Detalhe da pesquisa
1.
Model studies towards prodrugs of the glutamine antagonist 6-diazo-5-oxo-l-norleucine (DON) containing a diazo precursor.
Bioorg Med Chem Lett
; 50: 128321, 2021 10 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-34400301
2.
MRI demonstrates glutamine antagonist-mediated reversal of cerebral malaria pathology in mice.
Proc Natl Acad Sci U S A
; 115(51): E12024-E12033, 2018 12 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-30514812
3.
Galactosyl Pentadecene Reversibly Enhances Transdermal and Topical Drug Delivery.
Pharm Res
; 34(10): 2097-2108, 2017 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-28664316
4.
Dodecyl Amino Glucoside Enhances Transdermal and Topical Drug Delivery via Reversible Interaction with Skin Barrier Lipids.
Pharm Res
; 34(3): 640-653, 2017 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-28070753
5.
Discovery of tert-Butyl Ester Based 6-Diazo-5-oxo-l-norleucine Prodrugs for Enhanced Metabolic Stability and Tumor Delivery.
J Med Chem
; 66(22): 15493-15510, 2023 11 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-37949450
6.
Glutamine Antagonist JHU-083 Normalizes Aberrant Hippocampal Glutaminase Activity and Improves Cognition in APOE4 Mice.
J Alzheimers Dis
; 77(1): 437-447, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-32675407
7.
Glutamine antagonism attenuates physical and cognitive deficits in a model of MS.
Neurol Neuroimmunol Neuroinflamm
; 6(6)2019 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-31467038
8.
JHU-083 selectively blocks glutaminase activity in brain CD11b+ cells and prevents depression-associated behaviors induced by chronic social defeat stress.
Neuropsychopharmacology
; 44(4): 683-694, 2019 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-30127344
9.
Correction: JHU-083 selectively blocks glutaminase activity in brain CD11b+ cells and prevents depression-associated behaviors induced by chronic social defeat stress.
Neuropsychopharmacology
; 44(6): 1178, 2019 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-30862949
10.
Glutamine blockade induces divergent metabolic programs to overcome tumor immune evasion.
Science
; 366(6468): 1013-1021, 2019 11 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-31699883
11.
Glutamine Antagonist JHU083 Normalizes Aberrant Glutamate Production and Cognitive Deficits in the EcoHIV Murine Model of HIV-Associated Neurocognitive Disorders.
J Neuroimmune Pharmacol
; 14(3): 391-400, 2019 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-31209775
12.
Discovery of Benzamidine- and 1-Aminoisoquinoline-Based Human MAS-Related G-Protein-Coupled Receptor X1 (MRGPRX1) Agonists.
J Med Chem
; 62(18): 8631-8641, 2019 09 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-31498617
13.
N-Substituted Prodrugs of Mebendazole Provide Improved Aqueous Solubility and Oral Bioavailability in Mice and Dogs.
J Med Chem
; 61(9): 3918-3929, 2018 05 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-29648826
14.
N-(Pivaloyloxy)alkoxy-carbonyl Prodrugs of the Glutamine Antagonist 6-Diazo-5-oxo-l-norleucine (DON) as a Potential Treatment for HIV Associated Neurocognitive Disorders.
J Med Chem
; 60(16): 7186-7198, 2017 08 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-28759224
15.
Correction to: Glutamine Antagonist JHU083 Normalizes Aberrant Glutamate Production and Cognitive Deficits in the EcoHIV Murine Model of HIV-Associated Neurocognitive Disorders.
J Neuroimmune Pharmacol
; 16(3): 693, 2021 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-33914277
16.
Medicinal applications of perfluoroalkylated chain-containing compounds.
Future Med Chem
; 6(10): 1201-29, 2014 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-25078138
17.
An approach to stereoselective preparation of 3-C-glycosylated D- and L-glucals.
Carbohydr Res
; 345(3): 352-62, 2010 Feb 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-20035928