Detalhe da pesquisa
1.
AWZ1066S, a highly specific anti-Wolbachia drug candidate for a short-course treatment of filariasis.
Proc Natl Acad Sci U S A
; 116(4): 1414-1419, 2019 01 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-30617067
2.
Artemisinin inspired synthetic endoperoxide drug candidates: Design, synthesis, and mechanism of action studies.
Med Res Rev
; 41(6): 3062-3095, 2021 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-34355414
3.
Dose prediction for repurposing nitazoxanide in SARS-CoV-2 treatment or chemoprophylaxis.
Br J Clin Pharmacol
; 87(4): 2078-2088, 2021 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-33085781
4.
Synthesis of Non-symmetrical Dispiro-1,2,4,5-Tetraoxanes and Dispiro-1,2,4-Trioxanes Catalyzed by Silica Sulfuric Acid.
J Org Chem
; 86(15): 10608-10620, 2021 08 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-34279102
5.
Modification of the cyclopropyl moiety of abacavir provides insight into the structure activity relationship between HLA-B*57:01 binding and T-cell activation.
Allergy
; 75(3): 636-647, 2020 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-31549414
6.
Antimalarial Agents as Therapeutic Tools Against Toxoplasmosis-A Short Bridge between Two Distant Illnesses.
Molecules
; 25(7)2020 Mar 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-32235463
7.
Artemisinin activity-based probes identify multiple molecular targets within the asexual stage of the malaria parasites Plasmodium falciparum 3D7.
Proc Natl Acad Sci U S A
; 113(8): 2080-5, 2016 Feb 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-26858419
8.
α-Methyl-α-phenylsuccinimide ameliorates neurodegeneration in a C. elegans model of TDP-43 proteinopathy.
Neurobiol Dis
; 118: 40-54, 2018 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-29940336
9.
Synthesis and profiling of benzylmorpholine 1,2,4,5-tetraoxane analogue N205: Towards tetraoxane scaffolds with potential for single dose cure of malaria.
Bioorg Med Chem
; 26(11): 2996-3005, 2018 07 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-29779669
10.
Antimalarial 4(1H)-pyridones bind to the Qi site of cytochrome bc1.
Proc Natl Acad Sci U S A
; 112(3): 755-60, 2015 Jan 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-25564664
11.
Pyrethroid activity-based probes for profiling cytochrome P450 activities associated with insecticide interactions.
Proc Natl Acad Sci U S A
; 110(49): 19766-71, 2013 Dec 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-24248381
12.
A Click Chemistry-Based Proteomic Approach Reveals that 1,2,4-Trioxolane and Artemisinin Antimalarials Share a Common Protein Alkylation Profile.
Angew Chem Int Ed Engl
; 55(22): 6401-5, 2016 05 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-27089538
13.
Integrated transcriptomic and proteomic analyses uncover regulatory roles of Nrf2 in the kidney.
Kidney Int
; 88(6): 1261-1273, 2015 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-26422507
14.
Quinolone-Hydroxyquinoline Tautomerism in Quinolone 3-Esters. Preserving the 4-Oxoquinoline Structure To Retain Antimalarial Activity.
J Org Chem
; 80(24): 12244-57, 2015 Dec 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-26551438
15.
From hybrid compounds to targeted drug delivery in antimalarial therapy.
Bioorg Med Chem
; 23(16): 5120-30, 2015 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25913864
16.
Generation of quinolone antimalarials targeting the Plasmodium falciparum mitochondrial respiratory chain for the treatment and prophylaxis of malaria.
Proc Natl Acad Sci U S A
; 109(21): 8298-303, 2012 May 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-22566611
17.
Rapid kill of malaria parasites by artemisinin and semi-synthetic endoperoxides involves ROS-dependent depolarization of the membrane potential.
J Antimicrob Chemother
; 69(4): 1005-16, 2014 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-24335485
18.
Design, synthesis and modelling of photoreactive chemical probes for investigating target engagement of plasmepsin IX and X in Plasmodium falciparum.
RSC Chem Biol
; 5(1): 19-29, 2024 Jan 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-38179191
19.
Cytochrome b mutation Y268S conferring atovaquone resistance phenotype in malaria parasite results in reduced parasite bc1 catalytic turnover and protein expression.
J Biol Chem
; 287(13): 9731-9741, 2012 Mar 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-22282497
20.
Antimalarial pharmacology and therapeutics of atovaquone.
J Antimicrob Chemother
; 68(5): 977-85, 2013 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-23292347