) SV40 infection is not frequent in old individuals; (ii) the infection rate increases in elderly with the age; (iii) the antibody titer of SV40 Tag decreases with the age. In conclusion, SV40 infection seems to spread in old subjects independently from SV40-contaminated vaccines. This study seems to confirm that SV40 is also a human virus. J. Cell. Physiol. 232: 176-181, 2017. © 2016 Wiley Periodicals, Inc.


Assuntos
Anticorpos/sangue , Antígenos Virais de Tumores/imunologia , Vírus 40 dos Símios/imunologia , Idoso , Idoso de 80 Anos ou mais , Envelhecimento , Anticorpos/imunologia , Feminino , Voluntários Saudáveis , Humanos , Masculino , Proteínas Oncogênicas/imunologia , Infecções por Polyomavirus/imunologia , Infecções por Polyomavirus/virologia , Estudos Soroepidemiológicos , Infecções Tumorais por Vírus/imunologia , Infecções Tumorais por Vírus/virologia
18.
J Oral Maxillofac Surg ; 75(2): 348-356, 2017 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-27818079

RESUMO

PURPOSE: This study evaluated the outcomes and complications of the surgical treatment of condylar fractures by the retromandibular transparotid approach. The authors hypothesized that such an approach would be safe and reliable for the treatment of most condylar fractures. MATERIALS AND METHODS: A retrospective evaluation of patients who underwent surgical reduction of a condylar fracture from January 2012 to December 2014 at the Clinic of Dentistry and Maxillofacial Surgery of the University Hospital of Verona (Verona, Italy) was performed. Inclusion criteria were having undergone surgical treatment of condylar fractures with a retromandibular transparotid approach and the availability of computed tomograms of the preoperative and postoperative facial skeleton with a minimum follow-up of 1 year. Static and dynamic occlusal function, temporomandibular joint health status, presence of neurologic impairments, and esthetic outcomes were evaluated in all patients. RESULTS: The sample was composed of 25 patients. Preinjury occlusion and temporomandibular joint health were restored in most patients. Esthetic outcomes were deemed satisfactory by clinicians and patients. Neither permanent neurologic impairments nor major postoperative complications were observed. CONCLUSIONS: According to the results of the present study, the retromandibular transparotid approach is a viable and safe approach for the surgical treatment of condylar fractures.


Assuntos
Côndilo Mandibular/lesões , Fraturas Mandibulares/cirurgia , Adolescente , Adulto , Idoso , Feminino , Humanos , Masculino , Côndilo Mandibular/diagnóstico por imagem , Côndilo Mandibular/cirurgia , Fraturas Mandibulares/diagnóstico por imagem , Pessoa de Meia-Idade , Estudos Retrospectivos , Tomografia Computadorizada por Raios X , Adulto Jovem
19.
J Craniofac Surg ; 28(3): 810-812, 2017 May.
Artigo em Inglês | MEDLINE | ID: mdl-28060092

RESUMO

The loss of teeth and the alveolar bone secondary to resection of mandibular tumors may lead to unfavorable esthetic and functional results with a significant impairment of mastication.The authors report a 53-year-old patient with recurrence of ameloblastoma who was submitted to marginal mandibulectomy. Bone defect was immediately reconstructed using fresh frozen bone graft and 9 months after reconstruction 3 dental implants were inserted in the grafted bone. After 6 months, dental rehabilitation was achieved using a fixed implant-supported prosthesis.The purpose of this clinical report was to show the use of fresh frozen bone graft in the recostruction of mandibular nonsegmental defects.The clinical outcome of bone grafts and dental implants is analyzed retrospectively.


Assuntos
Ameloblastoma , Transplante Ósseo/métodos , Mandíbula , Neoplasias Mandibulares , Osteotomia Mandibular , Reconstrução Mandibular , Recidiva Local de Neoplasia , Ameloblastoma/patologia , Ameloblastoma/cirurgia , Implantação Dentária Endóssea/métodos , Implantes Dentários , Estética Dentária , Humanos , Masculino , Mandíbula/diagnóstico por imagem , Mandíbula/patologia , Mandíbula/cirurgia , Neoplasias Mandibulares/patologia , Neoplasias Mandibulares/cirurgia , Osteotomia Mandibular/efeitos adversos , Osteotomia Mandibular/métodos , Reconstrução Mandibular/métodos , Reconstrução Mandibular/reabilitação , Pessoa de Meia-Idade , Recidiva Local de Neoplasia/patologia , Recidiva Local de Neoplasia/cirurgia , Estudos Retrospectivos , Resultado do Tratamento
20.
J Oral Maxillofac Surg ; 74(6): 1238.e1-1238.e15, 2016 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-26954559

RESUMO

PURPOSE: To evaluate the long-term results of cheekbone augmentation using porous hydroxyapatite granules mixed with microfibrillar collagen in a large group of patients. MATERIALS AND METHODS: Four hundred thirty patients who underwent zygomatic augmentation and intermaxillary osteotomy were evaluated clinically, radiologically, and histologically. RESULTS: Complications were found in 13 patients (1.56%). There were no relevant radiologic differences in prosthesis volume after 1 month (T1) or after 24 months (T2) in any patient; there were no clinically relevant differences in 110 patients after 36 months. At T1, the prosthesis had a granular structure and the granules had not migrated; at T2, the prosthesis was staunchly adhering to the underlying bone. Over time, the radiopacity of the material increased. Histologic results of 19 biopsy specimens obtained from 8 patients 2 years after the procedure showed prominent ossification with low inflammation, confirming new bone formation over time. According to the visual analog scale, the patients were generally satisfied with the aspects that were considered. CONCLUSION: Hydroxyapatite and collagen composite used during malarplasty produced a successful outcome. Its main drawback is a learning curve that is longer than for more frequently used implantable biomaterials.


Assuntos
Colágeno/uso terapêutico , Durapatita/uso terapêutico , Zigoma/cirurgia , Adolescente , Adulto , Tomografia Computadorizada de Feixe Cônico , Feminino , Humanos , Masculino , Osteotomia Maxilar/métodos , Implante de Prótese Maxilofacial/métodos , Pessoa de Meia-Idade , Cirurgia Ortognática/métodos , Cirurgia Plástica/métodos , Adulto Jovem , Zigoma/diagnóstico por imagem
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