Dentoalveolar oral surgery in children and adolescents: organization and surgical treatment in a large, Danish municipal dental service.

OBJECTIVE: To describe a population-based organization of dentoalveolar surgical service for 0 to 18-year old subjects in a Danish municipal dental service, and analyze the type of dentoalveolar surgical interventions needed. MATERIAL AND METHODS: The study was conducted in the Municipality of Aarhus, Denmark during five consecutive school-years. An internal referral system was established within the municipality where patients could be referred to colleagues with a higher level of competencies and more experiences with paediatric dentoalveolar surgery. The analysis includes a total of 1812 children and a total of 2854 surgical interventions. RESULTS: Almost 80% of the patients, representing more than 80% of the dentoalveolar surgical interventions needed, were referred internally. Denudations were the most frequent treatment type (40.3%) carried out, followed by removal of third molars (18.0%). Furthermore, 22 odontomas and 100 supernumerary teeth were removed. CONCLUSIONS: The need of dentoalveolar surgery in children and adolescents is relatively low, but includes a wide range of interventions. An organizational system, where dentists can refer to colleagues who have developed special competencies in this field, results in most of these surgical patients being referred and treated internally.

Developmental enamel defects in children born preterm: a systematic review.

The purpose of this review was to evaluate the association between developmental enamel defects and children born preterm. An identical search was performed in PubMed and Embase and was limited to human studies and studies written in English, German, Danish, Swedish, or Norwegian. Reviews, case studies, and case series were excluded. A total of 283 articles were identified. Twenty-three publications, of which 19 were follow-up studies, two were case-control studies, and two were cross-sectional surveys, were enrolled in the review. The majority of the studies (n = 17) dealt with enamel hypoplasia of the primary teeth. Thirteen studies reported an association between preterm birth and enamel hypoplasia, and, in addition, few studies reported an increased risk of enamel opacities in the primary teeth, in children with a birth weight <1500 g. Seven studies dealt with enamel disturbances of the permanent teeth, four of which suggested an increased risk of enamel opacities. This systematic review suggests an increased risk of enamel hypoplasia in primary teeth of children born preterm and enamel opacities in very-low birth-weight children. A larger number of well-designed studies are, however, needed in order to increase the validity of the studies.

A placebo-controlled, double-blind, crossover trial on analgesic effect of nitrous oxide-oxygen inhalation.

BACKGROUND: The sedative effect of nitrous oxide-oxygen (N2 O/O2 ) inhalation is relatively well established. Less in known about its analgesic effect. AIM: To determine the analgesic effect of N2 O/O2 inhalation on pulp sensitivity and jaw muscle pressure pain threshold in children. DESIGN: A placebo-controlled, double-blind, crossover trial with random allocation to two sequences: atmospheric air at the first session and N2 O/O2 at the second; or N2 O/O2 at the first session and atmospheric air at the second. Measurements included reaction time, pulp pain sensitivity, jaw muscle pressure pain thresholds and a VAS score of overall discomfort from the pain tests. RESULTS: Fifty-six children (12-15 years) completed the study. N2 O/O2 inhalation increased reaction time (P < 0.001). Pulp pain sensitivity was reduced during N2 O/O2 inhalation (P < 0.001), but no effect was found after adjustment for the increased reaction time. Pressure pain threshold on the jaw muscle was also reduced during N2 O/O2 inhalation (P < 0.001), also after adjustment for reaction time (P < 0.005). An effect was still found 10 min after the mask had been removed (P = 0.03). No effect on VAS scores of discomfort from the tests could be found. CONCLUSIONS: No analgesic effect of N2 O/O2 inhalation on pulp pain sensitivity was found, whereas an increased pressure pain threshold of jaw muscles was found.

Microdontia and hypodontia of premolars and permanent molars in childhood cancer survivors after chemotherapy.

