Detalhe da pesquisa
1.
Halogen Bond Interactions of Novel HIV-1 Protease Inhibitors (PI) (GRL-001-15 and GRL-003-15) with the Flap of Protease Are Critical for Their Potent Activity against Wild-Type HIV-1 and Multi-PI-Resistant Variants.
Antimicrob Agents Chemother
; 63(6)2019 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-30962341
2.
Co(II)-salen catalyzed stereoselective cyclopropanation of fluorinated styrenes.
Chirality
; 31(12): 1014-1027, 2019 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-31680333
3.
Design of novel HIV-1 protease inhibitors incorporating isophthalamide-derived P2-P3 ligands: Synthesis, biological evaluation and X-ray structural studies of inhibitor-HIV-1 protease complex.
Bioorg Med Chem
; 25(19): 5114-5127, 2017 10 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28434781
4.
Total syntheses of both enantiomers of amphirionin 4: A chemoenzymatic based strategy for functionalized tetrahydrofurans.
Tetrahedron
; 73(14): 1820-1830, 2017 Apr 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-28970641
5.
Ligand-induced Dimerization of Middle East Respiratory Syndrome (MERS) Coronavirus nsp5 Protease (3CLpro): IMPLICATIONS FOR nsp5 REGULATION AND THE DEVELOPMENT OF ANTIVIRALS.
J Biol Chem
; 290(32): 19403-22, 2015 Aug 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-26055715
6.
A novel tricyclic ligand-containing nonpeptidic HIV-1 protease inhibitor, GRL-0739, effectively inhibits the replication of multidrug-resistant HIV-1 variants and has a desirable central nervous system penetration property in vitro.
Antimicrob Agents Chemother
; 59(5): 2625-35, 2015 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-25691652
7.
X-ray structure and inhibition of the feline infectious peritonitis virus 3C-like protease: Structural implications for drug design.
Bioorg Med Chem Lett
; 25(22): 5072-7, 2015 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26592814
8.
Design, synthesis, biological evaluation and X-ray structural studies of HIV-1 protease inhibitors containing substituted fused-tetrahydropyranyl tetrahydrofuran as P2-ligands.
Org Biomol Chem
; 13(48): 11607-21, 2015 Dec 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-26462551
9.
Zinc catalyzed and mediated asymmetric propargylation of trifluoromethyl ketones with a propargyl boronate.
J Org Chem
; 78(8): 3592-615, 2013 Apr 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-23544787
10.
OGG1 and MUTYH repair activities promote telomeric 8-oxoguanine induced cellular senescence.
bioRxiv
; 2023 Apr 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-37090589
11.
Single atom changes in newly synthesized HIV protease inhibitors reveal structural basis for extreme affinity, high genetic barrier, and adaptation to the HIV protease plasticity.
Sci Rep
; 10(1): 10664, 2020 06 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-32606378
12.
Design of Highly Potent, Dual-Acting and Central-Nervous-System-Penetrating HIV-1 Protease Inhibitors with Excellent Potency against Multidrug-Resistant HIV-1 Variants.
ChemMedChem
; 13(8): 803-815, 2018 04 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-29437300
13.
Design and Development of Highly Potent HIV-1 Protease Inhibitors with a Crown-Like Oxotricyclic Core as the P2-Ligand To Combat Multidrug-Resistant HIV Variants.
J Med Chem
; 60(10): 4267-4278, 2017 05 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-28418652
14.
A novel central nervous system-penetrating protease inhibitor overcomes human immunodeficiency virus 1 resistance with unprecedented aM to pM potency.
Elife
; 62017 10 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-29039736
15.
Enantioselective Total Synthesis of (+)-Amphirionin-4.
Org Lett
; 18(9): 2296-9, 2016 05 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-27116318
16.
Highly potent HIV-1 protease inhibitors with novel tricyclic P2 ligands: design, synthesis, and protein-ligand X-ray studies.
J Med Chem
; 56(17): 6792-802, 2013 Sep 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-23947685
17.
Correction to Enantioselective Total Synthesis of (+)-Amphirionin-4.
Org Lett
; 18(14): 3509, 2016 07 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27333151