Detalhe da pesquisa
1.
Ablation of specific long PDE4D isoforms increases neurite elongation and conveys protection against amyloid-ß pathology.
Cell Mol Life Sci
; 80(7): 178, 2023 Jun 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-37306762
2.
The Molecular Biology of Phosphodiesterase 4 Enzymes as Pharmacological Targets: An Interplay of Isoforms, Conformational States, and Inhibitors.
Pharmacol Rev
; 73(3): 1016-1049, 2021 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-34233947
3.
From methylation to myelination: epigenomic and transcriptomic profiling of chronic inactive demyelinated multiple sclerosis lesions.
Acta Neuropathol
; 146(2): 283-299, 2023 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-37286732
4.
Selective PDE4 subtype inhibition provides new opportunities to intervene in neuroinflammatory versus myelin damaging hallmarks of multiple sclerosis.
Brain Behav Immun
; 109: 1-22, 2023 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-36584795
5.
Soluble guanylyl cyclase: A novel target for the treatment of vascular cognitive impairment?
Pharmacol Res
; 197: 106970, 2023 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-37884069
6.
Biased 5-HT1A receptor agonists F13714 and NLX-101 differentially affect pattern separation and neuronal plasticity in rats after acute and chronic treatment.
Mol Cell Neurosci
; 120: 103719, 2022 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-35283305
7.
The value of maintaining cognition in patients with mild cognitive impairment: The innovation headroom and potential cost-effectiveness of roflumilast.
Alzheimers Dement
; 19(8): 3458-3471, 2023 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-36808801
8.
Computational investigation of the dynamic control of cAMP signaling by PDE4 isoform types.
Biophys J
; 121(14): 2693-2711, 2022 07 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-35717559
9.
DNA methylation regulates the expression of the negative transcriptional regulators ID2 and ID4 during OPC differentiation.
Cell Mol Life Sci
; 78(19-20): 6631-6644, 2021 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-34482420
10.
Roflumilast protects against spatial memory impairments and exerts anti-inflammatory effects after transient global cerebral ischemia.
Eur J Neurosci
; 53(4): 1171-1188, 2021 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-33340424
11.
Pharmacological inhibition of phosphodiesterase 7 enhances consolidation processes of spatial memory.
Neurobiol Learn Mem
; 177: 107357, 2021 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33278592
12.
Positive effects of roflumilast on behavior, neuroinflammation, and white matter injury in mice with global cerebral ischemia.
Behav Pharmacol
; 32(6): 459-471, 2021 09 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34320520
13.
Dietary plant stanol ester supplementation reduces peripheral symptoms in a mouse model of Niemann-Pick type C1 disease.
J Lipid Res
; 61(6): 830-839, 2020 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-32291331
14.
Persistence of the extinction of fear memory requires late-phase cAMP/PKA signaling in the infralimbic cortex.
Neurobiol Learn Mem
; 172: 107244, 2020 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-32376452
15.
Phosphodiesterase inhibitors roflumilast and vardenafil prevent sleep deprivation-induced deficits in spatial pattern separation.
Synapse
; 74(6): e22150, 2020 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-32056276
16.
Sphingosine-1-Phosphate Receptor Modulators and Oligodendroglial Cells: Beyond Immunomodulation.
Int J Mol Sci
; 21(20)2020 Oct 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-33066042
17.
Effects of DNA methyltransferase inhibition on pattern separation performance in mice.
Neurobiol Learn Mem
; 159: 6-15, 2019 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-30731235
18.
Gestational stress in mouse dams negatively affects gestation and postpartum hippocampal BDNF and P11 protein levels.
Mol Cell Neurosci
; 88: 292-299, 2018 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-29501719
19.
The phosphodiesterase type 2 inhibitor BAY 60-7550 reverses functional impairments induced by brain ischemia by decreasing hippocampal neurodegeneration and enhancing hippocampal neuronal plasticity.
Eur J Neurosci
; 45(4): 510-520, 2017 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-27813297
20.
Possible overlapping time frames of acquisition and consolidation phases in object memory processes: a pharmacological approach.
Learn Mem
; 23(1): 29-37, 2016 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-26670184