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AIM: To evaluate the effect of noiiglutide as an adjunct to lifestyle intervention on the reduction in body weight and tolerability in obese Chinese adults without diabetes. MATERIALS AND METHODS: In this 24-week, randomized, double-blind, placebo-controlled phase 2 trial, 254 obese adults with a body mass index of 28.0-40.0 kg/m2 and without diabetes were enrolled. Participants were initially randomized in a 1:1:1 ratio to one of three dose levels: 0.12, 0.24, or 0.36 mg of the study treatment. Within each dose level, participants were further randomized in a 3:1 ratio to receive either subcutaneous injection of noiiglutide or a matching placebo. The primary endpoint was the change in body weight from baseline to week 24. RESULTS: Across all noiiglutide dosage levels, least squares mean reductions in body weight from baseline to week 24 ranged from 8.03 to 8.50 kg, compared with 3.65 kg in the placebo group (all p-values <.0001). In the noiiglutide groups (0.12, 0.24, 0.36 mg/day), a significantly higher proportion of participants achieved a weight loss ≥5% (68.8%, 60.0%, 73.0%) and ≥10% (37.5%, 36.9%, 39.7%), compared with the pooled placebo group (≥5%: 29.0%; ≥10%: 8.1%). Gastrointestinal adverse events, such as nausea, diarrhoea and vomiting, were more common in all noiiglutide groups (15.4%-30.2%, 18.8%-22.2%, 15.6%-18.5%) than in the pooled placebo group (8.1%, 6.5%, 0%). CONCLUSIONS: In obese Chinese adults without diabetes, once-daily subcutaneous noiiglutide significantly reduced body week at week 24 compared with placebo, and had a manageable safety profile, primarily involving gastrointestinal disorders.
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Diabetes Mellitus Tipo 2 , Hipoglicemiantes , Adulto , Humanos , Hipoglicemiantes/uso terapêutico , Peso Corporal , Obesidade/complicações , Obesidade/tratamento farmacológico , Obesidade/induzido quimicamente , Diabetes Mellitus Tipo 2/complicações , Diabetes Mellitus Tipo 2/tratamento farmacológico , Diabetes Mellitus Tipo 2/induzido quimicamente , Injeções Subcutâneas , China/epidemiologia , Método Duplo-Cego , Resultado do TratamentoRESUMO
Aquaculture is one of the fastest growing sectors in global food production, recognized as a significant contributor to poverty alleviation, food security, and income generation. However, the frequent occurrence of diseases caused by pathogen infections result in reduced yields and economic losses, posing a substantial constraint to the sustainable development of aquaculture. Here, our study identified that four catechol compounds, quercetin, luteolin, caffeic acid, and chlorogenic acid, exhibited potent antiparasitic effects against Ichthyophthirius multifiliis in both, in vitro and in vivo. The parasite is recognized as one of the most pathogenic to fish worldwide. Using a combination of in silico methods, the dipeptidyl peptidase (DPP) was identified as a critical target for catechol compounds. The two hydroxyl radicals of the catechol group were essential for its binding to and interacting with the DPP protein. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses indicated that catechol compounds disrupt pathways associated with the metabolism and growth of I. multifiliis, thereby exerting antiparasitic effects. Furthermore, these compounds attenuated the expression of proinflammatory cytokines in vivo in fish and promoted macrophage polarization toward M2 phenotype by inhibiting the STAT1 signaling pathway. The dual activity of catechol compounds, acting as both direct antiparasitic and anti-inflammatory agents in fish, offers a promising therapeutic approach for combating I. multifiliis infections in aquaculture.
