Detalhe da pesquisa
1.
WNK kinases sense molecular crowding and rescue cell volume via phase separation.
Cell
; 185(24): 4488-4506.e20, 2022 11 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-36318922
2.
Nuclear-Import Receptors Reverse Aberrant Phase Transitions of RNA-Binding Proteins with Prion-like Domains.
Cell
; 173(3): 677-692.e20, 2018 04 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-29677512
3.
NgR1 binding to reovirus reveals an unusual bivalent interaction and a new viral attachment protein.
Proc Natl Acad Sci U S A
; 120(24): e2219404120, 2023 06 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-37276413
4.
Drosha-dependent microRNAs modulate FUS-mediated neurodegeneration in vivo.
Nucleic Acids Res
; 51(20): 11258-11276, 2023 11 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-37791873
5.
SMN regulates GEMIN5 expression and acts as a modifier of GEMIN5-mediated neurodegeneration.
Acta Neuropathol
; 146(3): 477-498, 2023 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-37369805
6.
Further delineation of GEMIN4 related neurodevelopmental disorder with microcephaly, cataract, and renal abnormalities syndrome.
Am J Med Genet A
; 188(10): 2932-2940, 2022 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-35861185
7.
Insulin-like growth factor 1 signaling in motor neuron and polyglutamine diseases: From molecular pathogenesis to therapeutic perspectives.
Front Neuroendocrinol
; 57: 100821, 2020 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-32006533
8.
DDX17 is involved in DNA damage repair and modifies FUS toxicity in an RGG-domain dependent manner.
Acta Neuropathol
; 142(3): 515-536, 2021 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-34061233
9.
Inactivation of Hippo and cJun-N-terminal Kinase (JNK) signaling mitigate FUS mediated neurodegeneration in vivo.
Neurobiol Dis
; 140: 104837, 2020 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-32199908
10.
Traumatic injury induces stress granule formation and enhances motor dysfunctions in ALS/FTD models.
Hum Mol Genet
; 27(8): 1366-1381, 2018 04 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-29432563
11.
Mutation-dependent aggregation and toxicity in a Drosophila model for UBQLN2-associated ALS.
Hum Mol Genet
; 27(2): 322-337, 2018 01 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-29161404
12.
Nuclear localized C9orf72-associated arginine-containing dipeptides exhibit age-dependent toxicity in C. elegans.
Hum Mol Genet
; 26(24): 4916-4928, 2017 12 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-29036691
13.
FUS pathology in ALS is linked to alterations in multiple ALS-associated proteins and rescued by drugs stimulating autophagy.
Acta Neuropathol
; 138(1): 67-84, 2019 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-30937520
14.
The chaperone HSPB8 reduces the accumulation of truncated TDP-43 species in cells and protects against TDP-43-mediated toxicity.
Hum Mol Genet
; 25(18): 3908-3924, 2016 09 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27466192
15.
Pur-alpha regulates cytoplasmic stress granule dynamics and ameliorates FUS toxicity.
Acta Neuropathol
; 131(4): 605-20, 2016 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-26728149
16.
RNA-binding ability of FUS regulates neurodegeneration, cytoplasmic mislocalization and incorporation into stress granules associated with FUS carrying ALS-linked mutations.
Hum Mol Genet
; 22(6): 1193-205, 2013 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23257289
17.
Impairment of the mitochondrial one-carbon metabolism enzyme SHMT2 causes a novel brain and heart developmental syndrome.
Acta Neuropathol
; 140(6): 971-975, 2020 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-33015733
18.
Defects in synapse structure and function precede motor neuron degeneration in Drosophila models of FUS-related ALS.
J Neurosci
; 33(50): 19590-8, 2013 Dec 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-24336723
19.
Human disease models in Drosophila melanogaster and the role of the fly in therapeutic drug discovery.
Pharmacol Rev
; 63(2): 411-36, 2011 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-21415126
20.
HuD (ELAVL4) gain-of-function impairs neuromuscular junctions and induces apoptosis in in vitro and in vivo models of amyotrophic lateral sclerosis.
bioRxiv
; 2024 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-38464028