Detalhe da pesquisa
1.
Membrane Permeability in a Large Macrocyclic Peptide Driven by a Saddle-Shaped Conformation.
J Am Chem Soc
; 146(7): 4582-4591, 2024 Feb 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-38330910
2.
Preclinical characterization of the absorption and disposition of the brain penetrant PI3K/mTOR inhibitor paxalisib and prediction of its pharmacokinetics and efficacy in human.
Xenobiotica
; 54(2): 64-74, 2024 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-38197324
3.
Evaluation of bottom-up modeling of the blood-brain barrier to improve brain penetration prediction via physiologically based pharmacokinetic modeling.
Biopharm Drug Dispos
; 44(1): 60-70, 2023 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-36630933
4.
An Integrated Strategy for Assessing the Metabolic Stability and Biotransformation of Macrocyclic Peptides in Drug Discovery toward Oral Delivery.
Anal Chem
; 94(4): 2032-2041, 2022 02 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-35041378
5.
Evaluation of Ipatasertib Interactions with Itraconazole and Coproporphyrin I and III in a Single Drug Interaction Study in Healthy Subjects.
J Pharmacol Exp Ther
; 378(2): 87-95, 2021 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-34049965
6.
Novel antibody-antibiotic conjugate eliminates intracellular S. aureus.
Nature
; 527(7578): 323-8, 2015 Nov 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-26536114
7.
Calibrating the In Vitro-In Vivo Correlation for OATP-Mediated Drug-Drug Interactions with Rosuvastatin Using Static and PBPK Models.
Drug Metab Dispos
; 48(12): 1264-1270, 2020 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-33037044
8.
Comprehensive Evaluation of Bile Acid Homeostasis in Human Hepatocyte Co-Culture in the Presence of Troglitazone, Pioglitazone, and Acetylsalicylic Acid.
Mol Pharm
; 16(10): 4230-4240, 2019 10 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-31509422
9.
Design of a brain-penetrant CDK4/6 inhibitor for glioblastoma.
Bioorg Med Chem Lett
; 29(16): 2294-2301, 2019 08 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-31307887
10.
Evaluating the Utility of Canine Mdr1 Knockout Madin-Darby Canine Kidney I Cells in Permeability Screening and Efflux Substrate Determination.
Mol Pharm
; 15(11): 5103-5113, 2018 11 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-30222362
11.
Brain Distribution and Efficacy of the Brain Penetrant PI3K Inhibitor GDC-0084 in Orthotopic Mouse Models of Human Glioblastoma.
Drug Metab Dispos
; 44(12): 1881-1889, 2016 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-27638506
12.
Differential effects of Rifampin and Ketoconazole on the blood and liver concentration of atorvastatin in wild-type and Cyp3a and Oatp1a/b knockout mice.
Drug Metab Dispos
; 42(6): 1067-73, 2014 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-24671957
13.
Role of P-glycoprotein on the brain penetration and brain pharmacodynamic activity of the MEK inhibitor cobimetinib.
Mol Pharm
; 11(11): 4199-207, 2014 Nov 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-25243894
14.
Variability in P-glycoprotein inhibitory potency (IC50) using various in vitro experimental systems: implications for universal digoxin drug-drug interaction risk assessment decision criteria.
Drug Metab Dispos
; 41(7): 1347-66, 2013 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-23620485
15.
Evaluating the in vitro inhibition of UGT1A1, OATP1B1, OATP1B3, MRP2, and BSEP in predicting drug-induced hyperbilirubinemia.
Mol Pharm
; 10(8): 3067-75, 2013 Aug 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-23750830
16.
Ternary complex dissociation kinetics contribute to mutant-selective EGFR degradation.
Cell Chem Biol
; 2023 Feb 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-36773603
17.
Preclinical assessment of the absorption and disposition of the phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor GDC-0980 and prediction of its pharmacokinetics and efficacy in human.
Drug Metab Dispos
; 40(9): 1785-96, 2012 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-22696419
18.
Preclinical disposition of GDC-0973 and prospective and retrospective analysis of human dose and efficacy predictions.
Drug Metab Dispos
; 40(5): 919-27, 2012 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-22315332
19.
Preclinical stereoselective disposition and toxicokinetics of two novel MET inhibitors.
Xenobiotica
; 42(5): 456-65, 2012 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-22122353
20.
Turning the Other Cheek: Influence of the cis-Tetrafluorocyclohexyl Motif on Physicochemical and Metabolic Properties.
ACS Med Chem Lett
; 13(9): 1517-1523, 2022 Sep 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-36105337