Detalhe da pesquisa
1.
Ablating the Rab-GTPase activating protein TBC1D1 predisposes rats to high-fat diet-induced cardiomyopathy.
J Physiol
; 598(4): 683-697, 2020 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-31845331
2.
Long-term, high-fat feeding exacerbates short-term increases in adipose mitochondrial reactive oxygen species, without impairing mitochondrial respiration.
Am J Physiol Endocrinol Metab
; 319(2): E376-E387, 2020 08 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32543945
3.
QT Assessment in Early Drug Development: The Long and the Short of It.
Int J Mol Sci
; 20(6)2019 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-30884748
4.
Ablating the protein TBC1D1 impairs contraction-induced sarcolemmal glucose transporter 4 redistribution but not insulin-mediated responses in rats.
J Biol Chem
; 292(40): 16653-16664, 2017 10 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-28808062
5.
Clinical assessment of hepatic de novo lipogenesis in non-alcoholic fatty liver disease.
Lipids Health Dis
; 15(1): 159, 2016 Sep 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-27640119
6.
In adipose tissue, increased mitochondrial emission of reactive oxygen species is important for short-term high-fat diet-induced insulin resistance in mice.
Diabetologia
; 58(5): 1071-80, 2015 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-25754553
7.
Deletion of ARNT/HIF1ß in pancreatic beta cells does not impair glucose homeostasis in mice, but is associated with defective glucose sensing ex vivo.
Diabetologia
; 58(12): 2832-42, 2015 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-26409461
8.
Extremely rapid increase in fatty acid transport and intramyocellular lipid accumulation but markedly delayed insulin resistance after high fat feeding in rats.
Diabetologia
; 58(10): 2381-91, 2015 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-26197708
9.
Should You Run a Dedicated TQT Study? Sponsor and Regulatory Considerations on Substitution Pathways to Assess QT Liability.
Clin Pharmacol Ther
; 2024 May 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-38698592
10.
The Impact of N-nitrosamine Impurities on Clinical Drug Development.
J Pharm Sci
; 112(5): 1183-1191, 2023 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-36706834
11.
Rifampin Drug-Drug-Interaction Studies: Reflections on the Nitrosamine Impurities Issue.
Clin Pharmacol Ther
; 113(4): 816-821, 2023 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-35593029
12.
Prevalence of Baseline Cardiac Arrhythmias in Participants with Overweight or Obesity in Phase 1 Clinical Trials: Analysis of 24-Hour Holter Electrocardiogram Recordings.
J Clin Pharmacol
; 63(5): 539-543, 2023 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-36524539
13.
Evaluation of chylomicron effect on ASP production in 3T3-L1 adipocytes.
Acta Biochim Biophys Sin (Shanghai)
; 43(2): 154-9, 2011 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-21266544
14.
Elevated sensitivity to diet-induced obesity and insulin resistance in mice lacking 4E-BP1 and 4E-BP2.
J Clin Invest
; 117(2): 387-96, 2007 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-17273556
15.
Effects of bezafibrate treatment in a patient and a carrier with mutations in the PNPLA2 gene, causing neutral lipid storage disease with myopathy.
Circ Res
; 112(5): e51-4, 2013 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23449549
16.
The effects of acylation stimulating protein supplementation VS antibody neutralization on energy expenditure in wildtype mice.
BMC Physiol
; 10: 4, 2010 Apr 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-20416070
17.
Adipose Tissue Inflammation Is Directly Linked to Obesity-Induced Insulin Resistance, while Gut Dysbiosis and Mitochondrial Dysfunction Are Not Required.
Function (Oxf)
; 1(2): zqaa013, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-34278304
18.
Review of Drug Development Guidance to Treat Chronic Obstructive Pulmonary Disease: US and EU Perspectives.
Clin Pharmacol Ther
; 106(6): 1222-1235, 2019 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-31334840
19.
Translatability of the S7A core battery respiratory safety pharmacology studies: Preclinical respiratory and related clinical adverse events.
J Pharmacol Toxicol Methods
; 99: 106596, 2019.
Artigo
em Inglês
| MEDLINE | ID: mdl-31173885
20.
Assay validation and clinical performance of chronic inflammatory and chemokine biomarkers of NASH fibrosis.
PLoS One
; 14(7): e0217263, 2019.
Artigo
em Inglês
| MEDLINE | ID: mdl-31291245