Pesquisa | Portal de Pesquisa da BVS Enfermagem

1.

Biology of factor XI.

Moellmer, Samantha A; Puy, Cristina; McCarty, Owen J T.

Blood ; 143(15): 1445-1454, 2024 Apr 11.

Artigo em Inglês | MEDLINE | ID: mdl-37874916

2.

Factor XI Inhibition for the Prevention of Catheter-Associated Thrombosis in Patients With Cancer Undergoing Central Line Placement: A Phase 2 Clinical Trial.

Pfeffer, Michael A; Kohs, Tia C L; Vu, Helen H; Jordan, Kelley R; Wang, Jenny Si Han; Lorentz, Christina U; Tucker, Erik I; Puy, Cristina; Olson, Sven R; DeLoughery, Thomas G; Hinds, Monica T; Keshari, Ravi S; Gailani, David; Lupu, Florea; McCarty, Owen J T; Shatzel, Joseph J.

Arterioscler Thromb Vasc Biol ; 44(1): 290-299, 2024 01.

Artigo em Inglês | MEDLINE | ID: mdl-37970718

3.

Factor XI as a therapeutic target in neuroinflammatory disease.

Taskin, Berk; Kohs, Tia C L; Shatzel, Joseph J; Puy, Cristina; McCarty, Owen J T.

Curr Opin Hematol ; 31(1): 32-38, 2024 Jan 01.

Artigo em Inglês | MEDLINE | ID: mdl-37694771

4.

Targeting the Contact Pathway of Coagulation for the Prevention and Management of Medical Device-Associated Thrombosis.

Goel, Abhishek; Tathireddy, Harsha; Wang, Si-Han; Vu, Helen H; Puy, Cristina; Hinds, Monica T; Zonies, David; McCarty, Owen J T; Shatzel, Joseph J.

Semin Thromb Hemost ; 2023 Apr 12.

Artigo em Inglês | MEDLINE | ID: mdl-37044117

5.

Substrates, Cofactors, and Cellular Targets of Coagulation Factor XIa.

Lira, André L; Kohs, Tia C L; Moellmer, Samantha A; Shatzel, Joseph J; McCarty, Owen J T; Puy, Cristina.

Semin Thromb Hemost ; 2023 Mar 20.

Artigo em Inglês | MEDLINE | ID: mdl-36940715

6.

Factor XII plays a pathogenic role in organ failure and death in baboons challenged with Staphylococcus aureus.

Silasi, Robert; Keshari, Ravi S; Regmi, Girija; Lupu, Cristina; Georgescu, Constantin; Simmons, Joe H; Wallisch, Michael; Kohs, Tia C L; Shatzel, Joseph J; Olson, Sven R; Lorentz, Christina U; Puy, Cristina; Tucker, Erik I; Gailani, David; Strickland, Sidney; Gruber, András; McCarty, Owen J T; Lupu, Florea.

Blood ; 138(2): 178-189, 2021 07 15.

Artigo em Inglês | MEDLINE | ID: mdl-33598692

7.

Cross-Talk between the Complement Pathway and the Contact Activation System of Coagulation: Activated Factor XI Neutralizes Complement Factor H.

Puy, Cristina; Pang, Jiaqing; Reitsma, Stéphanie E; Lorentz, Christina U; Tucker, Erik I; Gailani, David; Gruber, András; Lupu, Florea; McCarty, Owen J T.

J Immunol ; 206(8): 1784-1792, 2021 04 15.

Artigo em Inglês | MEDLINE | ID: mdl-33811105

8.

Role of platelets in regulating activated coagulation factor XI activity.

Reitsma, Stéphanie E; Pang, Jiaqing; Raghunathan, Vikram; Shatzel, Joseph J; Lorentz, Christina U; Tucker, Erik I; Gruber, András; Gailani, David; McCarty, Owen J T; Puy, Cristina.

Am J Physiol Cell Physiol ; 320(3): C365-C374, 2021 03 01.

Artigo em Inglês | MEDLINE | ID: mdl-33471623

9.

Endothelial PAI-1 (Plasminogen Activator Inhibitor-1) Blocks the Intrinsic Pathway of Coagulation, Inducing the Clearance and Degradation of FXIa (Activated Factor XI).

Puy, Cristina; Ngo, Anh T P; Pang, Jiaqing; Keshari, Ravi S; Hagen, Matthew W; Hinds, Monica T; Gailani, David; Gruber, András; Lupu, Florea; McCarty, Owen J T.

Arterioscler Thromb Vasc Biol ; 39(7): 1390-1401, 2019 07.

Artigo em Inglês | MEDLINE | ID: mdl-31242030

10.

Contact Activation Inhibitor and Factor XI Antibody, AB023, Produces Safe, Dose-Dependent Anticoagulation in a Phase 1 First-In-Human Trial.

Lorentz, Christina U; Verbout, Norah G; Wallisch, Michael; Hagen, Matthew W; Shatzel, Joseph J; Olson, Sven R; Puy, Cristina; Hinds, Monica T; McCarty, Owen J T; Gailani, David; Gruber, András; Tucker, Erik I.

Arterioscler Thromb Vasc Biol ; 39(4): 799-809, 2019 04.

Artigo em Inglês | MEDLINE | ID: mdl-30700130

11.

The Safety and Efficacy of Novel Agents Targeting Factors XI and XII in Early Phase Human Trials.

DeLoughery, Emma P; Olson, Sven R; Puy, Cristina; McCarty, Owen J T; Shatzel, Joseph J.

