Detalhe da pesquisa
1.
Loss of TREM2 rescues hyperactivation of microglia, but not lysosomal deficits and neurotoxicity in models of progranulin deficiency.
EMBO J
; 41(4): e109108, 2022 02 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-35019161
2.
Membrane lipid remodeling modulates γ-secretase processivity.
J Biol Chem
; 299(4): 103027, 2023 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-36805335
3.
Efficient introduction of specific homozygous and heterozygous mutations using CRISPR/Cas9.
Nature
; 533(7601): 125-9, 2016 May 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-27120160
4.
Immunophilin FKBP52 induces Tau-P301L filamentous assembly in vitro and modulates its activity in a model of tauopathy.
Proc Natl Acad Sci U S A
; 111(12): 4584-9, 2014 Mar 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-24623856
5.
A multi-looping chromatin signature predicts dysregulated gene expression in neurons with familial Alzheimer's disease mutations.
bioRxiv
; 2024 Feb 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-38463966
6.
Proteomics of mouse brain endothelium uncovers dysregulation of vesicular transport pathways during aging.
Nat Aging
; 4(4): 595-612, 2024 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-38519806
7.
Peripheral expression of brain-penetrant progranulin rescues pathologies in mouse models of frontotemporal lobar degeneration.
Sci Transl Med
; 16(750): eadj7308, 2024 Jun 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-38838131
8.
In vivo imaging of disease-related mitochondrial dynamics in a vertebrate model system.
J Neurosci
; 32(46): 16203-12, 2012 Nov 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-23152604
9.
Reproducible and scalable differentiation of highly pure cortical neurons from human induced pluripotent stem cells.
STAR Protoc
; 4(2): 102266, 2023 May 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-37148244
10.
Cell type-specific loops linked to RNA polymerase II elongation in human neural differentiation.
bioRxiv
; 2023 Dec 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-38106199
11.
A MICROGLIAL ACTIVITY STATE BIOMARKER PANEL DIFFERENTIATES FTD-GRANULIN AND ALZHEIMER'S DISEASE PATIENTS FROM CONTROLS.
bioRxiv
; 2023 Jun 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-37398209
12.
A microglial activity state biomarker panel differentiates FTD-granulin and Alzheimer's disease patients from controls.
Mol Neurodegener
; 18(1): 70, 2023 09 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-37775827
13.
Single-cell transcriptomic atlas-guided development of CAR-T cells for the treatment of acute myeloid leukemia.
Nat Biotechnol
; 41(11): 1618-1632, 2023 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-36914885
14.
TPC2 rescues lysosomal storage in mucolipidosis type IV, Niemann-Pick type C1, and Batten disease.
EMBO Mol Med
; 14(9): e15377, 2022 09 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-35929194
15.
A reference human induced pluripotent stem cell line for large-scale collaborative studies.
Cell Stem Cell
; 29(12): 1685-1702.e22, 2022 12 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36459969
16.
Simple and reliable detection of CRISPR-induced on-target effects by qgPCR and SNP genotyping.
Nat Protoc
; 16(3): 1714-1739, 2021 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-33597771
17.
Repurposing of tamoxifen ameliorates CLN3 and CLN7 disease phenotype.
EMBO Mol Med
; 13(10): e13742, 2021 10 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-34411438
18.
Methylene blue fails to inhibit Tau and polyglutamine protein dependent toxicity in zebrafish.
Neurobiol Dis
; 39(3): 265-71, 2010 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-20381619
19.
Transgenic zebrafish as a novel animal model to study tauopathies and other neurodegenerative disorders in vivo.
Neurodegener Dis
; 7(1-3): 99-102, 2010.
Artigo
em Inglês
| MEDLINE | ID: mdl-20173336
20.
Neurodegeneration in a dish: advancing human stem-cell-based models of Alzheimer's disease.
Curr Opin Neurobiol
; 61: 96-104, 2020 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-32112992