Recyclable & highly porous organo-aerogel adsorbents from biowaste for organic contaminants' removal.

Selective aerogel has become an attractive adsorbent for removing oil and organic contaminants due to its low density and excellent adsorption capacity. However, aerogels usually use non-sustainable or expensive nanomaterials and require complicated fabrication processes. Herein, using low-cost lignin reclaimed from the biorefinery waste stream as the starting material, we fabricated a highly porous, mechanically strong, and stable aerogel via a simple and one-step method under mild conditions. This aerogel exhibits a controllable micropore structure and achieves quick and efficient adsorption for oil (435% g/g), as well as toxic solvents such as THF (365% g/g). The selective and stable adsorbent can be reused multiple times and the oil adsorption capacity after 5 cycles remained at 89%. This highly efficient, mechanically strong, stable, and regenerable aerogel is a potential candidate for multiple applications such as cleaning up organic contaminants, oil remediation, and oil/water separation. Meanwhile, it also employs a "waste-treat-waste" concept by adding extra value to the biorefinery process for high-efficiency circular bioeconomy.

A novel combination therapy for multidrug resistant pathogens using chitosan nanoparticles loaded with ß-lactam antibiotics and ß-lactamase inhibitors.

Antimicrobial resistance is one of the greatest global threats. Particularly, multidrug resistant extended-spectrum ß-lactamase (ESBL)-producing pathogens confer resistance to many commonly used medically important antibiotics, especially beta-lactam antibiotics. Here, we developed an innovative combination approach to therapy for multidrug resistant pathogens by encapsulating cephalosporin antibiotics and ß-lactamase inhibitors with chitosan nanoparticles (CNAIs). The four combinations of CNAIs including two cephalosporin antibiotics (cefotaxime and ceftiofur) with two ß-lactamase inhibitors (tazobactam and clavulanate) were engineered as water-oil-water emulsions. Four combinations of CNAIs showed efficient antimicrobial activity against multidrug resistant ESBL-producing Enterobacteriaceae. The CNAIs showed enhanced antimicrobial activity compared to naïve chitosan nanoparticles and to the combination of cephalosporin antibiotics and ß-lactamase inhibitors. Furthermore, CNAIs attached on the bacterial surface changed the permeability to the outer membrane, resulting in cell damage that leads to cell death. Taken together, CNAIs have provided promising potential for treatment of diseases caused by critically important ESBL-producing multidrug resistant pathogens.