Semin Thromb Hemost ; 45(5): 502-508, 2019 Jul.

Artigo em Inglês | MEDLINE | ID: mdl-31216587

12.

Factor XII Activation Promotes Platelet Consumption in the Presence of Bacterial-Type Long-Chain Polyphosphate In Vitro and In Vivo.

Zilberman-Rudenko, Jevgenia; Reitsma, Stéphanie E; Puy, Cristina; Rigg, Rachel A; Smith, Stephanie A; Tucker, Erik I; Silasi, Robert; Merkulova, Alona; McCrae, Keith R; Maas, Coen; Urbanus, Rolf T; Gailani, David; Morrissey, James H; Gruber, András; Lupu, Florea; Schmaier, Alvin H; McCarty, Owen J T.

Arterioscler Thromb Vasc Biol ; 38(8): 1748-1760, 2018 08.

Artigo em Inglês | MEDLINE | ID: mdl-30354195

13.

Activated protein C inhibits neutrophil extracellular trap formation in vitro and activation in vivo.

Healy, Laura D; Puy, Cristina; Fernández, José A; Mitrugno, Annachiara; Keshari, Ravi S; Taku, Nyiawung A; Chu, Tiffany T; Xu, Xiao; Gruber, András; Lupu, Florea; Griffin, John H; McCarty, Owen J T.

J Biol Chem ; 292(21): 8616-8629, 2017 05 26.

Artigo em Inglês | MEDLINE | ID: mdl-28408624

14.

Activated factor XI increases the procoagulant activity of the extrinsic pathway by inactivating tissue factor pathway inhibitor.

Puy, Cristina; Tucker, Erik I; Matafonov, Anton; Cheng, Qiufang; Zientek, Keith D; Gailani, Dave; Gruber, András; McCarty, Owen J T.

Blood ; 125(9): 1488-96, 2015 Feb 26.

Artigo em Inglês | MEDLINE | ID: mdl-25587039

15.

Utility of microfluidic devices to study the platelet-endothelium interface.

Zilberman-Rudenko, Jevgenia; Sylman, Joanna L; Garland, Kathleen S; Puy, Cristina; Wong, Andrew D; Searson, Peter C; McCarty, Owen J T.

Platelets ; 28(5): 449-456, 2017 Jul.

Artigo em Inglês | MEDLINE | ID: mdl-28358586

16.

Factor XII inhibition reduces thrombus formation in a primate thrombosis model.

Matafonov, Anton; Leung, Philberta Y; Gailani, Adam E; Grach, Stephanie L; Puy, Cristina; Cheng, Qiufang; Sun, Mao-Fu; McCarty, Owen J T; Tucker, Erik I; Kataoka, Hiroaki; Renné, Thomas; Morrissey, James H; Gruber, Andras; Gailani, David.

Blood ; 123(11): 1739-46, 2014 Mar 13.

Artigo em Inglês | MEDLINE | ID: mdl-24408325

17.

sPLA2-V inhibits EPCR anticoagulant and antiapoptotic properties by accommodating lysophosphatidylcholine or PAF in the hydrophobic groove.

López-Sagaseta, Jacinto; Puy, Cristina; Tamayo, Ibai; Allende, Mikel; Cerveró, Jorge; Velasco, Susana E; Esmon, Charles T; Montes, Ramón; Hermida, José.

Blood ; 119(12): 2914-21, 2012 Mar 22.

Artigo em Inglês | MEDLINE | ID: mdl-22167755

18.

Pharmacologic targeting of coagulation factors XII and XI by monoclonal antibodies reduces thrombosis in nitinol stents under flow.

Keeling, Novella M; Wallisch, Michael; Johnson, Jennifer; Le, Hillary H; Vu, Helen H; Jordan, Kelley R; Puy, Cristina; Tucker, Erik I; Nguyen, Khanh P; McCarty, Owen J T; Aslan, Joseph E; Hinds, Monica T; Anderson, Deirdre E J.

J Thromb Haemost ; 22(5): 1433-1446, 2024 May.

Artigo em Inglês | MEDLINE | ID: mdl-38331196

19.

Activation of coagulation FXI promotes endothelial inflammation and amplifies platelet activation in a nonhuman primate model of hyperlipidemia.

Kohs, Tia C L; Vu, Helen H; Jordan, Kelley R; Parra-Izquierdo, Iván; Hinds, Monica T; Shatzel, Joseph J; Kievit, Paul; Morgan, Terry K; Yunga, Samuel Tassi; Ngo, Thuy T M; Aslan, Joseph E; Wallisch, Michael; Lorentz, Christina U; Tucker, Erik I; Gailani, David; Lindner, Jonathan R; Puy, Cristina; McCarty, Owen J T.

Res Pract Thromb Haemost ; 8(1): 102276, 2024 Jan.

Artigo em Inglês | MEDLINE | ID: mdl-38226339

20.

Revised model of the tissue factor pathway of thrombin generation: Role of the feedback activation of FXI.

Lakshmanan, Hari Hara Sudhan; Estonilo, Aldrich; Reitsma, Stéphanie E; Melrose, Alexander R; Subramanian, Jayaram; Zheng, Tony J; Maddala, Jeevan; Tucker, Erik I; Gailani, David; McCarty, Owen J T; Jurney, Patrick L; Puy, Cristina.

J Thromb Haemost ; 20(6): 1350-1363, 2022 06.

Artigo em Inglês | MEDLINE | ID: mdl-35352494

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