Pesquisa | Portal de Pesquisa da BVS Enfermagem

1.

Mammalian life depends on two distinct pathways of DNA damage tolerance.

Buoninfante, Olimpia Alessandra; Pilzecker, Bas; Spanjaard, Aldo; de Groot, Daniël; Prekovic, Stefan; Song, Ji-Ying; Lieftink, Cor; Ayidah, Matilda; Pritchard, Colin E J; Vivié, Judith; Mcgrath, Kathleen E; Huijbers, Ivo J; Philipsen, Sjaak; von Lindern, Marieke; Zwart, Wilbert; Beijersbergen, Roderick L; Palis, James; van den Berk, Paul C M; Jacobs, Heinz.

Proc Natl Acad Sci U S A ; 120(4): e2216055120, 2023 Jan 24.

Artigo em Inglês | MEDLINE | ID: mdl-36669105

2.

An evolutionarily ancient mechanism for regulation of hemoglobin expression in vertebrate red cells.

Miyata, Masato; Gillemans, Nynke; Hockman, Dorit; Demmers, Jeroen A A; Cheng, Jan-Fang; Hou, Jun; Salminen, Matti; Fisher, Christopher A; Taylor, Stephen; Gibbons, Richard J; Ganis, Jared J; Zon, Leonard I; Grosveld, Frank; Mulugeta, Eskeatnaf; Sauka-Spengler, Tatjana; Higgs, Douglas R; Philipsen, Sjaak.

Blood ; 136(3): 269-278, 2020 07 16.

Artigo em Inglês | MEDLINE | ID: mdl-32396940

3.

Hemoglobin switching in mice carrying the Klf1^Nan variant.

Korporaal, Anne; Gillemans, Nynke; Heshusius, Steven; Cantú, Ileana; van den Akker, Emile; van Dijk, Thamar B; von Lindern, Marieke; Philipsen, Sjaak.

Haematologica ; 106(2): 464-473, 2021 02 01.

Artigo em Inglês | MEDLINE | ID: mdl-32467144

4.

Mild dyserythropoiesis and ß-like globin gene expression imbalance due to the loss of histone chaperone ASF1B.

Papadopoulos, Petros; Kafasi, Athanassia; De Cuyper, Iris M; Barroca, Vilma; Lewandowski, Daniel; Kadri, Zahra; Veldthuis, Martijn; Berghuis, Jeffrey; Gillemans, Nynke; Benavente Cuesta, Celina María; Grosveld, Frank G; van Zwieten, Rob; Philipsen, Sjaak; Vernet, Muriel; Gutiérrez, Laura; Patrinos, George P.

Hum Genomics ; 14(1): 39, 2020 10 16.

Artigo em Inglês | MEDLINE | ID: mdl-33066815

5.

Identification of a novel distal regulatory element of the human Neuroglobin gene by the chromosome conformation capture approach.

Tam, Kin Tung; Chan, Ping Kei; Zhang, Wei; Law, Pui Pik; Tian, Zhipeng; Fung Chan, Godfrey Chi; Philipsen, Sjaak; Festenstein, Richard; Tan-Un, Kian Cheng.

Nucleic Acids Res ; 45(1): 115-126, 2017 01 09.

Artigo em Inglês | MEDLINE | ID: mdl-27651453

6.

Evolution of hemoglobin loci and their regulatory elements.

Philipsen, Sjaak; Hardison, Ross C.

Blood Cells Mol Dis ; 70: 2-12, 2018 05.

Artigo em Inglês | MEDLINE | ID: mdl-28811072

7.

A ubiquitin ligase toggles red cell differentiation.

Verheul, Thijs C J; Philipsen, Sjaak.

Blood ; 137(2): 143-144, 2021 01 14.

Artigo em Inglês | MEDLINE | ID: mdl-33443559

8.

Krüppeling erythropoiesis: an unexpected broad spectrum of human red blood cell disorders due to KLF1 variants.

Perkins, Andrew; Xu, Xiangmin; Higgs, Douglas R; Patrinos, George P; Arnaud, Lionel; Bieker, James J; Philipsen, Sjaak.

Blood ; 127(15): 1856-62, 2016 Apr 14.

Artigo em Inglês | MEDLINE | ID: mdl-26903544

9.

GATA1-Deficient Dendritic Cells Display Impaired CCL21-Dependent Migration toward Lymph Nodes Due to Reduced Levels of Polysialic Acid.

Scheenstra, Maaike R; De Cuyper, Iris M; Branco-Madeira, Filipe; de Bleser, Pieter; Kool, Mirjam; Meinders, Marjolein; Hoogenboezem, Mark; Mul, Erik; Wolkers, Monika C; Salerno, Fiamma; Nota, Benjamin; Saeys, Yvan; Klarenbeek, Sjoerd; van IJcken, Wilfred F J; Hammad, Hamida; Philipsen, Sjaak; van den Berg, Timo K; Kuijpers, Taco W; Lambrecht, Bart N; Gutiérrez, Laura.

J Immunol ; 197(11): 4312-4324, 2016 12 01.

Artigo em Inglês | MEDLINE | ID: mdl-27815426

10.

Chtop (Chromatin target of Prmt1) auto-regulates its expression level via intron retention and nonsense-mediated decay of its own mRNA.

Izumikawa, Keiichi; Yoshikawa, Harunori; Ishikawa, Hideaki; Nobe, Yuko; Yamauchi, Yoshio; Philipsen, Sjaak; Simpson, Richard J; Isobe, Toshiaki; Takahashi, Nobuhiro.

Nucleic Acids Res ; 44(20): 9847-9859, 2016 Nov 16.

