[Duration-optimized therapeutic and preventive treatment courses for mining workers with the use of natural and preformed factors. Guidelines for physicians].

This manual for physicians describes a system for the treatment of primary and secondary vibration disease in mining workers optimized for the duration of therapy including the application of preformed and natural factors. The efficacy of the proposed complex of therapeutic and preventive measures in this category of patients has been estimated based on the results of retrospective and prospective studies.

[Clinical characteristics of tick-borne encephalitis complicated by Lyme borreliosis]. / Klinicheskaia kharakteristika kleshchevogo éntsefalita pri ego sochetanii s Laim-borreliozom.

Clinical characteristics of mixed tick borne encephalitis (TBE) + Lyme borrelliosis (LB) infection and monoinfections are compared. Eighty-five patients with TBE + LB mixed infection serologically verified by EIA and 87 with isolated TBE, who fell ill in 1996, were examined. Among patients with mixed infection, cases with blurred TBE predominated; severe forms (meningeal and focal) were almost two times less incident than in TBE monoinfection. Typical clinical symptoms of LB were observed in 63.5% patients, while in the rest 36.5% LB manifested only by circulation of antibodies to B. burgdorferi. Comparative analysis of patients with mixed TBE + LB infection and TBE monoinfection confirmed a more benign course of TBE during the acute period in patients with mixed infection. Mixed infection should be ruled out or confirmed by thorough clinical examinations with obligatory detection of antibodies to agents of both diseases.

[On the problem of pathomorphosis of modern tick-borne encephalitis in Ural]. / K probleme patomorfoza sovremennogo kleshchevogo éntsefalita na Urale.

Pathology study of 32 patients who died of tick-borne encephalitis (TBE) in the Ural Region in 1990s revealed differences with this infection registered in 1940-1950s. Pathological changes in the central nervous system by their severity and location are like those observed in the Far East TBE. Apart from grave alterative changes in the nerve cells of motor nuclei of the spinal cord and brain, three types of pathological changes are observed: productive inflammation, exudative inflammation without pronounced inflammatory reaction. Differences in the organism reactions to the infectious process are explained by differences in the virus virulence and organism immunological status.

[The characteristics of peripheral nervous system involvement in Lyme borreliosis in an endemic region of Russia]. / Osobennosti porazheniia perifericheskoi nervnoi sistemy pri Laim-borrelioze v éndemichnom raione Rossii.

Clinical and laboratory data are available on affection of the peripheral nervous system (PNS) in 27 patients with Lyme-borreliosis (LB) in the endemic region of Russia. PNS disorders arose early, 88.9% of the patients had them within one month of the disease. 9 (37.5%) patients had meningoradiculoneuropathy (MRN) which emerged in the acute period in 77.8% of the patients. Inflammation in the cerebrospinal fluid was registered only in patients with clinical signs of meningitis. MRN developed more frequently in facial nerve neuritis (FNN) than in radiculopathy (RP)-80.0% and 14.3%, respectively, p = 0.01. Intrathecal synthesis of antibodies to B. burgdorferi in combination with pleocytosis was found only in FNN patients (16.7%). In 6 (37.5%) of 16 patients with neuroborreliosis concentrations of C-reactive protein were elevated. Its high level occurred significantly more frequently in RP (83%) than in FNN (17%) (p = 0.05). 5 out of 14 LB patients exhibited high level of Willebrand factor antigen. No clear clinical relations between this value and PNS lesions in LB were found.

[Primary and secondary prophylaxis of vibration disease caused by local vibration in miners]. / Pervichnaia i vtorichnaia profilaktika vibratsionnoi bolezni ot vozdeistviia lokal'noi vibratsii u gornorabochikh.

The article contains data on complex balneotherapy of vibration disease caused by local vibration in high risk group (miners exposed to vibration), that help to justify use of means for primary and secondary prevention of vibration disease.

[Drug-free management of homeostasis in patients with vibration disease]. / Nemedikamentoznye metody korrektsii gomeostaza u bol'nykh vibratsionnoi bolezn'iu.

The authors present results of homeostasis studies in 239 patients having vibration disease due to local vibration and demonstrate drugs-free correction (physio- and balneotherapy) of disorders caused by vibration. High therapeutic efficiency meant improved peripheral hemodynamics of upper limbs, coagulation parameters, lipid metabolism and lipid peroxidation.

[Segmental autonomic nervous system disorders in patients with vibration disease due to local vibration]. / Segmentarnye vegetativnye narusheniia u bol'nykh vibratsionnoi bolezn'iu ot vozdeistviia lokal'noi vibratsii.

Cardiovascular tests in vibraton disease patients revealed failure of efferent vegetative paths. Degree of segmentary neurologic disorders increases as vibration disease progresses.

[The clinical picture and course of acoustic neurinoma in advanced age]. / Klinika i techenie nevrinomy slukhovogo nerva v pozhilom vozraste

Specificity marking the evolution and clinical picture of acoustic neurinoma in persons of advanced age is described. A great interest of the cases under study consists in that quite often the clinical picture and the course of the disease in this age category are atypical, this being due to the age of the patients and intercurrent, most often vascular diseases of the brain.