Pesquisa | Portal de Pesquisa da BVS Enfermagem

1.

miR-328 functions as an RNA decoy to modulate hnRNP E2 regulation of mRNA translation in leukemic blasts.

Eiring, Anna M; Harb, Jason G; Neviani, Paolo; Garton, Christopher; Oaks, Joshua J; Spizzo, Riccardo; Liu, Shujun; Schwind, Sebastian; Santhanam, Ramasamy; Hickey, Christopher J; Becker, Heiko; Chandler, Jason C; Andino, Raul; Cortes, Jorge; Hokland, Peter; Huettner, Claudia S; Bhatia, Ravi; Roy, Denis C; Liebhaber, Stephen A; Caligiuri, Michael A; Marcucci, Guido; Garzon, Ramiro; Croce, Carlo M; Calin, George A; Perrotti, Danilo.

Cell ; 140(5): 652-65, 2010 Mar 05.

Artigo em Inglês | MEDLINE | ID: mdl-20211135

2.

Somatic variants in epigenetic modifiers can predict failure of response to imatinib but not to second-generation tyrosine kinase inhibitors.

Nteliopoulos, Georgios; Bazeos, Alexandra; Claudiani, Simone; Gerrard, Gareth; Curry, Edward; Szydlo, Richard; Alikian, Mary; Foong, Hui En; Nikolakopoulou, Zacharoula; Loaiza, Sandra; Khorashad, Jamshid S; Milojkovic, Dragana; Perrotti, Danilo; Gale, Robert Peter; Foroni, Letizia; Apperley, Jane F.

Haematologica ; 104(12): 2400-2409, 2019 12.

Artigo em Inglês | MEDLINE | ID: mdl-31073075

3.

BCR-ABL1 mediated miR-150 downregulation through MYC contributed to myeloid differentiation block and drug resistance in chronic myeloid leukemia.

Srutova, Klara; Curik, Nikola; Burda, Pavel; Savvulidi, Filipp; Silvestri, Giovannino; Trotta, Rossana; Klamova, Hana; Pecherkova, Pavla; Sovova, Zofie; Koblihova, Jitka; Stopka, Tomas; Perrotti, Danilo; Polakova, Katerina Machova.

Haematologica ; 103(12): 2016-2025, 2018 12.

Artigo em Inglês | MEDLINE | ID: mdl-30049824

4.

Precision immunotherapy, mutational landscape, and emerging tools to optimize clinical outcomes in patients with classical myeloproliferative neoplasms.

Mughal, Tariq I; Lion, Thomas; Abdel-Wahab, Omar; Mesa, Ruben; Scherber, Robyn M; Perrotti, Danilo; Mauro, Michael; Verstovsek, Srdan; Saglio, Giuseppe; Van Etten, Richard A; Kralovics, Robert.

Hematol Oncol ; 36(5): 740-748, 2018 Dec.

Artigo em Inglês | MEDLINE | ID: mdl-30074634

5.

Role of altered growth factor receptor-mediated JAK2 signaling in growth and maintenance of human acute myeloid leukemia stem cells.

Cook, Amy M; Li, Liang; Ho, Yinwei; Lin, Allen; Li, Ling; Stein, Anthony; Forman, Stephen; Perrotti, Danilo; Jove, Richard; Bhatia, Ravi.

Blood ; 123(18): 2826-37, 2014 May 01.

Artigo em Inglês | MEDLINE | ID: mdl-24668492

6.

Estrogen mediated-activation of miR-191/425 cluster modulates tumorigenicity of breast cancer cells depending on estrogen receptor status.

Di Leva, Gianpiero; Piovan, Claudia; Gasparini, Pierluigi; Ngankeu, Apollinaire; Taccioli, Cristian; Briskin, Daniel; Cheung, Douglas G; Bolon, Brad; Anderlucci, Laura; Alder, Hansjuerg; Nuovo, Gerard; Li, Meng; Iorio, Marilena V; Galasso, Marco; Santhanam, Ramasamy; Ramasamy, Santhanam; Marcucci, Guido; Perrotti, Danilo; Powell, Kimerly A; Bratasz, Anna; Garofalo, Michela; Nephew, Kenneth P; Croce, Carlo M.

PLoS Genet ; 9(3): e1003311, 2013.

Artigo em Inglês | MEDLINE | ID: mdl-23505378

7.

Antagonistic activities of the immunomodulator and PP2A-activating drug FTY720 (Fingolimod, Gilenya) in Jak2-driven hematologic malignancies.

