The Crossroads of the Coagulation System and the Immune System: Interactions and Connections.

The coagulation and immune systems, two vital systems in the human body, share intimate connections that fundamentally determine patient health. These systems work together through several common regulatory pathways, including the Tissue Factor (TF) Pathway. Immune cells expressing TF and producing pro-inflammatory cytokines can influence coagulation, while coagulation factors and processes reciprocally impact immune responses by activating immune cells and controlling their functions. These shared pathways contribute to maintaining health and are also involved in various pathological conditions. Dysregulated coagulation, triggered by infection, inflammation, or tissue damage, can result in conditions such as disseminated intravascular coagulation (DIC). Concurrently, immune dysregulation may lead to coagulation disorders and thrombotic complications. This review elucidates these intricate interactions, emphasizing their roles in the pathogenesis of autoimmune diseases and cancer. Understanding the complex interplay between these systems is critical for disease management and the development of effective treatments. By exploring these common regulatory mechanisms, we can uncover innovative therapeutic strategies targeting these intricate disorders. Thus, this paper presents a comprehensive overview of the mutual interaction between the coagulation and immune systems, highlighting its significance in health maintenance and disease pathology.

The New Therapeutic Strategies in Pediatric T-Cell Acute Lymphoblastic Leukemia.

Childhood acute lymphoblastic leukemia is a genetically heterogeneous cancer that accounts for 10-15% of T-cell acute lymphoblastic leukemia (T-ALL) cases. The T-ALL event-free survival rate (EFS) is 85%. The evaluation of structural and numerical chromosomal changes is important for a comprehensive biological characterization of T-ALL, but there are currently no genetic prognostic markers. Despite chemotherapy regimens, steroids, and allogeneic transplantation, relapse is the main problem in children with T-ALL. Due to the development of high-throughput molecular methods, the ability to define subgroups of T-ALL has significantly improved in the last few years. The profiling of the gene expression of T-ALL has led to the identification of T-ALL subgroups, and it is important in determining prognostic factors and choosing an appropriate treatment. Novel therapies targeting molecular aberrations offer promise in achieving better first remission with the hope of preventing relapse. The employment of precisely targeted therapeutic approaches is expected to improve the cure of the disease and quality of life of patients. These include therapies that inhibit Notch1 activation (bortezomib), JAK inhibitors in ETP-ALL (ruxolitinib), BCL inhibitors (venetoclax), and anti-CD38 therapy (daratumumab). Chimeric antigen receptor T-cell therapy (CAR-T) is under investigation, but it requires further development and trials. Nelarabine-based regimens remain the standard for treating the relapse of T-ALL.

Spatio-Temporal Mapping of L-Band Microwave Emission on a Heterogeneous Area with ELBARA III Passive Radiometer.

Water resources on Earth become one of the main concerns for society. Therefore, remote sensing methods are still under development in order to improve the picture of the global water cycle. In this context, the microwave bands are the most suitable to study land-water resources. The Soil Moisture and Ocean Salinity (SMOS), satellite mission of the European Space Agency (ESA), is dedicated for studies of the water in soil over land and salinity of oceans. The part of calibration/validation activities in order to improve soil moisture retrieval algorithms over land is done with ground-based passive radiometers. The European Space Agency L-band Microwave Radiometer (ELBARA III) located near the Bubnów wetland in Poland is capable of mapping microwave emissivity at the local scale, due to the azimuthal and vertical movement of the horn antenna. In this paper, we present results of the spatio-temporal mapping of the brightness temperatures on the heterogeneous area of the Bubnów test-site consisting of an area with variable organic matter (OM) content and different type of vegetation. The soil moisture (SM) was retrieved with the L-band microwave emission of the biosphere (L-MEB) model with simplified roughness parametrization (SRP) coupling roughness and optical depth parameters. Estimated soil moisture values were compared with in-situ data from the automatic agrometeorological station. The results show that on the areas with a relatively low OM content (4-6%-cultivated field) there was good agreement between measured and estimated SM values. Further increase in OM content, starting from approximately 6% (meadow wetland), caused an increase in bias, root mean square error (RMSE), and unbiased RMSE (ubRMSE) values and a general drop in correlation coefficient (R). Despite a span of obtained R values, we found that time-averaged estimated SM using the L-MEB SRP approach strongly correlated with OM contents.

