Teenage status of hyperactive and nonhyperactive learning disabled boys.

Three groups of learning disabled boys--hyperactives, normoactives, and hypoactives--were studied in grade school, reevaluated at fourteen. At follow-up, all three groups remained at disadvantage to controls on academic and cognitive measures and on complex reaction time. Half the hyperactives had experienced major conflicts with authority, and over a third of hypoactives exhibited psychologically disturbing behaviors. Mental health of normoactives appeared comparable to controls.

Molecular genetic analysis of 675 group A streptococcus isolates collected in a carrier study at Lackland Air Force Base, San Antonio, Texas.

Contemporary molecular genetic analysis methods have not been used to study large samples of carriage isolates of group A Streptococcus. To determine the emm types causing asymptomatic carriage and pharyngitis in a closed population, we analyzed 675 isolates recovered from a population-based surveillance study of 10,634 recruits at Lackland Air Force Base, Texas, during 4 months in 1993-1994. Strains with emm1 and emm6 alleles accounted for only 22% of the isolates recovered from asymptomatic recruits at entrance to training. However, these 2 emm types caused 69% of the pharyngitis cases identified during training and represented 51% of the isolates recovered from the throat on exit from training. Sequence analysis of the hypervariable sic gene documented that distinct emm1 subclones disseminated in specific training groups called flights. The preferential increase in the prevalence of emm1 and emm6 isolates during the 6-week training period indicates an enhanced ability of these strains to disseminate and cause disease in this population.