BACKGROUND: Adverse long-term general and dental health effects of cancer and cancer therapy during childhood have been reported. AIM: To examine the association between chemotherapy before the age of 8 years and (1): microdontia; (2): hypodontia of premolars and permanent molars. MATERIAL AND METHODS: In The Danish Registry of Childhood Cancer (DBCR), we identified 203 children who met the following inclusion criteria: (1) age below 8 years at the start of treatment; (2) age between 12 to 18 years upon dental examination; (3) had received chemotherapy The exclusion criterion was radiotherapy to the head and neck. A total of 150 children fulfilled the inclusion criteria. As controls, a random sample of 193 age-matched unexposed children was included. RESULTS: Microdontia was found in a total of 88 teeth in 29 (19.3%) of the 150 children who had been exposed to chemotherapy, while none of the controls had microdontia of premolars or permanent molars (difference: 19.3%; 95% CL: 13.5%; 26.4%). The earlier the exposure, the more frequent was microdontia. We found a total of 27 missing premolars and permanent molars in 14 (9.3%) of the exposed children and a total of 18 missing premolars and permanent molars in 8 (4.1%) of the controls (difference: 5.2%; 95% CL: -0.1%; 11.3%). CONCLUSION: The present study confirms findings from previous studies that chemotherapy, especially in very young children, causes microdontia and hypodontia of premolars and permanent molars.

Craniofacial morphology in patients with hypophosphatemic rickets: a cephalometric study focusing on differences between bone of cartilaginous and intramembranous origin.

Hypophosphatemic rickets (HR) are diseases characterized by deficient mineralization of bone due to abnormal renal wasting of phosphate. Deformation of bony structures of cartilaginous origin has been described as a major characteristic in patients with HR, but little is known about the impact on bony structures of intramembranous origin. The aim of the present study was to describe the osseous morphology of the craniofacial structures in patients with HR compared to healthy controls, and to investigate the impact of different bone origin on the osseous morphology. Fifty-three patients with HR (17 males, 36 females), aged 3-74 yrs, were included. Fifty HR patients had dominant X-linked disease, and in three patients no mutations were identified. A total of 79 healthy individuals (37 males, 42 females), aged 6-79 yrs, with normal occlusion served as controls. Significant cephalometric differences were found between HR patients and controls. In HR patients, the cranial base was flattened and the depth of the posterior cranial fossa was decreased. The anterior height of the cranium, the angle nasion-sella-frontale, and the thickness of theca were increased. The length of the nasal bone and the height of the maxilla were reduced. In contrast, the vertical as well as the sagittal relation between the jaws were unaffected in HR patients compared to controls. In conclusion, we found that the cranial structures of cartilaginous origin as well as the structures of intramembraneous origin were affected in patients with HR.

Marginal adaptation of a low-shrinkage silorane-based composite: 1-year randomized clinical trial.

The aim of the present study was to examine the marginal adaptation of a new low-shrinkage silorane-based composite material (Filtek™ Silorane, 3M-Espe) by comparing it with a methacrylate-based composite material (CeramX™, Dentsply DeTrey). In particular, we wanted to test the hypothesis that reduced polymerization shrinkage would improve the marginal adaptation. Seventy-two patients participated in the study. A total of 158 restorations were placed in 80 premolars and 78 molars. Only Class II restorations were included, and each patient could contribute with more than one tooth. The restorations were scored at baseline and after one year. While statistical comparison of marginal adaptation at follow-up indicated better performance of CeramX™ both occlusally and approximally (p = 0.01 and p < 0.01), the low kappa value (32%) reflects the difficulty to assess marginal adaptation clinically. The reduction in polymerization shrinkage demonstrated in the laboratory was not clinically significant in the present study.

Oral health-related quality of life among survivors of childhood cancer.

BACKGROUND. Childhood cancer survivors may have experienced a high number of invasive medical and dental procedures, which may affect their oral health-related quality of life (OHRQoL). AIM. To compare children who have survived cancer and children without cancer with respect to OHRQoL. DESIGN. In a cross-sectional study, we compared the OHRQoL of children treated for cancer at Aalborg Hospital with the OHRQoL of classmates without cancer. All children answered The Danish version of the Child Perceptions Questionnaire (CPQ). Children aged 8-10 (n = 95) answered CPQ(8-10) , with 27 questions, and children aged 11-14 (n = 138) answered the CPQ(11-14,) with 39 questions. RESULTS. Children with cancer rated their OHRQoL better or equal to those without cancer. The mean overall CPQ(8-10) score was 5.6 (95% CI: 2.5-8.6) among 18 children who have survived cancer and 8.8 (95% CI: 7.3-10.3) among those without cancer (n = 77); the mean difference was -3.3 (95% CI: -6.5 to 0.1). The overall mean CPQ(11-14) score was 12.5 (95% CI: 6.8-18.2) among 24 children who have survived cancer and 11.8 (95% CI: 10.3-13.3) among those without cancer (n = 114); the mean difference was -0.7 (95% CI: -4.9 to 6.3). CONCLUSION. Cancer and cancer treatment during childhood was not associated with a decreased OHRQoL.

