Detalhe da pesquisa
1.
Discovery and Lead-Optimization of 4,5-Dihydropyrazoles as Mono-Kinase Selective, Orally Bioavailable and Efficacious Inhibitors of Receptor Interacting Protein 1 (RIP1) Kinase.
J Med Chem
; 62(10): 5096-5110, 2019 05 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-31013427
2.
Design, synthesis and evaluation of trifluoromethane sulfonamide derivatives as new potent and selective peroxisome proliferator-activated receptor alpha agonists.
Bioorg Med Chem Lett
; 18(2): 710-5, 2008 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18060776
3.
The discovery of equipotent PPARalpha/gamma dual activators.
Bioorg Med Chem Lett
; 18(23): 6251-4, 2008 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18947994
4.
Design and evaluation of a novel series of 2,3-oxidosqualene cyclase inhibitors with low systemic exposure, relationship between pharmacokinetic properties and ocular toxicity.
Bioorg Med Chem
; 16(11): 6218-32, 2008 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18467104
5.
Substituted 2-[(4-aminomethyl)phenoxy]-2-methylpropionic acid PPARalpha agonists. 1. Discovery of a novel series of potent HDLc raising agents.
J Med Chem
; 50(4): 685-95, 2007 Feb 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-17243659
6.
Fragment-Based Approach to the Development of an Orally Bioavailable Lactam Inhibitor of Lipoprotein-Associated Phospholipase A2 (Lp-PLA2).
J Med Chem
; 59(23): 10738-10749, 2016 12 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-27933945
7.
Exploitation of a Novel Binding Pocket in Human Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) Discovered through X-ray Fragment Screening.
J Med Chem
; 59(11): 5356-67, 2016 06 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-27167608