Detalhe da pesquisa
1.
7-Year (2015-21) longitudinal surveillance of lefamulin in vitro activity against bacterial pathogens collected worldwide from patients with respiratory tract infections including pneumonia and characterization of resistance mechanisms.
J Antimicrob Chemother
; 79(2): 360-369, 2024 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-38113528
2.
In Vivo Immune-Modulatory Activity of Lefamulin in an Influenza Virus A (H1N1) Infection Model in Mice.
Int J Mol Sci
; 25(10)2024 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-38791439
3.
Phenotypic and genotypic antimicrobial susceptibility patterns of the emerging human respiratory pathogen Mycoplasma amphoriforme isolated from the UK and Denmark.
J Antimicrob Chemother
; 77(11): 3126-3129, 2022 10 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-36048620
4.
Lefamulin efficacy and safety in a pooled phase 3 clinical trial population with community-acquired bacterial pneumonia and common clinical comorbidities.
BMC Pulm Med
; 21(1): 154, 2021 May 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-33964925
5.
Efficacy and Safety of Intravenous-to-oral Lefamulin, a Pleuromutilin Antibiotic, for the Treatment of Community-acquired Bacterial Pneumonia: The Phase III Lefamulin Evaluation Against Pneumonia (LEAP 1) Trial.
Clin Infect Dis
; 69(11): 1856-1867, 2019 11 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-30722059
6.
Antibacterial Activity of Lefamulin against Pathogens Most Commonly Causing Community-Acquired Bacterial Pneumonia: SENTRY Antimicrobial Surveillance Program (2015-2016).
Antimicrob Agents Chemother
; 63(4)2019 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-30670415
7.
Low Prevalence of Gram-Positive Isolates Showing Elevated Lefamulin MIC Results during the SENTRY Surveillance Program for 2015-2016 and Characterization of Resistance Mechanisms.
Antimicrob Agents Chemother
; 63(4)2019 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-30670418
8.
Pharmacokinetics/pharmacodynamics of lefamulin in a neutropenic murine pneumonia model with Staphylococcus aureus and Streptococcus pneumoniae.
J Antimicrob Chemother
; 74(Suppl 3): iii11-iii18, 2019 04 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30949707
9.
Oral Lefamulin vs Moxifloxacin for Early Clinical Response Among Adults With Community-Acquired Bacterial Pneumonia: The LEAP 2 Randomized Clinical Trial.
JAMA
; 322(17): 1661-1671, 2019 Nov 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-31560372
10.
In Vitro Activity of Lefamulin against Sexually Transmitted Bacterial Pathogens.
Antimicrob Agents Chemother
; 62(5)2018 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-29530863
11.
Structural insights into species-specific features of the ribosome from the pathogen Staphylococcus aureus.
Proc Natl Acad Sci U S A
; 112(43): E5805-14, 2015 Oct 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-26464510
12.
In Vitro Activity of the Novel Pleuromutilin Lefamulin (BC-3781) and Effect of Efflux Pump Inactivation on Multidrug-Resistant and Extensively Drug-Resistant Neisseria gonorrhoeae.
Antimicrob Agents Chemother
; 61(11)2017 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-28893785
13.
In Vitro Activities of Lefamulin and Other Antimicrobial Agents against Macrolide-Susceptible and Macrolide-Resistant Mycoplasma pneumoniae from the United States, Europe, and China.
Antimicrob Agents Chemother
; 61(2)2017 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-27855075
14.
In Vitro Activity of Lefamulin Tested against Streptococcus pneumoniae with Defined Serotypes, Including Multidrug-Resistant Isolates Causing Lower Respiratory Tract Infections in the United States.
Antimicrob Agents Chemother
; 60(7): 4407-11, 2016 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-27161634
15.
Erratum to: Efficacy and Safety of Intravenous-to-oral Lefamulin, a Pleuromutilin Antibiotic, for the Treatment of Community-acquired Bacterial Pneumonia: The Phase III Lefamulin Evaluation Against Pneumonia (LEAP 1) Trial.
Clin Infect Dis
; 70(11): 2459, 2020 05 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-31626688
16.
Antimicrobial activity of the pleuromutilin antibiotic BC-3781 against bacterial pathogens isolated in the SENTRY antimicrobial surveillance program in 2010.
Antimicrob Agents Chemother
; 57(9): 4489-95, 2013 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-23836172
17.
Antimicrobial activity of the investigational pleuromutilin compound BC-3781 tested against Gram-positive organisms commonly associated with acute bacterial skin and skin structure infections.
Antimicrob Agents Chemother
; 56(3): 1619-23, 2012 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-22232289
18.
Disk diffusion and MIC quality control ranges for BC-3205 and BC-3781, two novel pleuromutilin antibiotics.
J Clin Microbiol
; 50(10): 3361-4, 2012 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-22814462
19.
Antimicrobial activity of the novel pleuromutilin antibiotic BC-3781 against organisms responsible for community-acquired respiratory tract infections (CARTIs).
J Antimicrob Chemother
; 67(5): 1170-5, 2012 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-22287234
20.
A plain language summary of how lefamulin alone can be used to treat pneumonia caught outside of the hospital due to common bacterial causes, including drug-resistant bacteria.
Future Microbiol
; 17: 397-410, 2022 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-35285291