Detalhe da pesquisa
1.
Loss of the intracellular enzyme QPCTL limits chemokine function and reshapes myeloid infiltration to augment tumor immunity.
Nat Immunol
; 23(4): 568-580, 2022 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-35314846
2.
Covalent Library Screening by Targeted Mass Spectrometry for Rapid Binding Site Identification.
Anal Chem
; 95(7): 3779-3788, 2023 02 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-36706310
3.
High-Throughput Kinetic Characterization of Irreversible Covalent Inhibitors of KRASG12C by Intact Protein MS and Targeted MRM.
Anal Chem
; 94(2): 1230-1239, 2022 01 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-34990117
4.
Characterization of Antineovascularization Activity and Ocular Pharmacokinetics of Phosphoinositide 3-Kinase/Mammalian Target of Rapamycin Inhibitor GNE-947.
Drug Metab Dispos
; 48(5): 408-419, 2020 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-32132091
5.
Discovery of a class of highly potent Janus Kinase 1/2 (JAK1/2) inhibitors demonstrating effective cell-based blockade of IL-13 signaling.
Bioorg Med Chem Lett
; 29(12): 1522-1531, 2019 06 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-30981576
6.
Fragment-based identification and optimization of a class of potent pyrrolo[2,1-f][1,2,4]triazine MAP4K4 inhibitors.
Bioorg Med Chem Lett
; 24(18): 4546-4552, 2014 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25139565
7.
A hit to lead discovery of novel N-methylated imidazolo-, pyrrolo-, and pyrazolo-pyrimidines as potent and selective mTOR inhibitors.
Bioorg Med Chem Lett
; 23(18): 5097-104, 2013 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23932790
8.
Identification of GNE-293, a potent and selective PI3Kδ inhibitor: navigating in vitro genotoxicity while improving potency and selectivity.
Bioorg Med Chem Lett
; 23(17): 4953-9, 2013 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23867164
9.
Cis-amide isosteric replacement in thienobenzoxepin inhibitors of PI3-kinase.
Bioorg Med Chem Lett
; 23(3): 897-901, 2013 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23265894
10.
Discovery of thiazolobenzoxepin PI3-kinase inhibitors that spare the PI3-kinase ß isoform.
Bioorg Med Chem Lett
; 23(9): 2606-13, 2013 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23540645
11.
Potent and selective inhibitors of PI3Kδ: obtaining isoform selectivity from the affinity pocket and tryptophan shelf.
Bioorg Med Chem Lett
; 22(13): 4296-302, 2012 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22672799
12.
Structure-based design of thienobenzoxepin inhibitors of PI3-kinase.
Bioorg Med Chem Lett
; 21(13): 4054-8, 2011 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21636270
13.
Native Mass Spectrometry for the Study of PROTAC GNE-987-Containing Ternary Complexes.
ChemMedChem
; 16(14): 2206-2210, 2021 07 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-33792163
14.
Identification of GNE-477, a potent and efficacious dual PI3K/mTOR inhibitor.
Bioorg Med Chem Lett
; 20(8): 2408-11, 2010 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20346656
15.
Structure-based optimization of pyrazolo-pyrimidine and -pyridine inhibitors of PI3-kinase.
Bioorg Med Chem Lett
; 20(20): 6048-51, 2010 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20822905
16.
Preclinical characterization of PF-00868554, a potent nonnucleoside inhibitor of the hepatitis C virus RNA-dependent RNA polymerase.
Antimicrob Agents Chemother
; 53(6): 2544-52, 2009 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-19307358
17.
Pharmacologic properties of AG-012986, a pan-cyclin-dependent kinase inhibitor with antitumor efficacy.
Mol Cancer Ther
; 7(4): 818-28, 2008 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-18413795
18.
Discovery of Peptidomimetic Antibody-Drug Conjugate Linkers with Enhanced Protease Specificity.
J Med Chem
; 61(3): 989-1000, 2018 02 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-29227683
19.
Design of Selective Benzoxazepin PI3Kδ Inhibitors Through Control of Dihedral Angles.
ACS Med Chem Lett
; 8(9): 936-940, 2017 Sep 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-28947940
20.
Discovery of Clinical Development Candidate GDC-0084, a Brain Penetrant Inhibitor of PI3K and mTOR.
ACS Med Chem Lett
; 7(4): 351-6, 2016 Apr 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-27096040