Detalhe da pesquisa
1.
Humanized Mouse Model of HIV-1 Latency with Enrichment of Latent Virus in PD-1+ and TIGIT+ CD4 T Cells.
J Virol
; 93(10)2019 05 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-30842333
2.
Non-viral Delivery of Zinc Finger Nuclease mRNA Enables Highly Efficient In Vivo Genome Editing of Multiple Therapeutic Gene Targets.
Mol Ther
; 27(4): 866-877, 2019 04 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-30902585
3.
Improved specificity of TALE-based genome editing using an expanded RVD repertoire.
Nat Methods
; 12(5): 465-71, 2015 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-25799440
4.
Functional footprinting of regulatory DNA.
Nat Methods
; 12(10): 927-30, 2015 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-26322838
5.
In vivo genome editing of the albumin locus as a platform for protein replacement therapy.
Blood
; 126(15): 1777-84, 2015 Oct 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-26297739
6.
Correction of the sickle cell disease mutation in human hematopoietic stem/progenitor cells.
Blood
; 125(17): 2597-604, 2015 Apr 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-25733580
7.
In vivo genome editing restores haemostasis in a mouse model of haemophilia.
Nature
; 475(7355): 217-21, 2011 Jun 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-21706032
8.
Targeted gene correction of α1-antitrypsin deficiency in induced pluripotent stem cells.
Nature
; 478(7369): 391-4, 2011 Oct 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-21993621
9.
LRRK2 mutations cause mitochondrial DNA damage in iPSC-derived neural cells from Parkinson's disease patients: reversal by gene correction.
Neurobiol Dis
; 62: 381-6, 2014 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-24148854
10.
Efficient targeted gene disruption in the soma and germ line of the frog Xenopus tropicalis using engineered zinc-finger nucleases.
Proc Natl Acad Sci U S A
; 108(17): 7052-7, 2011 Apr 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-21471457
11.
Functional genomics, proteomics, and regulatory DNA analysis in isogenic settings using zinc finger nuclease-driven transgenesis into a safe harbor locus in the human genome.
Genome Res
; 20(8): 1133-42, 2010 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-20508142
12.
An engineered zinc finger protein activator of the endogenous glial cell line-derived neurotrophic factor gene provides functional neuroprotection in a rat model of Parkinson's disease.
J Neurosci
; 30(49): 16469-74, 2010 Dec 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-21147986
13.
Enhancing gene editing specificity by attenuating DNA cleavage kinetics.
Nat Biotechnol
; 37(8): 945-952, 2019 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-31359006
14.
Diversifying the structure of zinc finger nucleases for high-precision genome editing.
Nat Commun
; 10(1): 1133, 2019 03 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-30850604
15.
Allele-selective transcriptional repression of mutant HTT for the treatment of Huntington's disease.
Nat Med
; 25(7): 1131-1142, 2019 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-31263285
16.
Genome Editing in Neuroepithelial Stem Cells to Generate Human Neurons with High Adenosine-Releasing Capacity.
Stem Cells Transl Med
; 7(6): 477-486, 2018 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-29589874
17.
Enhanced catalytic efficiency of aminoglycoside phosphotransferase (3')-IIa achieved through protein fragmentation and reassembly.
J Mol Biol
; 353(1): 26-37, 2005 Oct 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-16168439
18.
Mammalian interspecies substitution of immune modulatory alleles by genome editing.
Sci Rep
; 6: 21645, 2016 Feb 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-26898342
19.
Gene Correction of iPSCs from a Wiskott-Aldrich Syndrome Patient Normalizes the Lymphoid Developmental and Functional Defects.
Stem Cell Reports
; 7(2): 139-48, 2016 08 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-27396937
20.
Targeted gene addition in human CD34(+) hematopoietic cells for correction of X-linked chronic granulomatous disease.
Nat Biotechnol
; 34(4): 424-9, 2016 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-26950749