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Catecóis , Infecções por Cilióforos , Doenças dos Peixes , Hymenostomatida , Animais , Doenças dos Peixes/imunologia , Doenças dos Peixes/parasitologia , Doenças dos Peixes/prevenção & controle , Hymenostomatida/efeitos dos fármacos , Catecóis/farmacologia , Infecções por Cilióforos/veterinária , Infecções por Cilióforos/imunologia , Infecções por Cilióforos/parasitologia , Infecções por Cilióforos/prevenção & controle , Antiparasitários/farmacologiaRESUMO
The circular economy (CE) aims to decouple the growth of the economy from the consumption of finite resources through strategies, such as eliminating waste, circulating materials in use, and regenerating natural systems. Due to the rapid development of data science (DS), promising progress has been made in the transition toward CE in the past decade. DS offers various methods to achieve accurate predictions, accelerate product sustainable design, prolong asset life, optimize the infrastructure needed to circulate materials, and provide evidence-based insights. Despite the exciting scientific advances in this field, there still lacks a comprehensive review on this topic to summarize past achievements, synthesize knowledge gained, and navigate future research directions. In this paper, we try to summarize how DS accelerated the transition to CE. We conducted a critical review of where and how DS has helped the CE transition with a focus on four areas including (1) characterizing socioeconomic metabolism, (2) reducing unnecessary waste generation by enhancing material efficiency and optimizing product design, (3) extending product lifetime through repair, and (4) facilitating waste reuse and recycling. We also introduced the limitations and challenges in the current applications and discussed opportunities to provide a clear roadmap for future research in this field.
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Ciência de Dados , Gerenciamento de Resíduos , ReciclagemRESUMO
The severe water scarcity in China poses significant economic risks to its agriculture, energy, and manufacturing sectors, which can have a cascading effect through the supply chains. Current research has assessed water scarcity losses for global countries and Chinese provinces by using the water scarcity risk (WSR) method. However, this method involves subjective functions and parameter settings, and it fails to capture the adaptive behaviors of economies to water scarcity, compromising the reliability of quantified water scarcity loss. There is a pressing need for a new method to assess losses related to water scarcity. Here, we develop an agent-based complex network model to estimate the inter-regional and intersectoral impacts of water scarcity on both cities and basins. Subsequently, we evaluate the supply chain-wide economic benefits of four different water conservation measures as stipulated by the 14th Five-Year Plan for the Construction of a Water-Saving Society. These measures include increasing the utilization rate of recycled water in water-scarce cities, reducing the national water consumption per industrial value-added, and implementing agricultural and residential water conservation measures. Results show that direct losses constitute only 9% of the total losses from water scarcity. Approximately 37% of the losses can be attributed to interregional impacts. Among the water-scarce cities, Qingdao, Lanzhou, Jinan, and Zhengzhou pose a significant threat to China's supply chains. Agricultural water conservation yields the highest amount of water savings and economic benefits, while residential water conservation provides the highest economic benefit per unit of water saved. The results provide insights into managing water scarcity, promoting cross-regional cooperation, and mitigating economic impacts.
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Conservação dos Recursos Hídricos , Abastecimento de Água , Reprodutibilidade dos Testes , Insegurança Hídrica , China , Agricultura , ÁguaRESUMO
OBJECTIVE: An alterable risk factor for hyperuricemia is obesity. Additionally, obese people may have a moderate form of acquired resistance to thyroid hormones. Thyrotropin, thyroid hormones, and obesity all interact subtly. However, the connection between thyroid hormone sensitivity and hyperuricemia in obese patients both before and after laparoscopic sleeve gastrectomy (LSG) has not yet been clarified. The objective of our study was to investigate the connection between impaired thyroid hormone sensitivity and elevated uric acid (UA) levels before and after LSG. METHODS: In total, 1054 euthyroid patients with obesity (481 males, 573 females), 248 (143 female patients) of whom underwent subsequent LSG, were enrolled in this retrospective study. Anthropometric measurements and thyroid hormone and UA levels were taken before and 3 months after LSG. RESULTS: Female patients with obesity with impaired sensitivity to thyroid hormones had higher UA levels (P for trend <.01). The odds ratio of the fourth vs first quartile of thyroid feedback quantile index, thyrotropin index, and thyrotropin-thyroxine resistance index were 4.285 (confidence interval: 1.360-13.507), 3.700 (confidence interval: 1.276-10.729), and 2.839 (confidence interval: 1.014-7.948), respectively, with robust relationships with female hyperuricemia (all P < .05). However, there was only a positive correlation between the decline in UA levels and thyroid feedback quantile index, thyrotropin, and thyrotropin-thyroxine resistance index in female patients following LSG. CONCLUSION: Female hyperuricemia is correlated with higher thyroid hormone resistance index scores. Resistance to thyroid hormones was greatly improved by LSG. The decrease in UA levels after surgery is correlated with the improvement of thyroid hormone resistance after LSG.
