Pesquisa | Portal de Pesquisa da BVS Enfermagem

1.

Pharmacokinetics of the Protein Microbicide 5P12-RANTES in Sheep following Single-Dose Vaginal Gel Administration.

McBride, John W; Dias, Nicola; Cameron, David; Offord, Robin E; Hartley, Oliver; Boyd, Peter; Kett, Vicky L; Malcolm, R Karl.

Antimicrob Agents Chemother ; 61(10)2017 10.

Artigo em Inglês | MEDLINE | ID: mdl-28784672

2.

Microbicides and other topical strategies to prevent vaginal transmission of HIV.

Lederman, Michael M; Offord, Robin E; Hartley, Oliver.

Nat Rev Immunol ; 6(5): 371-82, 2006 May.

Artigo em Inglês | MEDLINE | ID: mdl-16639430

3.

A scalable low-cost cGMP process for clinical grade production of the HIV inhibitor 5P12-RANTES in Pichia pastoris.

Cerini, Fabrice; Gaertner, Hubert; Madden, Knut; Tolstorukov, Ilya; Brown, Scott; Laukens, Bram; Callewaert, Nico; Harner, Jay C; Oommen, Anna M; Harms, John T; Sump, Anthony R; Sealock, Robert C; Peterson, Dustin J; Johnson, Scott K; Abramson, Stephan B; Meagher, Michael; Offord, Robin; Hartley, Oliver.

Protein Expr Purif ; 119: 1-10, 2016 Mar.

Artigo em Inglês | MEDLINE | ID: mdl-26506568

4.

Heat-Stable Dry Powder Oxytocin Formulations for Delivery by Oral Inhalation.

Fabio, Karine; Curley, Kieran; Guarneri, Joseph; Adamo, Benoit; Laurenzi, Brendan; Grant, Marshall; Offord, Robin; Kraft, Kelly; Leone-Bay, Andrea.

AAPS PharmSciTech ; 16(6): 1299-306, 2015 Dec.

Artigo em Inglês | MEDLINE | ID: mdl-25776985

5.

CCR5 mutations distinguish N-terminal modifications of RANTES (CCL5) with agonist versus antagonist activity.

Choi, Won-Tak; Nedellec, Rebecca; Coetzer, Mia; Colin, Philippe; Lagane, Bernard; Offord, Robin E; Hartley, Oliver; Mosier, Donald E.

J Virol ; 86(18): 10218-20, 2012 Sep.

Artigo em Inglês | MEDLINE | ID: mdl-22787219

6.

Circulating human CD4 and CD8 T cells do not have large intracellular pools of CCR5.

Pilch-Cooper, Heather A; Sieg, Scott F; Hope, Thomas J; Koons, Ann; Escola, Jean-Michel; Offord, Robin; Veazey, Ronald S; Mosier, Donald E; Clagett, Brian; Medvik, Kathy; Jadlowsky, Julie K; Chance, Mark R; Kiselar, Janna G; Hoxie, James A; Collman, Ronald G; Riddick, Nadeene E; Mercanti, Valentina; Hartley, Oliver; Lederman, Michael M.

Blood ; 118(4): 1015-9, 2011 Jul 28.

Artigo em Inglês | MEDLINE | ID: mdl-21068438

7.

Using glycosaminoglycan/chemokine interactions for the long-term delivery of 5P12-RANTES in HIV prevention.

Wang, Nick X; Sieg, Scott F; Lederman, Michael M; Offord, Robin E; Hartley, Oliver; von Recum, Horst A.

Mol Pharm ; 10(10): 3564-73, 2013 Oct 07.

Artigo em Inglês | MEDLINE | ID: mdl-23859720

8.

"Resistance" to PSC-RANTES revisited: two mutations in human immunodeficiency virus type 1 HIV-1 SF162 or simian-human immunodeficiency virus SHIV SF162-p3 do not confer resistance.

Nedellec, Rebecca; Coetzer, Mia; Lederman, Michael M; Offord, Robin E; Hartley, Oliver; Mosier, Donald E.

J Virol ; 84(11): 5842-5, 2010 Jun.

Artigo em Inglês | MEDLINE | ID: mdl-20335248

9.

Highly potent, fully recombinant anti-HIV chemokines: reengineering a low-cost microbicide.

Gaertner, Hubert; Cerini, Fabrice; Escola, Jean-Michel; Kuenzi, Gabriel; Melotti, Astrid; Offord, Robin; Rossitto-Borlat, Irène; Nedellec, Rebecca; Salkowitz, Janelle; Gorochov, Guy; Mosier, Donald; Hartley, Oliver.

