Detalhe da pesquisa
1.
XBP1 promotes NRASG12D pre-B acute lymphoblastic leukaemia through IL-7 receptor signalling and provides a therapeutic vulnerability for oncogenic RAS.
J Cell Mol Med
; 27(21): 3363-3377, 2023 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-37753803
2.
Targeting of BCR-ABL1 and IRE1α induces synthetic lethality in Philadelphia-positive acute lymphoblastic leukemia.
Carcinogenesis
; 42(2): 272-284, 2021 02 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-32915195
3.
Publisher Correction: Pharmacological targeting of the unfolded protein response for disease intervention.
Nat Chem Biol
; 15(11): 1129, 2019 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-31439938
4.
Pharmacological targeting of the unfolded protein response for disease intervention.
Nat Chem Biol
; 15(8): 764-775, 2019 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-31320759
5.
Inhibition of IRE1α RNase activity sensitizes patient-derived acute myeloid leukaemia cells to proteasome inhibitors.
J Cell Mol Med
; 26(16): 4629-4633, 2022 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-35822520
6.
Blockade of XBP1 splicing by inhibition of IRE1α is a promising therapeutic option in multiple myeloma.
Blood
; 119(24): 5772-81, 2012 Jun 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-22538852
7.
Correction: Dastghaib et al. Simvastatin Induces Unfolded Protein Response and Enhances Temozolomide-Induced Cell Death in Glioblastoma Cells. Cells 2020, 9, 2339.
Cells
; 13(8)2024 Apr 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-38667338
8.
Potent and selective inhibitors of the inositol-requiring enzyme 1 endoribonuclease.
J Biol Chem
; 286(14): 12743-55, 2011 Apr 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-21303903
9.
The IRE1 and PERK arms of the unfolded protein response promote survival of rhabdomyosarcoma cells.
Cancer Lett
; 490: 76-88, 2020 10 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-32679165
10.
Simvastatin Induces Unfolded Protein Response and Enhances Temozolomide-Induced Cell Death in Glioblastoma Cells.
Cells
; 9(11)2020 10 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-33105603
11.
Correction: Inhibition of IRE1α RNase activity reduces NLRP3 inflammasome assembly and processing of pro-IL1ß.
Cell Death Dis
; 11(1): 12, 2020 Jan 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-31907350
12.
Local intracerebral inhibition of IRE1 by MKC8866 sensitizes glioblastoma to irradiation/chemotherapy in vivo.
Cancer Lett
; 494: 73-83, 2020 12 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32882336
13.
Stress chaperone GRP78/BiP confers chemoresistance to tumor-associated endothelial cells.
Mol Cancer Res
; 6(8): 1268-75, 2008 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-18708359
14.
Inhibition of IRE1α RNase activity reduces NLRP3 inflammasome assembly and processing of pro-IL1ß.
Cell Death Dis
; 10(9): 622, 2019 08 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-31417078
15.
IRE1α-XBP1s pathway promotes prostate cancer by activating c-MYC signaling.
Nat Commun
; 10(1): 323, 2019 01 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-30679434
16.
Infliction of proteotoxic stresses by impairment of the unfolded protein response or proteasomal inhibition as a therapeutic strategy for mast cell leukemia.
Oncotarget
; 9(3): 2984-3000, 2018 Jan 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-29423023
17.
Inhibition of IRE1 RNase activity modulates the tumor cell secretome and enhances response to chemotherapy.
Nat Commun
; 9(1): 3267, 2018 08 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-30111846
18.
Dual IRE1 RNase functions dictate glioblastoma development.
EMBO Mol Med
; 15(2): e16731, 2023 Feb 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-36752056
19.
Low-Protein Diet Induces IRE1α-Dependent Anticancer Immunosurveillance.
Cell Metab
; 27(4): 828-842.e7, 2018 04 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-29551590
20.
Dual IRE1 RNase functions dictate glioblastoma development.
EMBO Mol Med
; 10(3)2018 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-29311133