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Gastrectomia , Laparoscopia , Obesidade , Hormônios Tireóideos , Ácido Úrico , Humanos , Feminino , Adulto , Gastrectomia/métodos , Ácido Úrico/sangue , Estudos Retrospectivos , Pessoa de Meia-Idade , Obesidade/cirurgia , Obesidade/sangue , Obesidade/complicações , Masculino , Hormônios Tireóideos/sangue , Tireotropina/sangue , Hiperuricemia/sangue , Hiperuricemia/epidemiologia , Obesidade Mórbida/cirurgia , Obesidade Mórbida/sangueRESUMO
BACKGROUND: Obesity is associated with elevated serum uric acid (SUA) levels and frequent gout flares. Losing weight can reduce the SUA level and gout flares. The effect of orlistat on SUA levels and gout flares in patients with overweight/obesity and hyperuricemia (HUA) has not been extensively studied. This study investigated the effects of orlistat on SUA levels and gout flares compared to placebo in overweight and obese patients with HUA. METHODS: A total of 72 Chinese patients with overweight/obesity and HUA were randomly divided into a placebo group (35, 48.6%) and an orlistat group (37, 51.4%); the trial lasted 12 weeks. The primary endpoints were the relative changes in body weight, the SUA level, and gout flares in the per-protocol population. RESULTS: Orlistat reduced the proportion of patients with gout flares (log-rank P = 0.023, hazard ratio = 0.31, 95% confidence interval 0.11-0.85). There was no significant difference in SUA level between the two groups. The average weight loss of the orlistat group was 2.85 kg, and the average weight loss of the placebo group was 0.76 kg. The weight loss in the orlistat group was significantly greater than that in the control group (P < 0.05). CONCLUSIONS: This study is the first to demonstrate that orlistat has no significant effect on SUA levels in patients with overweight/obesity and HUA. The utility of orlistat as an adjunct therapy to prevent gout flares during weight loss in patients with HUA was emphasized. TRIAL REGISTRATION: Clinicaltrials.gov NCT05496075.