Peripheral ameloblastic fibro-odontoma or peripheral developing complex odontoma: report of a case.

BACKGROUND. Peripheral (extraosseous) odontogenic tumors are rare. CASE REPORT. This report describes a case which illustrates the clinical and histopathological features of a lesion in an 8-year-old, healthy Caucasian girl that on purely morphological grounds would seem to be an ameloblastic fibro-odontoma, but may represent a case of a peripheral developing complex odontoma. CONCLUSION. Conservative surgical enucleation of the lesion was followed by unbcomplicated healing and no recurrence was seen.

An analysis of pattern of dental injuries after fall accidents in 0- to 2-year-old children - does the use of pacifier at the time of injury make a difference?

AIM: To assess the relation between type of traumatic injury and use of pacifier at the time of a fall accident in 0- to 2-year olds. MATERIAL AND METHODS: The study draws on data from the database on traumatic dental injuries at the Department of Oral and Maxillofacial Surgery, Copenhagen University Hospital. RESULTS: The study includes 1125 patients ≤ 2 years of age, representing a total of 1886 injuries. A total of 176 patients had fallen while using a pacifier, whereas 949 children suffered a fall without using a pacifier. In the pacifier group, 11.9% had crown fractures compared with 20.0% of children who had fallen without a pacifier (P = 0.012). Tooth displacement (lateral luxation, extrusion or avulsion) was relatively more frequent in children falling with a pacifier compared to children falling without a pacifier (64.8%vs 54.8%; P = 0.014). Furthermore, soft tissue injury was less frequent among the former (28.4%vs 38.3%; P = 0.013). CONCLUSIONS: Injuries occurring while using a pacifier tend to be tooth displacement rather than fractures. This is in accordance with the theoretical consideration that a blunt impact tends to favour displacement, whereas a sharp impact tends to favour fractures of the hard dental tissues.

Limited phenotypic variation of hypocalcified amelogenesis imperfecta in a Danish five-generation family with a novel FAM83H nonsense mutation.

BACKGROUND. Autosomal dominant hypocalcified amelogenesis imperfecta (ADHCAI) is a disease with severe dental manifestations. OBJECTIVES. The aims were by means of a genome-wide linkage scan to search for the gene underlying the ADHCAI phenotype in a Danish five-generation family and to study the phenotypic variation of the enamel in affected family members. RESULTS. Significant linkage was found to a locus at chromosome 8q24.3 comprising the gene FAM83H identified to be responsible for ADHCAI in other families. Subsequent sequencing of FAM83H in affected family members revealed a novel nonsense mutation, p.Y302X. Limited phenotypic variation was found among affected family members with loss of translucency and discoloration of the enamel. Extensive posteruptive loss of enamel was found in all teeth of affected subjects. The tip of the cusps on the premolars and molars and a zone along the gingival margin seemed resistant to posteruptive loss of enamel. We have screened FAM83H in another five unrelated Danish patients with a phenotype of ADHCAI similar to that in the five-generation family, and identified a de novo FAM83H nonsense mutation, p.Q452X in one of these patients. CONCLUSION. We have identified a FAM83H mutation in two of six unrelated families with ADHCAI and found limited phenotypic variation of the enamel in these patients.

Available evidence does not support use of oxalates for dentine hypersensitivity.

DATA SOURCES: Medline, CENTRAL, LILACS, TRIP Database, National Guideline Clearinghouse, OPENSigle and a number of other medical / dental databases and websites, as well as reference lists. STUDY SELECTION: Randomised controlled trials and controlled clinical trials in any language that compared oxalates with placebo or no treatment were eligible for inclusion. DATA EXTRACTION AND SYNTHESIS: Three reviewers extracted data with two people assessing quality independently using the Cochrane risk of bias domains. Standardized mean differences (SMD) were estimated by random-effects meta-analysis and heterogeneity between studies was quantified with the I2-statistic. RESULTS: 12 reports were included. Interventions were diverse and included: monohydrogen-monopotassium oxalate, ferric oxalate, di-potassium oxalate, or oxalate containing pre-polymerized resin, and combinations of monohydrogen-monopotassium and di-potassium oxalate. Follow up intervals varied between immediate to 1 year. Hypersensitivity was elicited by tactile, evaporative or thermal stimuli, and a number of outcomes used to measure pain. Risk of bias was high in a number of studies and statistical heterogeneity high. Based on 187 and 179 units (patients or teeth) in the intervention and placebo groups from seven studies, the summary SMD for 3% monohydrogen-monopotassium oxalate was -0.71 (95% Confidence Interval (CI):-1.48, 0.06), which suggests it may not be beneficial. There was no improvement with the other interventions. CONCLUSIONS: The review identified no evidence to indicate benefit from treating dentine hypersensitivity with oxalates beyond a placebo effect.

