Detalhe da pesquisa
1.
Discovery of GLPG3667, a Selective ATP Competitive Tyrosine Kinase 2 Inhibitor for the Treatment of Autoimmune Diseases.
J Med Chem
; 67(11): 8545-8568, 2024 Jun 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-38805213
2.
IRAK4 inhibition dampens pathogenic processes driving inflammatory skin diseases.
Sci Transl Med
; 15(683): eabj3289, 2023 02 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-36791209
3.
Discovery of the S1P2 Antagonist GLPG2938 (1-[2-Ethoxy-6-(trifluoromethyl)-4-pyridyl]-3-[[5-methyl-6-[1-methyl-3-(trifluoromethyl)pyrazol-4-yl]pyridazin-3-yl]methyl]urea), a Preclinical Candidate for the Treatment of Idiopathic Pulmonary Fibrosis.
J Med Chem
; 64(9): 6037-6058, 2021 05 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-33939425
4.
Discovery and Optimization of Orally Bioavailable Phthalazone and Cinnolone Carboxylic Acid Derivatives as S1P2 Antagonists against Fibrotic Diseases.
J Med Chem
; 64(19): 14557-14586, 2021 10 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-34581584
5.
Discovery of 9-Cyclopropylethynyl-2-((S)-1-[1,4]dioxan-2-ylmethoxy)-6,7-dihydropyrimido[6,1-a]isoquinolin-4-one (GLPG1205), a Unique GPR84 Negative Allosteric Modulator Undergoing Evaluation in a Phase II Clinical Trial.
J Med Chem
; 63(22): 13526-13545, 2020 11 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-32902984
6.
Role of dietary phosphorus and degree of uremia in the development of renal bone disease in rats.
Ren Fail
; 29(1): 1-12, 2007.
Artigo
em Inglês
| MEDLINE | ID: mdl-17365904
7.
Discovery of 2-[[2-Ethyl-6-[4-[2-(3-hydroxyazetidin-1-yl)-2-oxoethyl]piperazin-1-yl]-8-methylimidazo[1,2-a]pyridin-3-yl]methylamino]-4-(4-fluorophenyl)thiazole-5-carbonitrile (GLPG1690), a First-in-Class Autotaxin Inhibitor Undergoing Clinical Evaluation for the Treatment of Idiopathic Pulmonary Fibrosis.
J Med Chem
; 60(9): 3580-3590, 2017 05 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-28414242
8.
Development and reversibility of impaired mineralization associated with lanthanum carbonate treatment in chronic renal failure rats.
Bone
; 38(6): 803-10, 2006 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-16412714
9.
Discovery and optimization of an azetidine chemical series as a free fatty acid receptor 2 (FFA2) antagonist: from hit to clinic.
J Med Chem
; 57(23): 10044-57, 2014 Dec 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-25380412
10.
A multiparameter approach to monitor disease activity in collagen-induced arthritis.
Arthritis Res Ther
; 12(4): R160, 2010.
Artigo
em Inglês
| MEDLINE | ID: mdl-20731827
11.
Localization of lanthanum in bone of chronic renal failure rats after oral dosing with lanthanum carbonate.
Kidney Int
; 67(5): 1830-6, 2005 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-15840030
12.
Time-evolution and reversibility of strontium-induced osteomalacia in chronic renal failure rats.
Kidney Int
; 67(3): 920-30, 2005 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-15698431