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Hiperuricemia , Orlistate , Sobrepeso , Humanos , Masculino , Método Duplo-Cego , Gota/complicações , Gota/tratamento farmacológico , Hiperuricemia/complicações , Hiperuricemia/tratamento farmacológico , Obesidade/complicações , Obesidade/tratamento farmacológico , Orlistate/efeitos adversos , Sobrepeso/complicações , Sobrepeso/tratamento farmacológico , Ácido Úrico , Redução de PesoRESUMO
BACKGROUND: The main purpose of this paper is to introduce a method that can accurately locate the posterior capsule of the lens to facilitate a relatively complete resection of the anterior vitreous body. METHODS: A total of 51 patients in the experimental group and control group were enrolled in this study. Phacoemulsification combined with vitrectomy was performed in all cases. After the cataract procedure was completed in the control group, the surgeon performed a conventional anterior vitrectomy with the operative eye. In the experimental group, anterior vitrectomy was performed according to the threadiness corrugation of the posterior capsule of the lens. During the operation, with the help of triamcinolone, two surgeons confirmed the resection of the anterior vitreous cortex; the best corrected visual acuity and intraocular pressure of all patients were recorded at 1 week, 1 month and 3 months after surgery. RESULTS: Fifty patients underwent phacoemulsification combined with vitrectomy, except one patient in the experimental group who was lost to follow-up. After surgery, no significant complications were observed in all patients except two patients in the control group with temporary increases in intraocular pressure. There was no significant difference in preoperative visual acuity between the two groups (t = 0.83, P = 0.25). Both groups had varying degrees of improvement in best corrected visual acuity at 1 week, 1 month and 3 months after surgery. Moreover, there was no significant difference in BCVA between the two groups at the three follow-up time points (t=-1.15, -1.65, -1.09, P = 0.53, 0.21, 0.23). After surgery, no significant complications were observed in all patients except two patients in the control group with temporary increases in intraocular pressure. Incomplete resection of the anterior vitreous cortex was observed in 2 patients in each group, but there was no significant difference (χ2 = 7.81, P > 0.05). CONCLUSION: In the process of cataract surgery combined with vitrectomy, thready corrugation appears in the posterior capsule of the lens and is an important sign of its localization. Anterior vitrectomy can be accomplished safely and effectively with the help of thread-like corrugation, and the surgical effect is almost the same as that of traditional surgery. Especially suitable for beginners in vitreous surgery.
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Pressão Intraocular , Facoemulsificação , Acuidade Visual , Vitrectomia , Corpo Vítreo , Humanos , Vitrectomia/métodos , Facoemulsificação/métodos , Feminino , Masculino , Idoso , Pessoa de Meia-Idade , Corpo Vítreo/cirurgia , Pressão Intraocular/fisiologia , Cápsula Posterior do Cristalino/cirurgia , Idoso de 80 Anos ou maisRESUMO
The 2030 agenda of the United Nations provides a framework of 17 Sustainable Development Goals (SDGs) and 232 indicators for its members to fulfill. The overall achievement critically depends on how nations understand the interactions between these SDGs and set priorities for development pathways. This study provides a comprehensive network analysis of global SDG complementarities, measured by the co-occurrences of SDG pairs' comparative advantages in the same region by adopting the 'product space' concept from economics. We construct the 'SDG space' at goal and indicator levels with the most recently available data and then validate its robustness by comparing it to the commonly used correlation network and confirm its predictive power using historical data. Network analysis reveals a strongly connected socioeconomic-related core and an environmental-related periphery, with 'bridge' indicators connecting different clusters. The goal-level space identifies the 'bridge' goals as SDG 17 (Partnerships for the Goals), SDG 8 (Decent Work and Economic Growth), and SDG 15 (Life on Hand) in the environmental-related cluster, while identifying SDG 7 (Affordable and Clean Energy), SDG 6 (Clean water and Sanitation), and SDG 16 (Justice and Strong Institutions) in the socioeconomic cluster. The indicator-level space provides details to explain how they act as 'bridges' in the network. In particular, 16-9: Free Press Index is the 'bridge' indicator with the highest betweenness centrality value and acts as the bottleneck indicator in China for its overall sustainable development. Improving it can enhance connected indicators' performance, leading to positive cascading effects on different aspects of sustainability.
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Saúde Global , Desenvolvimento Sustentável , Desenvolvimento Econômico , China , ÁguaRESUMO
Dual control policies aim to effectively reduce energy consumption and carbon emission by setting targets for total volume and intensity control. With global climate change becoming increasingly serious. China, as a large energy-consuming and carbon-emitting country, faces a huge challenge to reduce carbon emissions. The transition from the "dual control of energy consumption" to the "dual control of carbon emissions" in China is necessary to optimize energy structures, promote energy conservation, reduce carbon emissions, and reach carbon neutrality. This study utilizes multi-regional input-output models to evaluate the results toward both goals from production-based, consumption-based, and income-based perspectives. The findings indicate that "dual control of carbon emissions" is a more precise approach than "dual control of energy consumption". Some provinces have met the latter goal while still falling short of the former. Provinces having met their production-based energy intensity and carbon emission intensity targets, but having failed their consumption-based and income-based targets, are identified to develop a comprehensive and accurate assessment of these targets. A net outflow of embodied energy and carbon emissions is observed among provinces in less-developed central and southern regions to more-developed eastern and northern regions. Suggestions and policy implications based on these findings include establishing a comprehensive evaluation of energy and carbon intensity, considering both consumption-based and income-based perspectives, as well as facilitating enhanced cooperation among developed and developing provinces.