Phenotype presentation of hypophosphatemic rickets in adults.

Hypophosphatemic rickets (HR) is a group of rare disorders caused by excessive renal phosphate wasting. The purpose of this cross-sectional study of 38 HR patients was to characterize the phenotype of adult HR patients. Moreover, skeletal and endodontic severity scores were defined to assess possible gender differences in disease severity in patients with genetically verified X-linked HR. Compared to normal reference data, i.e., z = 0, HR patients had significantly lower final height, with a mean difference in z-score of -1.9 (95% CI -2.4 to -1.4, P < 0.001). Compared to paired z-scores of final height, z-scores of leg length were significantly lower and those of sitting height were significantly higher (P < 0.001), resulting in disproportion as indicated by the significantly elevated sitting height ratio, mean difference in z-score of 2.6 (95% CI 2.1-3.1, P < 0.001). Z-scores of head circumference (median 1.4, range -0.4 to 5.5, P < 0.001) and z-scores of bone mineral density (BMD) of the lumbar spine (median 1.9, range -1.5 to 8.6, P < 0.001) were significantly elevated compared to normal reference data. The relative risk (RR) of fracture was reduced (RR = 0.34, 95% CI 0.20-0.57, P < 0.001). The skeletal severity score tended to be higher in males compared to females (P = 0.07), and no gender difference in endodontic severity was found. In conclusion, adult HR patients were characterized by short stature and were disproportioned. They had elevated BMD of the lumbar spine and a reduced risk of fractures. We found a tendency for males to be more severely affected than females.

Danish dentists' and dental hygienists' knowledge of and experience with suspicion of child abuse or neglect.

BACKGROUND: Studies from several countries have shown that knowledge of child protection matters among the dental team is inadequate. No such data are available from Denmark. AIM: To describe dental teams perception of their role in child protection matters. DESIGN: A previously used questionnaire regarding the role of the dental team in child protection was adopted to Danish terminology, and mailed to a sample of Danish dentists and dental hygienists. RESULTS: A total of 1145 (76.3%) returned a questionnaire with valid data; 38.3% reported to have had suspicion of child abuse or neglect. Of those who reported a suspicion, 33.9% had reported their suspicion to social services. This was more frequent for dentists than for dental hygienists, and more frequent for respondents working in the municipal dental service than in private practice. Most frequently reported barriers towards referring suspicion to social services were uncertainty about observations, fear of violence in the family towards the child, and lack of knowledge regarding referral procedures. The majority of the respondents expressed a need for further education. CONCLUSIONS: Members of the dental team in Denmark do not seem to fill their role sufficiently in child protection matters, and perceive a need for undergraduate and continuing postgraduate training.

Risk of aggressive periodontitis in adolescent carriers of the JP2 clone of Aggregatibacter (Actinobacillus) actinomycetemcomitans in Morocco: a prospective longitudinal cohort study.