Oaks, Joshua J; Santhanam, Ramasamy; Walker, Christopher J; Roof, Steve; Harb, Jason G; Ferenchak, Greg; Eisfeld, Ann-Kathrin; Van Brocklyn, James R; Briesewitz, Roger; Saddoughi, Sahar A; Nagata, Kyosuke; Bittman, Robert; Caligiuri, Michael A; Abdel-Wahab, Omar; Levine, Ross; Arlinghaus, Ralph B; Quintas-Cardama, Alfonso; Goldman, John M; Apperley, Jane; Reid, Alistair; Milojkovic, Dragana; Ziolo, Mark T; Marcucci, Guido; Ogretmen, Besim; Neviani, Paolo; Perrotti, Danilo.

Blood ; 122(11): 1923-34, 2013 Sep 12.

Artigo em Inglês | MEDLINE | ID: mdl-23926298

8.

Preclinical and clinical efficacy of XPO1/CRM1 inhibition by the karyopherin inhibitor KPT-330 in Ph+ leukemias.

Walker, Christopher J; Oaks, Joshua J; Santhanam, Ramasamy; Neviani, Paolo; Harb, Jason G; Ferenchak, Gregory; Ellis, Justin J; Landesman, Yosef; Eisfeld, Ann-Kathrin; Gabrail, Nash Y; Smith, Carrie L; Caligiuri, Michael A; Hokland, Peter; Roy, Denis Claude; Reid, Alistair; Milojkovic, Dragana; Goldman, John M; Apperley, Jane; Garzon, Ramiro; Marcucci, Guido; Shacham, Sharon; Kauffman, Michael G; Perrotti, Danilo.

Blood ; 122(17): 3034-44, 2013 Oct 24.

Artigo em Inglês | MEDLINE | ID: mdl-23970380

9.

Lenalidomide-mediated enhanced translation of C/EBPα-p30 protein up-regulates expression of the antileukemic microRNA-181a in acute myeloid leukemia.

Hickey, Christopher J; Schwind, Sebastian; Radomska, Hanna S; Dorrance, Adrienne M; Santhanam, Ramasamy; Mishra, Anjali; Wu, Yue-Zhong; Alachkar, Houda; Maharry, Kati; Nicolet, Deedra; Mrózek, Krzysztof; Walker, Alison; Eiring, Anna M; Whitman, Susan P; Becker, Heiko; Perrotti, Danilo; Wu, Lai-Chu; Zhao, Xi; Fehniger, Todd A; Vij, Ravi; Byrd, John C; Blum, William; Lee, L James; Caligiuri, Michael A; Bloomfield, Clara D; Garzon, Ramiro; Marcucci, Guido.

Blood ; 121(1): 159-69, 2013 Jan 03.

Artigo em Inglês | MEDLINE | ID: mdl-23100311

10.

Rac guanosine triphosphatases represent integrating molecular therapeutic targets for BCR-ABL-induced myeloproliferative disease.

Thomas, Emily K; Cancelas, Jose A; Chae, Hee-Don; Cox, Adrienne D; Keller, Patricia J; Perrotti, Danilo; Neviani, Paolo; Druker, Brian J; Setchell, Kenneth D R; Zheng, Yi; Harris, Chad E; Williams, David A.

Cancer Cell ; 12(5): 467-78, 2007 Nov.

Artigo em Inglês | MEDLINE | ID: mdl-17996650

11.

miR-155 targets histone deacetylase 4 (HDAC4) and impairs transcriptional activity of B-cell lymphoma 6 (BCL6) in the Eµ-miR-155 transgenic mouse model.

Sandhu, Sukhinder K; Volinia, Stefano; Costinean, Stefan; Galasso, Marco; Neinast, Reid; Santhanam, Ramasamy; Parthun, Mark R; Perrotti, Danilo; Marcucci, Guido; Garzon, Ramiro; Croce, Carlo M.

Proc Natl Acad Sci U S A ; 109(49): 20047-52, 2012 Dec 04.

Artigo em Inglês | MEDLINE | ID: mdl-23169640

12.

MicroRNAs bind to Toll-like receptors to induce prometastatic inflammatory response.

Fabbri, Muller; Paone, Alessio; Calore, Federica; Galli, Roberta; Gaudio, Eugenio; Santhanam, Ramasamy; Lovat, Francesca; Fadda, Paolo; Mao, Charlene; Nuovo, Gerard J; Zanesi, Nicola; Crawford, Melissa; Ozer, Gulcin H; Wernicke, Dorothee; Alder, Hansjuerg; Caligiuri, Michael A; Nana-Sinkam, Patrick; Perrotti, Danilo; Croce, Carlo M.

Proc Natl Acad Sci U S A ; 109(31): E2110-6, 2012 Jul 31.

Artigo em Inglês | MEDLINE | ID: mdl-22753494

13.

Regulation of acute graft-versus-host disease by microRNA-155.