Proc Natl Acad Sci U S A ; 105(46): 17706-11, 2008 Nov 18.

Artigo em Inglês | MEDLINE | ID: mdl-19004761

10.

Establishing a service to tackle problematic polypharmacy.

Bennett, Frances; Shah, Neha; Offord, Robin; Ferner, Robin; Sofat, Reecha.

Future Healthc J ; 7(3): 208-211, 2020 Oct.

Artigo em Inglês | MEDLINE | ID: mdl-33094229

11.

The next lease of life.

Offord, Robin.

Health Serv J ; 124(6413): Suppl 7, 2014 Sep 05.

Artigo em Inglês | MEDLINE | ID: mdl-25509485

12.

Vaginal rings with exposed cores for sustained delivery of the HIV CCR5 inhibitor 5P12-RANTES.

McBride, John W; Boyd, Peter; Dias, Nicola; Cameron, David; Offord, Robin E; Hartley, Oliver; Kett, Vicky L; Malcolm, R Karl.

J Control Release ; 298: 1-11, 2019 03 28.

Artigo em Inglês | MEDLINE | ID: mdl-30731150

13.

Development and pharmacokinetics of a combination vaginal ring for sustained release of dapivirine and the protein microbicide 5P12-RANTES.

McBride, John W; Malcolm, R Karl; Dias, Nicola; Cameron, David; Offord, Robin E; Hartley, Oliver; Kett, Vicky L; Devlin, Brid; Boyd, Peter.

Int J Pharm ; 564: 207-213, 2019 Jun 10.

Artigo em Inglês | MEDLINE | ID: mdl-30999049

14.

Highly potent HIV inhibition: engineering a key anti-HIV structure from PSC-RANTES into MIP-1 beta/CCL4.

Gaertner, Hubert; Lebeau, Olivier; Borlat, Irène; Cerini, Fabrice; Dufour, Brigitte; Kuenzi, Gabriel; Melotti, Astrid; Fish, Richard J; Offord, Robin; Springael, Jean-Yves; Parmentier, Marc; Hartley, Oliver.

Protein Eng Des Sel ; 21(2): 65-72, 2008 Feb.

Artigo em Inglês | MEDLINE | ID: mdl-18178567

15.

Stability of 5P12-RANTES, A Candidate Rectal Microbicide, in Human Rectal Lavage.

Cerini, Fabrice; Offord, Robin; McGowan, Ian; Hartley, Oliver.

AIDS Res Hum Retroviruses ; 33(8): 768-777, 2017 08.

Artigo em Inglês | MEDLINE | ID: mdl-28177261

16.

Engineering chemokines to develop optimized HIV inhibitors.

Hartley, Oliver; Offord, Robin E.

Curr Protein Pept Sci ; 6(3): 207-19, 2005 Jun.

Artigo em Inglês | MEDLINE | ID: mdl-15974948

17.

Resistance to the CCR5 inhibitor 5P12-RANTES requires a difficult evolution from CCR5 to CXCR4 coreceptor use.

Nedellec, Rebecca; Coetzer, Mia; Lederman, Michael M; Offord, Robin E; Hartley, Oliver; Mosier, Donald E.

PLoS One ; 6(7): e22020, 2011.

Artigo em Inglês | MEDLINE | ID: mdl-21760945

18.

Comparative proteomic study of the venom of the piscivorous cone snail Conus consors.

Biass, Daniel; Dutertre, Sébastien; Gerbault, Alain; Menou, Jean-Louis; Offord, Robin; Favreau, Philippe; Stöcklin, Reto.

J Proteomics ; 72(2): 210-8, 2009 Mar 06.

Artigo em Inglês | MEDLINE | ID: mdl-19457347

19.

Topically applied recombinant chemokine analogues fully protect macaques from vaginal simian-human immunodeficiency virus challenge.

Veazey, Ronald S; Ling, Binhua; Green, Linda C; Ribka, Erin P; Lifson, Jeffrey D; Piatak, Michael; Lederman, Michael M; Mosier, Donald; Offord, Robin; Hartley, Oliver.

J Infect Dis ; 199(10): 1525-7, 2009 May 15.

Artigo em Inglês | MEDLINE | ID: mdl-19331577

20.

Semisynthetic analogues of PSC-RANTES, a potent anti-HIV protein.

Gaertner, Hubert; Offord, Robin; Botti, Paolo; Kuenzi, Gabriel; Hartley, Oliver.

Bioconjug Chem ; 19(2): 480-9, 2008 Feb.

Artigo em Inglês | MEDLINE | ID: mdl-18179159

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