RESUMO
BACKGROUND: Co-circulation of multiple dengue virus serotypes has been reported from many parts of the world including India, however concurrent infection with more than one serotype of dengue viruses in the same individual is rarely documented. An outbreak of dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS) occurred in and around Delhi in 2006. This is the first report from India with high percentage of concurrent infections with different dengue virus serotypes circulating during one outbreak. RESULTS: Acute phase sera from patients were tested for the presence of dengue virus RNA by RT-PCR assay. Of the 69 samples tested for dengue virus RNA, 48 (69.5%) were found to be positive. All the four dengue virus serotypes were found to be co-circulating in this outbreak with DENV-3 being the predominant serotype. In addition in 9 of 48 (19%) dengue virus positive samples, concurrent infection with more than one dengue virus serotype were identified. CONCLUSION: This is the first report in which concurrent infections with different dengue virus serotypes is being reported during an outbreak from India. Delhi is now truly hyperendemic for dengue.
Assuntos
Vírus da Dengue/classificação , Surtos de Doenças , RNA Viral/genética , Dengue Grave/epidemiologia , Adolescente , Adulto , Criança , Pré-Escolar , Vírus da Dengue/genética , Vírus da Dengue/isolamento & purificação , Feminino , Humanos , Índia/epidemiologia , Lactente , Recém-Nascido , Masculino , Reação em Cadeia da Polimerase Via Transcriptase Reversa , Sorotipagem , Dengue Grave/virologiaRESUMO
BACKGROUND & OBJECTIVE: Ureaplasma urealyticum has been implicated in various neonatal morbidities in preterm infants. Its association with chronic lung disease (CLD) remains controversial. The aim of this prospective study was to investigate colonization of U. urealyticum in preterm infants (with gestational age <34 wk) and to evaluate the relationship between U. urealyticum colonization and neonatal morbidity including CLD. METHODS: U. urealyticum was cultured from nasopharyngeal or endotracheal aspirates collected within 24 h of birth from infant Assuntos
Nasofaringe/microbiologia
, Traqueia/microbiologia
, Ureaplasma urealyticum/isolamento & purificação
, Feminino
, Humanos
, Recém-Nascido
, Recém-Nascido Prematuro
, Estudos Longitudinais
, Masculino
, Reação em Cadeia da Polimerase
, Estudos Prospectivos
RESUMO
Population explosion, frequent travel and urbanization have led to certain changes in the environment, which are conducive for the survival of multiple pathogens and their transmission vehicle in the same niche. Therefore, there are more chances of acquiring multiple infections at the same time with overlapping clinical manifestations. We would like to share a case having concurrent infection with four different agents.
Assuntos
Dengue/diagnóstico , Hepatite E/diagnóstico , Leptospirose/diagnóstico , Malária Vivax/diagnóstico , Adulto , Animais , Anticorpos Antibacterianos/sangue , Anticorpos Antivirais/sangue , Sangue/parasitologia , Dengue/virologia , Feminino , Anticorpos Anti-Hepatite/sangue , Hepatite E/virologia , Humanos , Imunoglobulina M/sangue , Leptospirose/microbiologia , Malária Vivax/parasitologia , Plasmodium vivax/isolamento & purificaçãoRESUMO
A case of mixed infection due to leptospira, dengue and hepatitis E is reported. Similar clinical presentation and simultaneous transmission of these diseases during rainy season can cause substantial misdiagnosis. Serological tests play a mainstay in diagnosis. Early detection by appropriate serological tests and institution of therapy is crucial and life saving.