Cerebral palsy and bisphosphonates - and what can be learned from other types of secondary osteoporosis in children: A scoping review.

AIM: We aimed to improve bone health management of children with cerebral palsy (CP) by reviewing studies investigating bisphosphonate therapy in children with CP and other types of secondary osteoporosis. METHODS: We included trials on bisphosphonate treatment reporting any direct bone measurement or fracture outcome. All studies of patients with CP were included. We also included all controlled trials of children with secondary bone fragility as well as observational studies with ≥20 participants or at least 3 years of follow-up. Studies were assessed according to PRISMA guidelines using the RoB2-tool and the Newcastle-Ottawa Scale. RESULTS: We reviewed 1104 studies and found 37 eligible. Some studies were sufficiently homogeneous to include in a meta-analysis, and we found a 1-year effect on lumbar spine bone mineral density (BMD) Z-score of +0.65 after oral and + 1.21 after intravenous bisphosphonates in children with secondary osteoporosis. Further, data on adverse events and post-treatment follow-up were reviewed. Limitations were heterogeneity and small size of the included studies. CONCLUSION: Meta-analysis consistently showed significant BMD increases with bisphosphonates in children with secondary osteoporosis. Direct evidence of the effect of bisphosphonates on reducing fractures is lacking. We found no reports of long-term adverse events yet longer studies are needed.

Low rate of clinically important avascular necrosis of the femoral head after Ludloff's procedure.

INTRODUCTION: Ludloff's procedure for open reduction of congenital dislocation of the hip (CDH) is recommended for its minimal tissue damage, but is criticised for the risk of late avascular necrosis (AVN) of the femoral head. The aim of present study was primarily to assess the risk of late AVN of the femoral head and secondly the range of motion (ROM) of the hip and the quality of life in children following Ludloff's procedure. METHODS AND MATERIALS: 13 hips in 11 children after Ludloff's procedure due to CDH were included retrospectively from 1997 to 2005 at Aarhus University Hospital. Radiographs were evaluated for the presence of AVN of the femoral head and classified according to the Bucholz and Ogden classification, with type 2-4 having clinical relevance. A clinical examination included range of motion (ROM) and leg length discrepancy (LLD) measurements. The HAGOS hip questionnaire evaluated activity, participation and quality of life. RESULTS: No severe type 3-4 AVN was observed. 2 type 2 and 5 type 1 were observed. AVN was observed in 7 of the 13 operated hips (54%). An 8.6° difference in flexion for unilaterally treated hips was observed (p<0.02). 8 of 11 patients had minor LLD (range 0.5-2 cm). CONCLUSIONS: Only minor AVN of clinical importance was seen after Ludloff's procedure.

Intra- and interrater agreement of pressure pain thresholds in children with orthopedic disorders.

PURPOSE: Pressure algometry is widely used to obtain measures of mechanical pain sensitivity in adults, both in experimental and clinical pain conditions. Only very few studies describe the use of pressure algometry in children. The purpose of this study was to produce reference values of pressure pain thresholds and to determine the intra- and interrater agreement, in order to introduce pressure algometry as a standardized method for the assessment of pain thresholds in children with orthopedic disorders. METHODS: Pressure pain thresholds were determined at the leg and at the thenar in 50 children aged 4-12 years. All were scheduled for physical examination at the outpatient Orthopedic Clinic at Aarhus University Hospital, Denmark, because of various orthopedic disorders such as clubfoot and Baker's cyst. Pressure pain thresholds were determined by two different raters: 20 children were examined twice by rater 1 (intrarater agreement), and another 20 children were examined by both rater 1 and rater 2 (interrater agreement). An additional ten children were examined once by rater 1 to increase the number of children used to determine the reference values. RESULTS: The pressure pain threshold was 183.1 kPa (mean, SD: 90.7) at the leg and 179.1 kPa (mean, SD: 97.4 kPa) at the thenar (n = 50). Pressure pain thresholds were similar in boys (n = 27) and girls (n = 23). Also, pressure pain thresholds were not affected by age. Bland-Altman plots showed excellent intrarater agreement and satisfactory interrater agreement. CONCLUSION: Pressure algometry has excellent intrarater agreement and satisfactory interrater agreement. Pressure algometry was well-tolerated even by very young children. The method deserves more widespread use both in clinical and experimental settings.