Detalhe da pesquisa
1.
Topoisomerase II poisons inhibit vertebrate DNA replication through distinct mechanisms.
EMBO J
; 41(12): e110632, 2022 06 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-35578785
2.
Basis for the discrimination of supercoil handedness during DNA cleavage by human and bacterial type II topoisomerases.
Nucleic Acids Res
; 51(8): 3888-3902, 2023 05 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-36999602
3.
No Time to Relax and Unwind: Exploration of Topoisomerases and a Growing Field of Study.
Int J Mol Sci
; 24(17)2023 Aug 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-37685888
4.
Telling Your Right Hand from Your Left: The Effects of DNA Supercoil Handedness on the Actions of Type II Topoisomerases.
Int J Mol Sci
; 24(13)2023 Jul 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-37446377
5.
Actions of a Novel Bacterial Topoisomerase Inhibitor against Neisseria gonorrhoeae Gyrase and Topoisomerase IV: Enhancement of Double-Stranded DNA Breaks.
Int J Mol Sci
; 24(15)2023 Jul 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-37569485
6.
Recognition of DNA Supercoil Handedness during Catenation Catalyzed by Type II Topoisomerases.
Biochemistry
; 61(19): 2148-2158, 2022 10 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-36122251
7.
Topoisomerase II Poisons: Converting Essential Enzymes into Molecular Scissors.
Biochemistry
; 60(21): 1630-1641, 2021 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34008964
8.
1,2-Naphthoquinone as a Poison of Human Type II Topoisomerases.
Chem Res Toxicol
; 34(4): 1082-1090, 2021 04 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-33760604
9.
Genome-wide TOP2A DNA cleavage is biased toward translocated and highly transcribed loci.
Genome Res
; 27(7): 1238-1249, 2017 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-28385713
10.
Coupling the core of the anticancer drug etoposide to an oligonucleotide induces topoisomerase II-mediated cleavage at specific DNA sequences.
Nucleic Acids Res
; 46(5): 2218-2233, 2018 03 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-29447373
11.
Bimodal Actions of a Naphthyridone/Aminopiperidine-Based Antibacterial That Targets Gyrase and Topoisomerase IV.
Biochemistry
; 58(44): 4447-4455, 2019 11 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-31617352
12.
6,6'-Dihydroxythiobinupharidine as a poison of human type II topoisomerases.
Bioorg Med Chem Lett
; 29(15): 1881-1885, 2019 08 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31182315
13.
Smoothed Potential MD Simulations for Dissociation Kinetics of Etoposide To Unravel Isoform Specificity in Targeting Human Topoisomerase II.
J Chem Inf Model
; 59(9): 4007-4017, 2019 09 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-31449404
14.
Activities of gyrase and topoisomerase IV on positively supercoiled DNA.
Nucleic Acids Res
; 45(16): 9611-9624, 2017 Sep 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-28934496
15.
Interlinked DNA nano-circles for measuring topoisomerase II activity at the level of single decatenation events.
Nucleic Acids Res
; 45(13): 7855-7869, 2017 Jul 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-28541438
16.
Fluoroquinolone interactions with Mycobacterium tuberculosis gyrase: Enhancing drug activity against wild-type and resistant gyrase.
Proc Natl Acad Sci U S A
; 113(7): E839-46, 2016 Feb 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-26792518
17.
Polyamine-containing etoposide derivatives as poisons of human type II topoisomerases: Differential effects on topoisomerase IIα and IIß.
Bioorg Med Chem Lett
; 28(17): 2961-2968, 2018 09 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-30006062
18.
Recognition of DNA Supercoil Geometry by Mycobacterium tuberculosis Gyrase.
Biochemistry
; 56(40): 5440-5448, 2017 10 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-28921956
19.
Interactions between Quinolones and Bacillus anthracis Gyrase and the Basis of Drug Resistance.
Biochemistry
; 56(32): 4191-4200, 2017 08 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28708938
20.
Novel trifluoromethylated 9-amino-3,4-dihydroacridin-1(2H)-ones act as covalent poisons of human topoisomerase IIα.
Bioorg Med Chem Lett
; 27(3): 586-589, 2017 02 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27998679