Detalhe da pesquisa
1.
Pimitespib for the treatment of advanced gastrointestinal stromal tumors and other tumors.
Future Oncol
; 20(9): 507-519, 2024 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-38050698
2.
Combination of pimitespib (TAS-116) with sunitinib is an effective therapy for imatinib-resistant gastrointestinal stromal tumors.
Int J Cancer
; 152(12): 2580-2593, 2023 06 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-36752576
3.
Characterization of cell line with dedifferentiated GIST-like features established from cecal GIST of familial GIST model mice.
Pathol Int
; 73(5): 181-187, 2023 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-36825754
4.
dUTPase inhibition confers susceptibility to a thymidylate synthase inhibitor in DNA-repair-defective human cancer cells.
Cancer Sci
; 112(1): 422-432, 2021 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-33140501
5.
Pimitespib is effective on cecal GIST in a mouse model of familial GISTs with KIT-Asp820Tyr mutation through KIT signaling inhibition.
Exp Mol Pathol
; 123: 104692, 2021 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-34606780
6.
Genome editing of Nf1, Pten, and Trp53 in neonatal mice induces glioblastomas positive for oligodendrocyte lineage transcription factor 2.
J Toxicol Pathol
; 34(4): 359-365, 2021 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-34629735
7.
Acquired resistance to trastuzumab/pertuzumab or to T-DM1 in vivo can be overcome by HER2 kinase inhibition with TAS0728.
Cancer Sci
; 111(6): 2123-2131, 2020 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-32248641
8.
TAS-116 inhibits oncogenic KIT signalling on the Golgi in both imatinib-naïve and imatinib-resistant gastrointestinal stromal tumours.
Br J Cancer
; 122(5): 658-667, 2020 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-31857719
9.
Activity of TAS4464, a novel NEDD8 activating enzyme E1 inhibitor, against multiple myeloma via inactivation of nuclear factor κB pathways.
Cancer Sci
; 110(12): 3802-3810, 2019 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-31583781
10.
Functionally distinct Gata3/Chd4 complexes coordinately establish T helper 2 (Th2) cell identity.
Proc Natl Acad Sci U S A
; 110(12): 4691-6, 2013 Mar 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-23471993
11.
TAS0612, a Novel RSK, AKT, and S6K Inhibitor, Exhibits Antitumor Effects in Preclinical Tumor Models.
Mol Cancer Ther
; 23(2): 174-186, 2024 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-37906695
12.
Phosphate-activated glutaminase (GLS2), a p53-inducible regulator of glutamine metabolism and reactive oxygen species.
Proc Natl Acad Sci U S A
; 107(16): 7461-6, 2010 Apr 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-20351271
13.
Modulation of tumor immune microenvironment by TAS-115, a multi-receptor tyrosine kinase inhibitor, promotes antitumor immunity and contributes anti-PD-1 antibody therapy.
Sci Rep
; 13(1): 8821, 2023 05 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-37258621
14.
Vepafestinib is a pharmacologically advanced RET-selective inhibitor with high CNS penetration and inhibitory activity against RET solvent front mutations.
Nat Cancer
; 4(9): 1345-1361, 2023 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-37743366
15.
Thermodynamic Dissection of Potency and Selectivity of Cytosolic Hsp90 Inhibitors.
J Med Chem
; 64(5): 2669-2677, 2021 03 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-33621080
16.
TAS4464, a NEDD8-activating enzyme inhibitor, activates both intrinsic and extrinsic apoptotic pathways via c-Myc-mediated regulation in acute myeloid leukemia.
Oncogene
; 40(7): 1217-1230, 2021 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-33420360
17.
Pharmacologic dissection of the overlapping impact of heat shock protein family members on platelet function.
J Thromb Haemost
; 18(5): 1197-1209, 2020 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-32022992
18.
Efficacy and safety of TAS-116, an oral inhibitor of heat shock protein 90, in patients with metastatic or unresectable gastrointestinal stromal tumour refractory to imatinib, sunitinib and regorafenib: a phase II, single-arm trial.
Eur J Cancer
; 121: 29-39, 2019 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-31536852
19.
TAS0728, A Covalent-binding, HER2-selective Kinase Inhibitor Shows Potent Antitumor Activity in Preclinical Models.
Mol Cancer Ther
; 18(4): 733-742, 2019 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-30787176
20.
TAS4464, A Highly Potent and Selective Inhibitor of NEDD8-Activating Enzyme, Suppresses Neddylation and Shows Antitumor Activity in Diverse Cancer Models.
Mol Cancer Ther
; 18(7): 1205-1216, 2019 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-31092565