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Carbono , Mudança Climática , ChinaRESUMO
Bariatric surgery (BS) has been a significant means of reducing weight in obese individuals. The metabolic changes after bariatric surgery are crucial as they extend its advantages beyond weight loss. As its name implies, "metabolic surgery" also addresses obesity-related metabolic concerns. Bariatric surgery has always been associated with lessened serum uric acid (SUA) levels. In this review, we examined current studies to understand how surgical therapies impact serum uric acid levels. Strongly minded on the extent and timing of changes in the level of serum uric acid after bariatric surgeries. We conducted a comprehensive search for relevant current studies in PubMed, Google Scholar, JAMA, and the Cochrane Library until February 1, 2024. We aimed to analyze the metabolic advantages of bariatric surgery, focusing on its function in treating hyperuricemia and lowering the risk of associated disorders. Our review elaborates on factors contributing to decreased serum uric acid levels after bariatric surgery, such as alterations in renal function, insulin sensitivity, and inflammatory markers.
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Rare earth elements (REEs) have been used as tracers to reveal the hydrochemical sources and processes in groundwater systems that are usually modified by anthropogenic inputs. However, the REE behaviors in groundwater affected by mining activities have yet to be fully understood. In combination of REE geochemistry with general hydrochemical and isotopic (δ2H and δ18O) methods, this study investigated the concentration and fractionation of REEs in alkaline groundwater from two coal mines with similar aquifer lithology but different mining histories in the Northern Ordos Basin. One of the coal mines started mining in March 2009 (Ningtiaota coal mine, NTT), while the other started mining in December 2018 (Caojiatan coal mine, CJT). Results show that the primary hydrochemical type is HCO3-Ca in NTT groundwater with pH value ranging between 7.68 and 8.60, while CJT groundwater was dominated by the HCO3-Na type with higher pH of 9.09-10.00. The average values of ΣREEs were lower, and the NASC-normalized pattern reflected more intense fractionation in NTT groundwater than those in CJT groundwater. The evident differences are caused by the distinctions in water-rock interaction, complexation of inorganic species, and adsorption of REEs in NTT and CJT groundwater. Furthermore, these processes were closely related to the pH of groundwater that was different in two coal mines, which is likely linked to the different durations of coal mining activities that led to differences in development of rock fractures and pyrite oxidation. It is expected that REEs, combined with other indicators such as pH, can be used to trace and help better understand the hydrochemical changes in groundwater caused by mining.
