1.
Bioorg Med Chem Lett
; 20(3): 857-61, 2010 Feb 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-20074949
RESUMO
SAR studies at the N(1)-position of allosteric indole-based HCV NS5B inhibitors has led to the discovery of acetamide derivatives with good cellular potency in subgenomic replicons (EC(50) <200 nM). This class of inhibitors displayed improved physicochemical properties and favorable ADME-PK profiles over previously described analogs in this class.