Detalhe da pesquisa
1.
Bioengineered models of Parkinson's disease using patient-derived dopaminergic neurons exhibit distinct biological profiles in a 3D microenvironment.
Cell Mol Life Sci
; 79(2): 78, 2022 Jan 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-35044538
2.
Efficient introduction of specific homozygous and heterozygous mutations using CRISPR/Cas9.
Nature
; 533(7601): 125-9, 2016 May 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-27120160
3.
Selective linkage of mitochondrial enzymes to intracellular calcium stores differs between human-induced pluripotent stem cells, neural stem cells, and neurons.
J Neurochem
; 156(6): 867-879, 2021 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-32865230
4.
Altered transcriptome and disease-related phenotype emerge only after fibroblasts harvested from patients with age-related macular degeneration are differentiated into retinal pigment epithelium.
Exp Eye Res
; 207: 108576, 2021 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-33895162
5.
High-throughput screening identifies compounds that protect RPE cells from physiological stressors present in AMD.
Exp Eye Res
; 185: 107641, 2019 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-30980814
6.
Nuclear genome transfer in human oocytes eliminates mitochondrial DNA variants.
Nature
; 493(7434): 632-7, 2013 Jan 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-23254936
7.
Automated, high-throughput derivation, characterization and differentiation of induced pluripotent stem cells.
Nat Methods
; 12(9): 885-92, 2015 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-26237226
8.
Intermediate filament protein accumulation in motor neurons derived from giant axonal neuropathy iPSCs rescued by restoration of gigaxonin.
Hum Mol Genet
; 24(5): 1420-31, 2015 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25398950
9.
Human oocytes reprogram somatic cells to a pluripotent state.
Nature
; 478(7367): 70-5, 2011 Oct 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-21979046
10.
Characterization of a subpopulation of developing cortical interneurons from human iPSCs within serum-free embryoid bodies.
Am J Physiol Cell Physiol
; 308(3): C209-19, 2015 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25394470
11.
SMAD7 directly converts human embryonic stem cells to telencephalic fate by a default mechanism.
Stem Cells
; 31(1): 35-47, 2013 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-23034881
12.
Isogenic human trophectoderm cells demonstrate the role of NDUFA4 and associated variants in ZIKV infection.
iScience
; 26(7): 107001, 2023 Jul 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-37534130
13.
Common genetic variation impacts stress response in the brain.
bioRxiv
; 2023 Dec 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-38234801
14.
Modeling gene × environment interactions in PTSD using human neurons reveals diagnosis-specific glucocorticoid-induced gene expression.
Nat Neurosci
; 25(11): 1434-1445, 2022 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-36266471
15.
A dual SHOX2:GFP; MYH6:mCherry knockin hESC reporter line for derivation of human SAN-like cells.
iScience
; 25(4): 104153, 2022 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-35434558
16.
A human iPSC-array-based GWAS identifies a virus susceptibility locus in the NDUFA4 gene and functional variants.
Cell Stem Cell
; 29(10): 1475-1490.e6, 2022 10 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-36206731
17.
Integrating deep learning and unbiased automated high-content screening to identify complex disease signatures in human fibroblasts.
Nat Commun
; 13(1): 1590, 2022 03 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-35338121
18.
Molecular subtyping of Alzheimer's disease using RNA sequencing data reveals novel mechanisms and targets.
Sci Adv
; 7(2)2021 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33523961
19.
Stem cell-derived neurons reflect features of protein networks, neuropathology, and cognitive outcome of their aged human donors.
Neuron
; 109(21): 3402-3420.e9, 2021 11 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-34473944
20.
Transformative Network Modeling of Multi-omics Data Reveals Detailed Circuits, Key Regulators, and Potential Therapeutics for Alzheimer's Disease.
Neuron
; 109(2): 257-272.e14, 2021 01 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-33238137