The effect of land use change on transformation of relief and modification of soils in undulating loess area of East poland.

The change of primary forest areas into arable land involves the transformation of relief and modification of soils. In this study, we hypothesized that relatively flat loess area was largely transformed after the change of land use due to erosion. The modifications in soil pedons and distribution of soil properties were studied after 185 years of arable land use. Structure of pedons and solum depth were measured in 128 and soil texture and soil organic carbon in 39 points. Results showed that soils of noneroded and eroded profiles occupied 14 and 50%, respectively, and depositional soils 36% of the area. As a consequence, the clay, silt, and SOC concentration varied greatly in the plowed layer and subsoil. The reconstructed profiles of eroded soils and depositional soils without the accumulation were used to develop the map of past relief. The average inclination of slopes decreased from 4.3 to 2.2°, and slopes >5° vanished in the present topography. Total erosion was 23.8 Mg ha(-1) year(-1). From that amount, 88% was deposited within the study area, and 12% was removed outside. The study confirmed the hypothesis of the significant effect of the land use change on relief and soils in loess areas.

Radon emission fluctuation as a result of biochar application into the soil.

The presented research was focused on the analysis of the impact of biochar application into the soil on the radon exhalation process as a new issue of radiation protection in agriculture. Field measurements of the radon exhalation rate utilizing two methods-active and passive as well as laboratory measurements of the radon emanation coefficient were performed. In laboratory a soil samples with sunflower husk biochar were analysed using the accumulation chamber technique. At the final step the assessment of the effective dose for humans coming from radon exhalation from soil depending on biochar dose applied were evaluated. The doses of biochar applied in the analysed experimental fields were 0, 20, 40, 60, 80, and 100 Mg ha-1. The results show that biochar application into the soil contribute to a decrease in the emanation coefficient from a value around 7% to less than 2% with a simultaneous decrease in the radon exhalation rate from 4.4 to 14.8 mBq m-2 s-1 when the biochar dose increase from 0 to 100 Mg ha-1.

Effect of Fine Size-Fractionated Sunflower Husk Biochar on Water Retention Properties of Arable Sandy Soil.

Biochar application has been reported to improve the physical, chemical, and hydrological properties of soil. However, the information about the size fraction composition of the applied biochar as a factor that may have an impact on the properties of soil-biochar mixtures is often underappreciated. Our research shows how sunflower husk biochar (pyrolyzed at 650 °C) can modify the water retention characteristics of arable sandy soil depending on the biochar dose (up to 9.52 wt.%) and particle size (<50 µm, 50-100 µm, 100-250 µm). For comparison, we used soil samples mixed with biochar passed through 2 mm sieve and an unamended reference. The addition of sieved biochar to the soil caused a 30% increase in the available water content (AWC) in comparing to the soil without biochar. However, the most notable improvement (doubling the reference AWC value from 0.078 m3 m-3 to 0.157 m3 m-3) was observed at the lowest doses of biochar (0.95 and 2.24 wt.%) and for the finest size fractions (below 100 µm). The water retention effects on sandy soil are explained as the interplay between the dose, the size of biochar particles, and the porous properties of biochar fractions.

Impact of soil incorporation of biochar on environmental radioactivity.

Biochar (charcoal made from biomass in the pyrolysis process) has found broad application in agriculture. It helps to improve both the physical and chemical properties of soil through decontamination of heavy metals and pesticides. This work examines the potential for biochar application to improve the radiological condition of soil. We investigated the activity concentration of natural and anthropogenic radionuclides in soil samples collected from fields treated with various doses of biochar (in 1-100 Mg ha-1 ). In addition, we directly measured radon emission rate at the experimental fields. The analyses were performed using gamma spectrometry and an active method for radon emission using an AlphaGUARD instrument equipped with an accumulation box. The results of activity concentration assessments for six radionuclides, five natural and one anthropogenic, show that the only effect of biochar application into the soil is associated with the reduction of soil bulk density by this material. The radon emission rate increased by 6 mBq m-1 s-1 , on average, depending on the biochar dose (from 1 to 100 Mg ha-1 ). Our results demonstrate that application of biochar into soil kept without vegetation had a limited influence on the radioactivity in the environment.