Detalhe da pesquisa
1.
Ginsenoside Rb1 inhibits fibrillation and toxicity of alpha-synuclein and disaggregates preformed fibrils.
Neurobiol Dis
; 74: 89-101, 2015 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-25449909
2.
Generation and characterization of novel conformation-specific monoclonal antibodies for α-synuclein pathology.
Neurobiol Dis
; 79: 81-99, 2015 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-25937088
3.
Mimicking phosphorylation at serine 87 inhibits the aggregation of human α-synuclein and protects against its toxicity in a rat model of Parkinson's disease.
J Neurosci
; 32(5): 1536-44, 2012 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22302797
4.
α-Synuclein aggregation and modulating factors.
Subcell Biochem
; 65: 109-64, 2012.
Artigo
em Inglês
| MEDLINE | ID: mdl-23225002
5.
Assessment of the Anti-Amyloidogenic Properties of Essential Oils and Their Constituents in Cells Using a Whole-Cell Recombinant Biosensor.
Brain Sci
; 14(1)2023 Dec 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-38248250
6.
Phosphorylation at S87 is enhanced in synucleinopathies, inhibits alpha-synuclein oligomerization, and influences synuclein-membrane interactions.
J Neurosci
; 30(9): 3184-98, 2010 Mar 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-20203178
7.
Entacapone and tolcapone, two catechol O-methyltransferase inhibitors, block fibril formation of alpha-synuclein and beta-amyloid and protect against amyloid-induced toxicity.
J Biol Chem
; 285(20): 14941-14954, 2010 May 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-20150427
8.
Phosphorylation of synucleins by members of the Polo-like kinase family.
J Biol Chem
; 285(4): 2807-22, 2010 Jan 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-19889641
9.
Detection of elevated levels of soluble alpha-synuclein oligomers in post-mortem brain extracts from patients with dementia with Lewy bodies.
Brain
; 132(Pt 4): 1093-101, 2009 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-19155272
10.
Inhibition of alpha-synuclein seeded fibril formation and toxicity by herbal medicinal extracts.
BMC Complement Med Ther
; 20(1): 73, 2020 Mar 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-32143619
11.
Detection of oligomeric forms of alpha-synuclein protein in human plasma as a potential biomarker for Parkinson's disease.
FASEB J
; 20(3): 419-25, 2006 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-16507759
12.
Alpha-synuclein implicated in Parkinson's disease is present in extracellular biological fluids, including human plasma.
FASEB J
; 17(13): 1945-7, 2003 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-14519670
13.
A strategy for designing inhibitors of alpha-synuclein aggregation and toxicity as a novel treatment for Parkinson's disease and related disorders.
FASEB J
; 18(11): 1315-7, 2004 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-15180968
14.
Alpha-synuclein and the pathogenesis of Parkinson's disease.
Protein Pept Lett
; 11(3): 229-37, 2004 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-15182224
15.
Elevated levels of cerebrospinal fluid α-synuclein oligomers in healthy asymptomatic LRRK2 mutation carriers.
Front Aging Neurosci
; 6: 248, 2014.
Artigo
em Inglês
| MEDLINE | ID: mdl-25309429
16.
Structure activity relationship of phenolic acid inhibitors of α-synuclein fibril formation and toxicity.
Front Aging Neurosci
; 6: 197, 2014.
Artigo
em Inglês
| MEDLINE | ID: mdl-25140150
17.
Designing peptide inhibitors for oligomerization and toxicity of Alzheimer's beta-amyloid peptide.
Biochemistry
; 47(7): 1984-92, 2008 Feb 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-18189413
18.
Inhibition of alpha-synuclein fibrillization by dopamine is mediated by interactions with five C-terminal residues and with E83 in the NAC region.
PLoS One
; 3(10): e3394, 2008.
Artigo
em Inglês
| MEDLINE | ID: mdl-18852892
19.
Phosphorylation at Ser-129 but not the phosphomimics S129E/D inhibits the fibrillation of alpha-synuclein.
J Biol Chem
; 283(24): 16895-905, 2008 Jun 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-18343814
20.
Hydrogen peroxide is generated during the very early stages of aggregation of the amyloid peptides implicated in Alzheimer disease and familial British dementia.
J Biol Chem
; 280(43): 35789-92, 2005 Oct 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-16141213