Detalhe da pesquisa
1.
Small-molecule inhibitors targeting Polycomb repressive complex 1 RING domain.
Nat Chem Biol
; 17(7): 784-793, 2021 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-34155404
2.
Covalent inhibition of NSD1 histone methyltransferase.
Nat Chem Biol
; 16(12): 1403-1410, 2020 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-32868895
3.
Combinatorial treatment with menin and FLT3 inhibitors induces complete remission in AML models with activating FLT3 mutations.
Blood
; 136(25): 2958-2963, 2020 12 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-33331926
4.
The same site on the integrase-binding domain of lens epithelium-derived growth factor is a therapeutic target for MLL leukemia and HIV.
Blood
; 124(25): 3730-7, 2014 Dec 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-25305204
5.
Structural insights into inhibition of the bivalent menin-MLL interaction by small molecules in leukemia.
Blood
; 120(23): 4461-9, 2012 Nov 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-22936661
6.
Menin-MLL inhibitors reverse oncogenic activity of MLL fusion proteins in leukemia.
Nat Chem Biol
; 8(3): 277-84, 2012 Jan 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-22286128
7.
Combination of menin and kinase inhibitors as an effective treatment for leukemia with NUP98 translocations.
Leukemia
; 2024 Jun 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-38890447
8.
EWS-FLI1 and Menin Converge to Regulate ATF4 Activity in Ewing Sarcoma.
Mol Cancer Res
; 19(7): 1182-1195, 2021 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-33741715
9.
Discovery of first-in-class inhibitors of ASH1L histone methyltransferase with anti-leukemic activity.
Nat Commun
; 12(1): 2792, 2021 05 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-33990599
10.
Collagen fragmentation promotes oxidative stress and elevates matrix metalloproteinase-1 in fibroblasts in aged human skin.
Am J Pathol
; 174(1): 101-14, 2009 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-19116368
11.
Covalent and noncovalent constraints yield a figure eight-like conformation of a peptide inhibiting the menin-MLL interaction.
Eur J Med Chem
; 207: 112748, 2020 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32882610
12.
Menin inhibitor MI-3454 induces remission in MLL1-rearranged and NPM1-mutated models of leukemia.
J Clin Invest
; 130(2): 981-997, 2020 02 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-31855575
13.
Complexity of Blocking Bivalent Protein-Protein Interactions: Development of a Highly Potent Inhibitor of the Menin-Mixed-Lineage Leukemia Interaction.
J Med Chem
; 61(11): 4832-4850, 2018 06 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-29738674
14.
Smad3-dependent CCN2 mediates fibronectin expression in human skin dermal fibroblasts.
PLoS One
; 12(3): e0173191, 2017.
Artigo
em Inglês
| MEDLINE | ID: mdl-28267785
15.
Theoretical models of inhibitory activity for inhibitors of protein-protein interactions: targeting menin-mixed lineage leukemia with small molecules.
Medchemcomm
; 8(12): 2216-2227, 2017 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29456828
16.
Property Focused Structure-Based Optimization of Small Molecule Inhibitors of the Protein-Protein Interaction between Menin and Mixed Lineage Leukemia (MLL).
J Med Chem
; 59(3): 892-913, 2016 Feb 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-26744767
17.
Rational Design of Orthogonal Multipolar Interactions with Fluorine in Protein-Ligand Complexes.
J Med Chem
; 58(18): 7465-74, 2015 Sep 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-26288158
18.
Pharmacologic inhibition of the Menin-MLL interaction blocks progression of MLL leukemia in vivo.
Cancer Cell
; 27(4): 589-602, 2015 Apr 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-25817203
19.
High-affinity small-molecule inhibitors of the menin-mixed lineage leukemia (MLL) interaction closely mimic a natural protein-protein interaction.
J Med Chem
; 57(4): 1543-56, 2014 Feb 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-24472025
20.
Smad3-dependent regulation of type I collagen in human dermal fibroblasts: Impact on human skin connective tissue aging.
J Dermatol Sci
; 83(1): 80-3, 2016 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-27132061