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Inflamm Res ; 72(10-11): 1933-1940, 2023 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-36416944

RESUMO

OBJECTIVE AND DESIGN: The heterogeneity of response to SARS-CoV-2 infection is directly linked to the individual genetic background. Genetic variants of inflammasome-related genes have been pointed as risk factors for several inflammatory sterile and infectious disease. In the group of inflammasome receptors, NLRP1 stands out as a good novel candidate as severity factor for COVID-19 disease. METHODS: To address this question, we performed an association study of NLRP1, DPP9, CARD8, IL1B, and IL18 single nucleotide variants (SNVs) in a cohort of 945 COVID-19 patients. RESULTS: The NLRP1 p.Leu155His in the linker region, target of viral protease, was significantly associated to COVID-19 severity, which could contribute to the excessive cytokine release reported in severe cases. CONCLUSION: Inflammasome genetic background contributes to individual response to SARS-CoV-2.


Assuntos
COVID-19 , Inflamassomos , Humanos , Inflamassomos/genética , Inflamassomos/metabolismo , Proteínas Adaptadoras de Transdução de Sinal/genética , Proteínas Adaptadoras de Transdução de Sinal/metabolismo , COVID-19/genética , Proteínas NLR/genética , SARS-CoV-2/metabolismo , Proteínas de Neoplasias/genética , Proteínas Adaptadoras de Sinalização CARD/genética
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