RESUMO
Sweet's syndrome or acute febrile neutrophilic dermatosis (SS) is characterized by the sudden onset of painful erythematous lesions (papules, nodules, and plaques) together with fever and neutrophilia. The lesions are typically located on hands, arms, upper trunk, neck and face, showing an asymmetric distribution. Acute phase reactants are usually elevated and dermal infiltration of neutrophils without vasculitis is seen on skin biopsies. It is considered as a marker of systemic disease in over half of the cases, and is associated with infections, inflammatory bowel disease, autoimmune connective tissue disorders and various neoplasias. Its association with Crohn's disease (CD) is unusual and it appears mainly in association with colonic involvement. Fewer than 50 cases have been published in the medical literature since its first description in 1964, some concurrent with the first episode of CD. We present two patients with Crohn's disease and Sweet's syndrome diagnosed in our department at the time of CD diagnosis, as well as their response to treatment, subsequent course of the disease, and a review of the scientific literature.
Assuntos
Doença de Crohn/complicações , Síndrome de Sweet/complicações , Adulto , Anti-Inflamatórios/uso terapêutico , Colonoscopia , Doença de Crohn/diagnóstico , Doença de Crohn/terapia , Eritema/etiologia , Eritema/patologia , Feminino , Hidratação , Humanos , Masculino , Pessoa de Meia-Idade , Prednisona/uso terapêutico , Pele/patologia , Síndrome de Sweet/diagnóstico , Síndrome de Sweet/terapia , Tomografia Computadorizada por Raios XAssuntos
Doenças dos Genitais Femininos , Doenças dos Genitais Masculinos , Feminino , Genitália , Humanos , Masculino , ÚlceraRESUMO
We revised the most important antifungal drugs used in cutaneous mycosis. We emphasize in pharmacokinetics, drug adverse reactions and its management in the different types of pathology.
RESUMO
Tinea incognito represents a new entity caused basically by the careless application of corticosteroidal creams. We present a 71-year-old man with disseminated erythematous and squamous lesions treated with corticosteroid creams for seven months; the clinical aspect worsened and new pustular lesions appeared. The diagnosis of disseminated inflammatory tinea was confirmed by culture, with the growth of Trichophyton mentagrophytes. We comment on the clinical findings and the factors that contribute to spread the process.