Detalhe da pesquisa
1.
Comparison of percentile tables and algorithm-based calculators for classification of blood pressures in children and adolescents with obesity: A secondary analysis of a clinical trial.
J Paediatr Child Health
; 59(2): 242-246, 2023 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-36404725
2.
Discovery and structure-based design of 4,6-diaminonicotinamides as potent and selective IRAK4 inhibitors.
Bioorg Med Chem Lett
; 27(21): 4908-4913, 2017 11 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28947151
3.
Discovery of potent and efficacious pyrrolopyridazines as dual JAK1/3 inhibitors.
Bioorg Med Chem Lett
; 27(14): 3101-3106, 2017 07 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28539220
4.
Discovery of highly potent, selective, covalent inhibitors of JAK3.
Bioorg Med Chem Lett
; 27(20): 4622-4625, 2017 10 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28927786
5.
Tyrosine Kinase 2-mediated Signal Transduction in T Lymphocytes Is Blocked by Pharmacological Stabilization of Its Pseudokinase Domain.
J Biol Chem
; 290(17): 11061-74, 2015 Apr 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-25762719
6.
Identification and synthesis of potent and selective pyridyl-isoxazole based agonists of sphingosine-1-phosphate 1 (S1P1).
Bioorg Med Chem Lett
; 26(10): 2470-2474, 2016 05 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27055941
7.
Discovery of pyrrolo[1,2-b]pyridazine-3-carboxamides as Janus kinase (JAK) inhibitors.
Bioorg Med Chem Lett
; 24(24): 5721-5726, 2014 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25453808
8.
Organic chemistry: Toolkit of reagents to aid drug discovery.
Nature
; 492(7427): 45-6, 2012 Dec 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-23201687
9.
Imidazo[4,5-d]thiazolo[5,4-b]pyridine based inhibitors of IKK2: synthesis, SAR, PK/PD and activity in a preclinical model of rheumatoid arthritis.
Bioorg Med Chem Lett
; 21(1): 383-6, 2011 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21087862
10.
Novel tricyclic inhibitors of IKK2: discovery and SAR leading to the identification of 2-methoxy-N-((6-(1-methyl-4-(methylamino)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-7-yl)pyridin-2-yl)methyl)acetamide (BMS-066).
Bioorg Med Chem Lett
; 21(23): 7006-12, 2011 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22018461
11.
An innovative kinome platform to accelerate small-molecule inhibitor discovery and optimization from hits to leads.
Drug Discov Today
; 26(5): 1115-1125, 2021 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-33497831
12.
Identification of RIPK3 Type II Inhibitors Using High-Throughput Mechanistic Studies in Hit Triage.
ACS Med Chem Lett
; 11(3): 266-271, 2020 Mar 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-32184955
13.
Optimization of Nicotinamides as Potent and Selective IRAK4 Inhibitors with Efficacy in a Murine Model of Psoriasis.
ACS Med Chem Lett
; 11(7): 1402-1409, 2020 Jul 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-32676146
14.
Periodic, partial inhibition of IkappaB Kinase beta-mediated signaling yields therapeutic benefit in preclinical models of rheumatoid arthritis.
J Pharmacol Exp Ther
; 331(2): 349-60, 2009 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-19652024
15.
Identification of potent pyrimidine inhibitors of phosphodiesterase 7 (PDE7) and their ability to inhibit T cell proliferation.
Bioorg Med Chem Lett
; 19(7): 1935-8, 2009 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19272774
16.
Synthesis, initial SAR and biological evaluation of 1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-4-amine derived inhibitors of IkappaB kinase.
Bioorg Med Chem Lett
; 19(10): 2646-9, 2009 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19376699
17.
Discovery of a JAK1/3 Inhibitor and Use of a Prodrug To Demonstrate Efficacy in a Model of Rheumatoid Arthritis.
ACS Med Chem Lett
; 10(3): 306-311, 2019 Mar 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-30891131
18.
Highly Selective Inhibition of Tyrosine Kinase 2 (TYK2) for the Treatment of Autoimmune Diseases: Discovery of the Allosteric Inhibitor BMS-986165.
J Med Chem
; 62(20): 8973-8995, 2019 10 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-31318208
19.
Discovery and Structure-Activity Relationship (SAR) of a Series of Ethanolamine-Based Direct-Acting Agonists of Sphingosine-1-phosphate (S1P1).
J Med Chem
; 59(13): 6248-64, 2016 07 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-27309907
20.
Potent and Selective Agonists of Sphingosine 1-Phosphate 1 (S1P1): Discovery and SAR of a Novel Isoxazole Based Series.
J Med Chem
; 59(6): 2820-40, 2016 Mar 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-26924461