Detalhe da pesquisa
1.
Tau and Amyloid ß Protein in Patient-Derived Aqueous Brain Extracts Act Concomitantly to Disrupt Long-Term Potentiation in Vivo.
J Neurosci
; 43(32): 5870-5879, 2023 08 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-37491315
2.
P2X7R influences tau aggregate burden in human tauopathies and shows distinct signalling in microglia and astrocytes.
Brain Behav Immun
; 114: 414-429, 2023 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-37716378
3.
PrP is a central player in toxicity mediated by soluble aggregates of neurodegeneration-causing proteins.
Acta Neuropathol
; 139(3): 503-526, 2020 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-31853635
4.
Cellular Prion Protein Mediates the Disruption of Hippocampal Synaptic Plasticity by Soluble Tau In Vivo.
J Neurosci
; 38(50): 10595-10606, 2018 12 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-30355631
5.
Soluble tau aggregates inhibit synaptic long-term depression and amyloid ß-facilitated LTD in vivo.
Neurobiol Dis
; 127: 582-590, 2019 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-30910746
6.
Preclinical development of a high affinity α-synuclein antibody, MEDI1341, that can enter the brain, sequester extracellular α-synuclein and attenuate α-synuclein spreading in vivo.
Neurobiol Dis
; 132: 104582, 2019 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-31445162
7.
Loss of c-Jun N-terminal kinase-interacting protein-1 does not affect axonal transport of the amyloid precursor protein or Aß production.
Hum Mol Genet
; 22(22): 4646-52, 2013 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23825109
8.
Calsyntenin-1 mediates axonal transport of the amyloid precursor protein and regulates Aß production.
Hum Mol Genet
; 21(13): 2845-54, 2012 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22434822
9.
GULP1 is a novel APP-interacting protein that alters APP processing.
Biochem J
; 436(3): 631-9, 2011 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21486224
10.
X11beta rescues memory and long-term potentiation deficits in Alzheimer's disease APPswe Tg2576 mice.
Hum Mol Genet
; 18(23): 4492-500, 2009 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19744962
11.
Synaptic NMDA receptor activation stimulates alpha-secretase amyloid precursor protein processing and inhibits amyloid-beta production.
J Neurosci
; 29(14): 4442-60, 2009 Apr 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-19357271
12.
Amyloid precursor protein 695 associates with assembled NR2A- and NR2B-containing NMDA receptors to result in the enhancement of their cell surface delivery.
J Neurochem
; 111(6): 1501-13, 2009 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-19811606
13.
Increased Foxo3a Nuclear Translocation and Activity is an Early Neuronal Response to ßγ-Secretase-Mediated Processing of the Amyloid-ß Protein Precursor: Utility of an AßPP-GAL4 Reporter Assay.
J Alzheimers Dis
; 61(2): 673-688, 2018.
Artigo
em Inglês
| MEDLINE | ID: mdl-29254083
14.
Characterisation of tau in the human and rodent enteric nervous system under physiological conditions and in tauopathy.
Acta Neuropathol Commun
; 6(1): 65, 2018 07 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-30037345
15.
Membrane association and release of wild-type and pathological tau from organotypic brain slice cultures.
Cell Death Dis
; 8(3): e2671, 2017 03 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-28300838
16.
Dietary (-)-epicatechin as a potent inhibitor of ßγ-secretase amyloid precursor protein processing.
Neurobiol Aging
; 36(1): 178-87, 2015 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-25316600
17.
AMPA receptor activation promotes non-amyloidogenic amyloid precursor protein processing and suppresses neuronal amyloid-ß production.
PLoS One
; 8(10): e78155, 2013.
Artigo
em Inglês
| MEDLINE | ID: mdl-24205136
18.
Deficiency of the copper chaperone for superoxide dismutase increases amyloid-ß production.
J Alzheimers Dis
; 21(4): 1101-5, 2010.
Artigo
em Inglês
| MEDLINE | ID: mdl-20693630
19.
An X11alpha/FSBP complex represses transcription of the GSK3beta gene promoter.
Neuroreport
; 21(11): 761-6, 2010 Aug 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-20531236
20.
Expression of the neuronal adaptor protein X11alpha protects against memory dysfunction in a transgenic mouse model of Alzheimer's disease.
J Alzheimers Dis
; 20(1): 31-6, 2010.
Artigo
em Inglês
| MEDLINE | ID: mdl-20378958