Detalhe da pesquisa
1.
Discovery of potent and efficacious pyrrolopyridazines as dual JAK1/3 inhibitors.
Bioorg Med Chem Lett
; 27(14): 3101-3106, 2017 07 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28539220
2.
Discovery of pyrrolo[1,2-b]pyridazine-3-carboxamides as Janus kinase (JAK) inhibitors.
Bioorg Med Chem Lett
; 24(24): 5721-5726, 2014 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25453808
3.
The identification of novel p38α isoform selective kinase inhibitors having an unprecedented p38α binding mode.
Bioorg Med Chem Lett
; 23(14): 4120-6, 2013 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23746475
4.
Discovery of pyrrolo[2,1-f][1,2,4]triazine C6-ketones as potent, orally active p38α MAP kinase inhibitors.
Bioorg Med Chem Lett
; 21(15): 4633-7, 2011 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21705217
5.
Utilization of a nitrogen-sulfur nonbonding interaction in the design of new 2-aminothiazol-5-yl-pyrimidines as p38α MAP kinase inhibitors.
Bioorg Med Chem Lett
; 20(19): 5864-8, 2010 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20732813
6.
5-amino-pyrazoles as potent and selective p38α inhibitors.
Bioorg Med Chem Lett
; 20(23): 6886-9, 2010 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21035336
7.
Discovery of a JAK1/3 Inhibitor and Use of a Prodrug To Demonstrate Efficacy in a Model of Rheumatoid Arthritis.
ACS Med Chem Lett
; 10(3): 306-311, 2019 Mar 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-30891131
8.
Design, synthesis, and anti-inflammatory properties of orally active 4-(phenylamino)-pyrrolo[2,1-f][1,2,4]triazine p38alpha mitogen-activated protein kinase inhibitors.
J Med Chem
; 51(1): 4-16, 2008 Jan 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-18072718
9.
Benzothiazole based inhibitors of p38alpha MAP kinase.
Bioorg Med Chem Lett
; 18(6): 1874-9, 2008 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18296051
10.
Pyrazolo-pyrimidines: a novel heterocyclic scaffold for potent and selective p38 alpha inhibitors.
Bioorg Med Chem Lett
; 18(8): 2652-7, 2008 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18359226
11.
Synthesis and SAR of new pyrrolo[2,1-f][1,2,4]triazines as potent p38 alpha MAP kinase inhibitors.
Bioorg Med Chem Lett
; 18(8): 2739-44, 2008 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18364256
12.
The discovery of (R)-2-(sec-butylamino)-N-(2-methyl-5-(methylcarbamoyl)phenyl) thiazole-5-carboxamide (BMS-640994)-A potent and efficacious p38alpha MAP kinase inhibitor.
Bioorg Med Chem Lett
; 18(6): 1762-7, 2008 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18313298
13.
Identification of a Potent, Selective, and Efficacious Phosphatidylinositol 3-Kinase δ (PI3Kδ) Inhibitor for the Treatment of Immunological Disorders.
J Med Chem
; 60(12): 5193-5208, 2017 06 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-28541707
14.
2-aminothiazole as a novel kinase inhibitor template. Structure-activity relationship studies toward the discovery of N-(2-chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1- piperazinyl)]-2-methyl-4-pyrimidinyl]amino)]-1,3-thiazole-5-carboxamide (dasatinib, BMS-354825) as a potent pan-Src kinase inhibitor.
J Med Chem
; 49(23): 6819-32, 2006 Nov 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-17154512
15.
5-Cyanopyrimidine derivatives as a novel class of potent, selective, and orally active inhibitors of p38alpha MAP kinase.
J Med Chem
; 48(20): 6261-70, 2005 Oct 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-16190753
16.
Discovery of N-(2-chloro-6-methyl- phenyl)-2-(6-(4-(2-hydroxyethyl)- piperazin-1-yl)-2-methylpyrimidin-4- ylamino)thiazole-5-carboxamide (BMS-354825), a dual Src/Abl kinase inhibitor with potent antitumor activity in preclinical assays.
J Med Chem
; 47(27): 6658-61, 2004 Dec 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-15615512
17.
The discovery of orally active triaminotriazine aniline amides as inhibitors of p38 MAP kinase.
J Med Chem
; 47(25): 6283-91, 2004 Dec 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-15566298
18.
Discovery of 4-(5-(cyclopropylcarbamoyl)-2-methylphenylamino)-5-methyl-N-propylpyrrolo[1,2-f][1,2,4]triazine-6-carboxamide (BMS-582949), a clinical p38α MAP kinase inhibitor for the treatment of inflammatory diseases.
J Med Chem
; 53(18): 6629-39, 2010 Sep 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-20804198
19.
Synthesis and SAR of p38alpha MAP kinase inhibitors based on heterobicyclic scaffolds.
Bioorg Med Chem Lett
; 17(18): 5019-24, 2007 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-17664068
20.
Discovery of 2-amino-heteroaryl-benzothiazole-6-anilides as potent p56(lck) inhibitors.
Bioorg Med Chem Lett
; 13(15): 2587-90, 2003 Aug 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-12852972