Detalhe da pesquisa
1.
Synthesis and preliminary biological evaluation of potent and selective 2-(3-alkoxy-1-azetidinyl) quinolines as novel PDE10A inhibitors with improved solubility.
Bioorg Med Chem
; 22(23): 6570-6585, 2014 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25456383
2.
The optimization of aminooxadiazoles as orally active inhibitors of Cdc7.
Bioorg Med Chem Lett
; 23(23): 6396-400, 2013 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24120542
3.
Novel 5- and 6-subtituted benzothiazoles with improved physicochemical properties: potent S1P1 agonists with in vivo lymphocyte-depleting activity.
Bioorg Med Chem Lett
; 22(1): 628-33, 2012 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22100314
4.
Isoform-selective thiazolo[5,4-b]pyridine S1P1 agonists possessing acyclic amino carboxylate head-groups.
Bioorg Med Chem Lett
; 22(4): 1779-83, 2012 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22257889
5.
Quinolinone-based agonists of S1P1: use of a N-scan SAR strategy to optimize in vitro and in vivo activity.
Bioorg Med Chem Lett
; 22(1): 527-31, 2012 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22104144
6.
Discovery of a Covalent Inhibitor of KRASG12C (AMG 510) for the Treatment of Solid Tumors.
J Med Chem
; 63(1): 52-65, 2020 01 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-31820981
7.
Structure-guided design of substituted aza-benzimidazoles as potent hypoxia inducible factor-1alpha prolyl hydroxylase-2 inhibitors.
Bioorg Med Chem Lett
; 18(18): 5023-6, 2008 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18755588
8.
Optimization of a Potent, Orally Active S1P1 Agonist Containing a Quinolinone Core.
ACS Med Chem Lett
; 3(1): 74-8, 2012 Jan 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-24900374
9.
4-Methoxy-N-[2-(trifluoromethyl)biphenyl-4-ylcarbamoyl]nicotinamide: A Potent and Selective Agonist of S1P1.
ACS Med Chem Lett
; 2(10): 752-7, 2011 Oct 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-24900263
10.
Discovery of a Potent, S1P3-Sparing Benzothiazole Agonist of Sphingosine-1-Phosphate Receptor 1 (S1P1).
ACS Med Chem Lett
; 2(2): 102-6, 2011 Feb 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-24900287