Ranganathan, Parvathi; Heaphy, Catherine E A; Costinean, Stefan; Stauffer, Nicole; Na, Caroline; Hamadani, Mehdi; Santhanam, Ramasamy; Mao, Charlene; Taylor, Patricia A; Sandhu, Sukhinder; He, Gang; Shana'ah, Arwa; Nuovo, Gerard J; Lagana, Alessandro; Cascione, Luciano; Obad, Susanna; Broom, Oliver; Kauppinen, Sakari; Byrd, John C; Caligiuri, Michael; Perrotti, Danilo; Hadley, Gregg A; Marcucci, Guido; Devine, Steven M; Blazar, Bruce R; Croce, Carlo M; Garzon, Ramiro.

Blood ; 119(20): 4786-97, 2012 May 17.

Artigo em Inglês | MEDLINE | ID: mdl-22408260

14.

Clinical and pharmacodynamic activity of bortezomib and decitabine in acute myeloid leukemia.

Blum, William; Schwind, Sebastian; Tarighat, Somayeh S; Geyer, Susan; Eisfeld, Ann-Kathrin; Whitman, Susan; Walker, Alison; Klisovic, Rebecca; Byrd, John C; Santhanam, Ramasamy; Wang, Hongyan; Curfman, John P; Devine, Steven M; Jacob, Samson; Garr, Celia; Kefauver, Cheryl; Perrotti, Danilo; Chan, Kenneth K; Bloomfield, Clara D; Caligiuri, Michael A; Grever, Michael R; Garzon, Ramiro; Marcucci, Guido.

Blood ; 119(25): 6025-31, 2012 Jun 21.

Artigo em Inglês | MEDLINE | ID: mdl-22566605

15.

Mutated beta-catenin evades a microRNA-dependent regulatory loop.

Veronese, Angelo; Visone, Rosa; Consiglio, Jessica; Acunzo, Mario; Lupini, Laura; Kim, Taewan; Ferracin, Manuela; Lovat, Francesca; Miotto, Elena; Balatti, Veronica; D'Abundo, Lucilla; Gramantieri, Laura; Bolondi, Luigi; Pekarsky, Yuri; Perrotti, Danilo; Negrini, Massimo; Croce, Carlo M.

Proc Natl Acad Sci U S A ; 108(12): 4840-5, 2011 Mar 22.

Artigo em Inglês | MEDLINE | ID: mdl-21383185

16.

Protein phosphatase 2A: a target for anticancer therapy.

Perrotti, Danilo; Neviani, Paolo.

Lancet Oncol ; 14(6): e229-38, 2013 May.

Artigo em Inglês | MEDLINE | ID: mdl-23639323

17.

The PP2A inhibitor SET regulates natural killer cell IFN-gamma production.

Trotta, Rossana; Ciarlariello, David; Dal Col, Jessica; Allard, Jeffrey; Neviani, Paolo; Santhanam, Ramasamy; Mao, Hsiaoyin; Becknell, Brian; Yu, Jianhua; Ferketich, Amy K; Thomas, Brittany; Modi, Aalok; Blaser, Bradley W; Perrotti, Danilo; Caligiuri, Michael A.

J Exp Med ; 204(10): 2397-405, 2007 Oct 01.

Artigo em Inglês | MEDLINE | ID: mdl-17875674

18.

Twisting IL-1 signaling to kill CML stem cells.

Stramucci, Lorenzo; Perrotti, Danilo.

Blood ; 128(23): 2592-2593, 2016 12 08.

Artigo em Inglês | MEDLINE | ID: mdl-27932325

19.

The PP2A inhibitor SET regulates granzyme B expression in human natural killer cells.

Trotta, Rossana; Ciarlariello, David; Dal Col, Jessica; Mao, Hsiaoyin; Chen, Li; Briercheck, Edward; Yu, Jianhua; Zhang, Jianying; Perrotti, Danilo; Caligiuri, Michael A.

Blood ; 117(8): 2378-84, 2011 Feb 24.

Artigo em Inglês | MEDLINE | ID: mdl-21156847

20.

Sphingosine kinase-1 and sphingosine 1-phosphate receptor 2 mediate Bcr-Abl1 stability and drug resistance by modulation of protein phosphatase 2A.

Salas, Arelis; Ponnusamy, Suriyan; Senkal, Can E; Meyers-Needham, Marisa; Selvam, Shanmugam Panneer; Saddoughi, Sahar A; Apohan, Elif; Sentelle, R David; Smith, Charles; Gault, Christopher R; Obeid, Lina M; El-Shewy, Hesham M; Oaks, Joshua; Santhanam, Ramasamy; Marcucci, Guido; Baran, Yusuf; Mahajan, Sandeep; Fernandes, Daniel; Stuart, Robert; Perrotti, Danilo; Ogretmen, Besim.

Blood ; 117(22): 5941-52, 2011 Jun 02.

Artigo em Inglês | MEDLINE | ID: mdl-21527515

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