BACKGROUND: Periodontitis is a loss of supporting connective tissue and alveolar bone around teeth, and if it occurs in an aggressive form it can lead to tooth loss before the age of 20 years. Although the cause of periodontitis in general remains elusive, a particular clone (JP2) of the gram-negative rod Aggregatibacter (Actinobacillus) actinomycetemcomitans is considered a possible aetiological agent of the aggressive form in adolescents living in or originating from north and west Africa, where the disease is highly prevalent. We did a population-based longitudinal study of adolescents to assess the role of the JP2 clone in the initiation of aggressive periodontitis. METHODS: A total of 700 adolescents from public schools in Rabat, Morocco, were enrolled in the study. We used PCR to detect A actinomycetemcomitans in plaque samples (taken from molar and incisor sites) and to differentiate between the JP2 clone and other non-JP2 genotypes of the bacterium. 18 individuals were found to already have periodontitis and were excluded. The 682 periodontally healthy adolescents (mean age 12.5 years; SD 1.0) were classified according to their A actinomycetemcomitans carrier status at baseline. After 2 years, 428 (62.8%) individuals returned for re-examination, which included recording of periodontal attachment loss measured from the cemento-enamel junction to the bottom of the periodontal pockets of all teeth present. FINDINGS: Individuals who carried the JP2 clone of A actinomycetemcomitans alone (relative risk 18.0; 95% CI 7.8-41.2, p<0.0001) or together with non-JP2 clones of A actinomycetemcomitans (12.4; 5.2-29.9, p<0.0001) had a significantly increased risk of periodontal attachment loss. A much less pronounced disease risk was found in those carrying non-JP2 clones only (3.0; 1.3-7.1, p=0.012). INTERPRETATION: The JP2 clone of A actinomycetemcomitans is likely to be an important aetiological agent in initiation of periodontal attachment loss in children and adolescents. Co-occurrence of non-JP2 clones of A actinomycetemcomitans reduces the risk of development of periodontitis, suggesting competition for the ecological niche between the JP2 and non-JP2 clones of this species.

Prevalence and distribution of demarcated opacities and their sequelae in permanent 1st molars and incisors in 7 to 13-year-old Brazilian children.

OBJECTIVE: To determine the prevalence of demarcated opacities in permanent 1st molars and incisors in 7 to 13-year-old Brazilian children. MATERIAL AND METHODS: The study population comprised 292 children from a middle social class public school in Rio de Janeiro, Brazil. Children with all 1st permanent molars erupted were eligible for participation. Clinical examination was performed by two calibrated examiners who recorded demarcated opacities, post-eruptive breakdown, atypical restorations, and extractions due to demarcated opacities. Forty-three children had at least one molar that could not be examined, which left 249 children for the data analysis. RESULTS: One hundred children (40.2%) had one or more 1st molars with demarcated opacities with a mean number of 1.98 (SD 1.09) affected molars. The number of affected incisors increased with increasing number of affected molars. Twenty-two (18.6%) of 118 children with unaffected 1st molars had affected incisors. Demarcated opacities were the most frequent defect, and 1st molars and upper central incisors were the most frequently affected teeth. Among children with demarcated opacities in 1st molars, 20 (20%) had post-eruptive breakdown. CONCLUSIONS: A high prevalence of demarcated opacities, possibly resulting in disintegration of the tooth crown, has been found in Brazilian children.

Hypocalcified type of amelogenesis imperfecta in a large family: clinical, radiographic, and histological findings, associated dento-facial anomalies, and resulting treatment load.

OBJECTIVE: The purpose of this study was to report on the clinical, radiographic, and histological dental findings and the resulting treatment load in a five-generation family with amelogenesis imperfecta (AI). MATERIAL AND METHODS: Thirteen affected and 15 unaffected individuals were examined clinically and radiographically. In addition, four exfoliated deciduous teeth were examined by scanning electron microscopy and microradiography. RESULTS: The mode of inheritance of AI was autosomal-dominant. At eruption, most of the tooth enamel was yellow, lacking translucency, and prone to gradual loss in subjects with AI. Post-eruptive breakdown of enamel was extensive in accordance with the histological observations of hypomineralized and porous enamel. Extensive enamel loss and discoloration were observed in older affected individuals. The treatment need had been extensive: 76.2% of the total number of teeth present in affected individuals had been treated with partial or full coverage compared to 1.7% of the teeth in unaffected relatives. Unaffected individuals had more endodontically treated teeth than AI-affected relatives. Adjunctive findings, e.g. tooth agenesis, tooth impaction, pulp stones, enlarged follicular space, and taurodontism, were rare in both groups. CONCLUSIONS: Affected family members had the hypocalcified type of AI, which is characterized by severe hypomineralization, extensive post-eruptive loss, and discoloration of the enamel. Adjunctive findings were rare. Individuals with the hypocalcified type of AI have an extensive restorative treatment load compared to unaffected relatives.

Agenesis of permanent teeth in 8138 Danish schoolchildren: prevalence and intra-oral distribution according to gender.

