Detalhe da pesquisa
1.
Modeling Heartland virus disease in mice and therapeutic intervention with 4'-fluorouridine.
J Virol
; 98(4): e0013224, 2024 Apr 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-38511932
2.
4'-Fluorouridine mitigates lethal infection with pandemic human and highly pathogenic avian influenza viruses.
PLoS Pathog
; 19(4): e1011342, 2023 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-37068076
3.
Human Safety, Tolerability, and Pharmacokinetics of Molnupiravir, a Novel Broad-Spectrum Oral Antiviral Agent with Activity Against SARS-CoV-2.
Antimicrob Agents Chemother
; 65(5)2021 05 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33649113
4.
Analysis of the Potential for N4-Hydroxycytidine To Inhibit Mitochondrial Replication and Function.
Antimicrob Agents Chemother
; 64(2)2020 01 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-31767721
5.
Small-Molecule Antiviral ß-d-N4-Hydroxycytidine Inhibits a Proofreading-Intact Coronavirus with a High Genetic Barrier to Resistance.
J Virol
; 93(24)2019 12 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-31578288
6.
ß-d-N4-Hydroxycytidine Is a Potent Anti-alphavirus Compound That Induces a High Level of Mutations in the Viral Genome.
J Virol
; 92(3)2018 02 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29167335
7.
Simple In Vitro Assay To Evaluate the Incorporation Efficiency of Ribonucleotide Analog 5'-Triphosphates into RNA by Human Mitochondrial DNA-Dependent RNA Polymerase.
Antimicrob Agents Chemother
; 62(2)2018 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-29180528
8.
Orally Efficacious Broad-Spectrum Ribonucleoside Analog Inhibitor of Influenza and Respiratory Syncytial Viruses.
Antimicrob Agents Chemother
; 62(8)2018 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-29891600
9.
Analysis of Ribonucleotide 5'-Triphosphate Analogs as Potential Inhibitors of Zika Virus RNA-Dependent RNA Polymerase by Using Nonradioactive Polymerase Assays.
Antimicrob Agents Chemother
; 61(3)2017 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-27993851
10.
Discovery and Development of the Anti-Human Immunodeficiency Virus Drug, Emtricitabine (Emtriva, FTC).
Acc Chem Res
; 49(10): 2091-2098, 2016.
Artigo
em Inglês
| MEDLINE | ID: mdl-27704821
11.
4'-Fluorouridine inhibits alphavirus replication and infection in vitro and in vivo.
mBio
; : e0042024, 2024 May 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-38700353
12.
The prophylactic and therapeutic efficacy of the broadly active antiviral ribonucleoside N4-Hydroxycytidine (EIDD-1931) in a mouse model of lethal Ebola virus infection.
Antiviral Res
; 209: 105453, 2023 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36379378
13.
Comparing molnupiravir and nirmatrelvir/ritonavir efficacy and the effects on SARS-CoV-2 transmission in animal models.
Nat Commun
; 14(1): 4731, 2023 08 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-37550333
14.
SARS-CoV-2 variant of concern type and biological sex affect efficacy of molnupiravir in dwarf hamster model of severe COVID-19.
bioRxiv
; 2022 Feb 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-35169793
15.
SARS-CoV-2 VOC type and biological sex affect molnupiravir efficacy in severe COVID-19 dwarf hamster model.
Nat Commun
; 13(1): 4416, 2022 07 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-35906230
16.
Paxlovid-like nirmatrelvir/ritonavir fails to block SARS-CoV-2 transmission in ferrets.
bioRxiv
; 2022 Nov 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-36451893
17.
4'-Fluorouridine is an oral antiviral that blocks respiratory syncytial virus and SARS-CoV-2 replication.
Science
; 375(6577): 161-167, 2022 Jan 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-34855509
18.
Hexadecyloxypropyl-cidofovir, CMX001, prevents adenovirus-induced mortality in a permissive, immunosuppressed animal model.
Proc Natl Acad Sci U S A
; 105(20): 7293-7, 2008 May 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-18490659
19.
Efficacy of CMX001 against herpes simplex virus infections in mice and correlations with drug distribution studies.
J Infect Dis
; 202(10): 1492-9, 2010 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20923374
20.
Developing a direct acting, orally available antiviral agent in a pandemic: the evolution of molnupiravir as a potential treatment for COVID-19.
Curr Opin Virol
; 50: 17-22, 2021 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-34271264