Artigo em Inglês | MEDLINE | ID: mdl-27683223

11.

Sp2 is the only glutamine-rich specificity protein with minor impact on development and differentiation in myelinating glia.

Wegener, Amélie; Küspert, Melanie; Sock, Elisabeth; Philipsen, Sjaak; Suske, Guntram; Wegner, Michael.

J Neurochem ; 140(2): 245-256, 2017 01.

Artigo em Inglês | MEDLINE | ID: mdl-27889927

12.

Chtop is a component of the dynamic TREX mRNA export complex.

Chang, Chung-Te; Hautbergue, Guillaume M; Walsh, Matthew J; Viphakone, Nicolas; van Dijk, Thamar B; Philipsen, Sjaak; Wilson, Stuart A.

EMBO J ; 32(3): 473-86, 2013 Feb 06.

Artigo em Inglês | MEDLINE | ID: mdl-23299939

13.

A crucial role for the ubiquitously expressed transcription factor Sp1 at early stages of hematopoietic specification.

Gilmour, Jane; Assi, Salam A; Jaegle, Ulrike; Kulu, Divine; van de Werken, Harmen; Clarke, Deborah; Westhead, David R; Philipsen, Sjaak; Bonifer, Constanze.

Development ; 141(12): 2391-401, 2014 Jun.

Artigo em Inglês | MEDLINE | ID: mdl-24850855

14.

Sp1/Sp3 transcription factors regulate hallmarks of megakaryocyte maturation and platelet formation and function.

Meinders, Marjolein; Kulu, Divine I; van de Werken, Harmen J G; Hoogenboezem, Mark; Janssen, Hans; Brouwer, Rutger W W; van Ijcken, Wilfred F J; Rijkers, Erik-Jan; Demmers, Jeroen A A; Krüger, Imme; van den Berg, Timo K; Suske, Guntram; Gutiérrez, Laura; Philipsen, Sjaak.

Blood ; 125(12): 1957-67, 2015 Mar 19.

Artigo em Inglês | MEDLINE | ID: mdl-25538045

15.

ASH1L (a histone methyltransferase protein) is a novel candidate globin gene regulator revealed by genetic study of an English family with beta-thalassaemia unlinked to the beta-globin locus.

Breton, Amandine; Theodorou, Andria; Aktuna, Suleyman; Sonzogni, Laura; Darling, David; Chan, Lucas; Menzel, Stephan; van der Spek, Peter J; Swagemakers, Sigrid M A; Grosveld, Frank; Philipsen, Sjaak; Thein, Swee Lay.

Br J Haematol ; 175(3): 525-530, 2016 Nov.

Artigo em Inglês | MEDLINE | ID: mdl-27434206

16.

Mutations in Kruppel-like factor 1 cause transfusion-dependent hemolytic anemia and persistence of embryonic globin gene expression.

Viprakasit, Vip; Ekwattanakit, Supachai; Riolueang, Suchada; Chalaow, Nipon; Fisher, Chris; Lower, Karen; Kanno, Hitoshi; Tachavanich, Kalaya; Bejrachandra, Sasithorn; Saipin, Jariya; Juntharaniyom, Monthana; Sanpakit, Kleebsabai; Tanphaichitr, Voravarn S; Songdej, Duantida; Babbs, Christian; Gibbons, Richard J; Philipsen, Sjaak; Higgs, Douglas R.

Blood ; 123(10): 1586-95, 2014 Mar 06.

Artigo em Inglês | MEDLINE | ID: mdl-24443441

17.

A new twist to the GATA switch.

Philipsen, Sjaak.

Blood ; 122(20): 3391-2, 2013 Nov 14.

Artigo em Inglês | MEDLINE | ID: mdl-24235125

18.

Erythropoiesis and globin switching in compound Klf1::Bcl11a mutant mice.

Esteghamat, Fatemehsadat; Gillemans, Nynke; Bilic, Ivan; van den Akker, Emile; Cantù, Ileana; van Gent, Teus; Klingmüller, Ursula; van Lom, Kirsten; von Lindern, Marieke; Grosveld, Frank; Bryn van Dijk, Thamar; Busslinger, Meinrad; Philipsen, Sjaak.

Blood ; 121(13): 2553-62, 2013 Mar 28.

Artigo em Inglês | MEDLINE | ID: mdl-23361909

19.

Hypoxia increases membrane metallo-endopeptidase expression in a novel lung cancer ex vivo model - role of tumor stroma cells.

Leithner, Katharina; Wohlkoenig, Christoph; Stacher, Elvira; Lindenmann, Jörg; Hofmann, Nicole A; Gallé, Birgit; Guelly, Christian; Quehenberger, Franz; Stiegler, Philipp; Smolle-Jüttner, Freyja-Maria; Philipsen, Sjaak; Popper, Helmut H; Hrzenjak, Andelko; Olschewski, Andrea; Olschewski, Horst.

BMC Cancer ; 14: 40, 2014 Jan 25.

Artigo em Inglês | MEDLINE | ID: mdl-24460801

20.

Five friends of methylated chromatin target of protein-arginine-methyltransferase[prmt]-1 (chtop), a complex linking arginine methylation to desumoylation.

Fanis, Pavlos; Gillemans, Nynke; Aghajanirefah, Ali; Pourfarzad, Farzin; Demmers, Jeroen; Esteghamat, Fatemehsadat; Vadlamudi, Ratna K; Grosveld, Frank; Philipsen, Sjaak; van Dijk, Thamar B.

Mol Cell Proteomics ; 11(11): 1263-73, 2012 Nov.

Artigo em Inglês | MEDLINE | ID: mdl-22872859

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