OBJECTIVE: The purpose of this study was to describe agenesis of permanent teeth in children with respect to prevalence and intra-oral distribution according to gender. METHODS AND SUBJECTS: The study was population based and included all children in one district of the municipality of Aarhus, Denmark, in 1974-1979 (1657 girls and 1668 boys) and 1992-2002 (2409 girls and 2404 boys). The children underwent systematical clinical and radiographic examination. RESULTS: The period prevalence rates were almost identical for the two time periods (1972-1979: 7.8%; 1992-2002: 7.1%). Girls were affected more frequently than boys, and affected girls had more congenitally missing teeth than affected boys. Unilateral agenesis of the second premolars was more frequent than bilateral agenesis. In children with only one congenitally missing tooth, agenesis of the upper lateral incisors was asymmetrical in girls, but not in boys, whereas the opposite was true for the lower second premolars in boys. CONCLUSION: The prevalence of agenesis of permanent teeth in Danish schoolchildren seems to be constant over time, and similar to that found in other large, population-based studies. Intra-oral distributions of congenitally missing teeth indicate gender-specific patterns.

Dental anxiety among survivors of childhood cancer: a cross-sectional study.

BACKGROUND: Childhood cancer survivors may have experienced a high number of invasive medical and dental procedures which are known to be risk factors for dental anxiety. AIM: The aim of this study was to examine the prevalence of dental anxiety among children who have survived cancer. DESIGN: In a cross-sectional study, we examined 51 6- to 14-year-old children who had been treated for cancer at Aalborg Hospital, and 192 children without cancer. All children answered the Dental Subscale of the Children's Fear Survey Schedule. Dental anxiety was defined as a dental anxiety score exceeding the mean dental anxiety score + 1 standard deviation for the children without cancer. RESULTS: Children with cancer did not have an increased prevalence of dental anxiety compared with children without cancer: the prevalence ratio was 0.41 [95% confidence interval (CI): 0.10-1.24]. The mean dental anxiety score was 23.1 (95% CI: 21.2-25.0) among children who had been treated for cancer, and 24.7 (95% CI: 23.4-26.0) among children without cancer (mean difference: 1.6; 95% CI: 1.1-4.3). CONCLUSION: Cancer and cancer treatment during childhood were not associated with an increased risk of dental anxiety in this population.

Development of Danish version of child oral-health-related quality of life questionnaires (CPQ8-10 and CPQ11-14).

BACKGROUND: The Child Perceptions Questionnaire (CPQ) is a self-reported questionnaire developed to measure oral health-related quality of life in children. The CPQ aims to improve the description of children's oral health, while taking into consideration the importance of psychological aspects in the concept of health. The CPQ exists in two versions: the CPQ8-10 for children aged 8-10 years and the CPQ11-14 for those aged 11-14 years. The aim of this study was to develop a Danish version of the CPQ8-10 and the CPQ11-14 and to evaluate its validity for use among Danish-speaking children. METHODS: The instruments were translated from English into Danish in accordance with a recommended translation procedure. Afterwards, they were tested among children aged 8-10 (n = 120) and 11-14 years (n = 225). The validity was expressed by the correlation between overall CPQ scores and i) self-reported assessment of the influence of oral conditions on everyday life (not at all, very little, some, a lot, very much) and ii) the self-reported rating of oral health. Furthermore, groups of children with assumed decreased oral health-related quality of life were compared with children with healthy oral conditions. Finally, we examined the internal consistency. RESULTS: The correlation between overall CPQ scores and global assessments of the influence of oral conditions on everyday life showed Spearman correlation coefficients of 0.45, P < 0.001 for CPQ8-10 and 0.50, P < 0.001 for CPQ11-14. The correlation between overall CPQ scores and the self-reported rating of oral health showed Spearman correlation coefficients of 0.45, P < 0.001 for CPQ8-10 and 0.17, P = 0.010 for CPQ11-14.The median overall CPQ8-10 scores were 7 for individuals with healthy oral conditions, 5 for individuals with cleft lip and palate, and 15 for individuals with rare oral diseases. The median overall CPQ11-14 scores were 9 for individuals with healthy oral conditions, 9 for individuals with cleft lip and palate, 17.0 for individuals with rare oral diseases, and 22.0 for individuals with fixed orthodontic appliances. There were statistically significant differences between the groups of children with healthy oral conditions and each of the subgroups, except for children with cleft lip and palate.Chronbach'alpha were 0.82 for CPQ8-10 and 0.87 for CPQ11-14. CONCLUSION: The results of this study reveal that the Danish CPQ8-10 and CPQ11-14, seem to be valid instruments for measuring oral health-related quality of life in children although its ability to discriminate between children with cleft lip and palate and healthy children seem to be limited.