Detalhe da pesquisa
1.
Bench to bedside: The ambitious goal of transducing medicinal chemistry from the lab to the clinic.
Bioorg Med Chem Lett
; 69: 128787, 2022 08 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-35569688
2.
Selective Ligands for Non-Canonical DNA Structures: Do They Have a Future in Medicinal Chemistry?
Int J Mol Sci
; 23(19)2022 Oct 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-36233283
3.
Targeting Canine KIT Promoter by Candidate DNA G-Quadruplex Ligands.
J Pharmacol Exp Ther
; 367(3): 461-472, 2018 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-30275152
4.
Highly Improved Electrospray Ionization-Mass Spectrometry Detection of G-Quadruplex-Folded Oligonucleotides and Their Complexes with Small Molecules.
Anal Chem
; 89(17): 8632-8637, 2017 09 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-28787153
5.
Virtual Cross-Linking of the Active Nemorubicin Metabolite PNU-159682 to Double-Stranded DNA.
Chem Res Toxicol
; 30(2): 614-624, 2017 02 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-28068470
6.
G-quadruplexes in human promoters: A challenge for therapeutic applications.
Biochim Biophys Acta Gen Subj
; 1861(5 Pt B): 1399-1413, 2017 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-28025083
7.
The cellular protein nucleolin preferentially binds long-looped G-quadruplex nucleic acids.
Biochim Biophys Acta Gen Subj
; 1861(5 Pt B): 1371-1381, 2017 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-27913192
8.
Clerocidin-mediated DNA footprinting discriminates among different G-quadruplex conformations and detects tetraplex folding in a duplex environment.
Biochim Biophys Acta
; 1830(10): 4660-8, 2013 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-23747297
9.
Novel ametantrone-amsacrine related hybrids as topoisomerase IIß poisons and cytotoxic agents.
Arch Pharm (Weinheim)
; 347(10): 728-37, 2014 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-25042690
10.
Targeting loop adenines in G-quadruplex by a selective oxirane.
Chemistry
; 19(1): 78-81, 2013 Jan 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-23212868
11.
Inhibitory effects of glycosaminoglycans on basal and stimulated transforming growth factor-ß1 expression in mesangial cells: biochemical and structural considerations.
Glycobiology
; 21(8): 1029-37, 2011 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-21493663
12.
Tuning G-quadruplex vs double-stranded DNA recognition in regioisomeric lysyl-peptidyl-anthraquinone conjugates.
Bioconjug Chem
; 22(10): 2126-35, 2011 Oct 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-21905741
13.
Quinone methide generation via photoinduced electron transfer.
J Org Chem
; 76(9): 3096-106, 2011 May 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-21425810
14.
In front of and behind the replication fork: bacterial type IIA topoisomerases.
Cell Mol Life Sci
; 67(12): 2001-24, 2010 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-20165898
15.
Effects of magnesium and related divalent metal ions in topoisomerase structure and function.
Nucleic Acids Res
; 37(3): 702-11, 2009 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-19188255
16.
Photogeneration and reactivity of naphthoquinone methides as purine selective DNA alkylating agents.
J Am Chem Soc
; 132(41): 14625-37, 2010 Oct 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-20863115
17.
The 6-aminoquinolone WC5 inhibits human cytomegalovirus replication at an early stage by interfering with the transactivating activity of viral immediate-early 2 protein.
Antimicrob Agents Chemother
; 54(5): 1930-40, 2010 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-20194695
18.
Simocyclinone D8 turns on against Gram-negative bacteria in a clinical setting.
Bioorg Med Chem Lett
; 20(3): 1202-4, 2010 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20022496
19.
Clerocidin selectively modifies the gyrase-DNA gate to induce irreversible and reversible DNA damage.
Nucleic Acids Res
; 36(17): 5516-29, 2008 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-18723572
20.
Quinone methides tethered to naphthalene diimides as selective G-quadruplex alkylating agents.
J Am Chem Soc
; 131(36): 13132-41, 2009 Sep 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-19694465