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Minas de Carvão , Água Subterrânea , Metais Terras Raras , Poluentes Químicos da Água , Monitoramento Ambiental/métodos , Poluentes Químicos da Água/análise , Mineração , Metais Terras Raras/análise , China , Carvão Mineral/análiseRESUMO
Background: Ultrasound (US) has a high sensitivity in detecting monosodium urate (MSU) deposition in gout patients. However, the value of US in predicting gout flares has been reported only in a few monocentric studies. Objective: To investigate the association between gout flares in the previous year and US-detected MSU burden using two different US scores. Design: A retrospective study. Methods: Patients with gout were consecutively recruited to undergo musculoskeletal US examinations of their knees, ankles, and feet. The score derived from Outcome Measure in Rheumatology (hereinafter referred to as MSU score) and musculoskeletal US features-based (hereinafter referred to as MSKF score) were used to quantify the MSU burden of gout. Odds ratios for frequent gout flares were calculated. Results: We enrolled 1894 patients with gout (mean age: 45 years; gout duration: 5 years; males: 96.1%), experiencing a median of three flares over the past year. Of these, 428 (22.6%) patients reported frequent (⩾7) gout flares. The MSU and MSKF median scores were 6 and 9, respectively. For each five-point increase in MSU and MSKF score, the odds ratio of frequent gout flares increased 1.13-fold and 1.24-fold, respectively. The area under the curve (AUC) for the MSU and MSKF score was 0.635 [95% confidence interval (CI): 0.604-0.665] and 0.688 (95% CI: 0.659-0.718), respectively, (AUC difference 0.054, p value for AUC difference < 0.001). Conclusion: The MSU and MSKF scores were significantly associated with the number of gout flares in the previous year. The MSKF score outperformed the MSU score in terms of frequent gout flare discrimination.
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BACKGROUND: Kidney stones and thyroid disease are two common diseases in the general population, with multiple common risk factors. The associations between kidney stones and thyroid disease are unclear. AIM: This study aims to assess the association between 'once had a thyroid disease' and the odds of kidney stones. METHODS: Adult participants from the National Health and Nutrition Examination Survey (NHANES) 2007-2018 with reliable kidney stone and thyroid disease data were included. Adjusting for age, gender, race, education level, and marital status, diabetes, hypertension, gout, angina pectoris, stroke, and asthma, logistic regression was used to examine the relationship between kidney stones and thyroid illness. RESULTS: Using stratified analysis, the association between thyroid illness and kidney stones was investigated further. Among the participants, 4.9% had kidney stones, and 10.1% had thyroid disease. Kidney stone was associated with thyroid disease (OR=1.441, (95% CI:1.294-1.604), p <0.01), which remained significant (OR=1.166, (95% CI:1.041-1.305), p <0.01) after adjustments with age, gender, race, education level and marital status, diabetes, hypertension, gout, angina pectoris, stroke, and asthma. Stratified by blood lead, blood cadmium, and blood urea nitrogen levels in the human body, the odds of kidney stones still increased with once having a previous thyroid disease. CONCLUSIONS: In this large nationally representative survey over 10 years, kidney stone was strongly associated with thyroid disease. In this cross-sectional study, we explored the association between thyroid disease and kidney stones, which may help clinicians intervene in them early.
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The anterior gradient protein 2 (AGR2) plays a crucial role in facilitating the formation of protein disulfide bonds within the endoplasmic reticulum (ER). Research suggests that AGR2 can function as an oncogene, with its heightened expression linked to the advancement of hepatobiliary and pancreatic cancers through invasion and metastasis. Notably, AGR2 not only serves as a pro-oncogenic agent but also as a downstream targeting protein, indirectly fostering cancer progression. This comprehensive review delves into the established functions and expression patterns of AGR2, emphasizing its pivotal role in cancer progression, particularly in hepatobiliary and pancreatic malignancies. Furthermore, AGR2 emerges as a potential cancer prognostic marker and a promising target for immunotherapy, offering novel avenues for the treatment of hepatobiliary and pancreatic cancers and enhancing patient outcomes.
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Mucoproteínas , Proteínas Oncogênicas , Neoplasias Pancreáticas , Humanos , Mucoproteínas/metabolismo , Mucoproteínas/genética , Neoplasias Pancreáticas/genética , Neoplasias Pancreáticas/metabolismo , Neoplasias Pancreáticas/terapia , Neoplasias Pancreáticas/tratamento farmacológico , Neoplasias Pancreáticas/patologia , Proteínas Oncogênicas/metabolismo , Proteínas Oncogênicas/genética , Neoplasias Hepáticas/genética , Neoplasias Hepáticas/metabolismo , Neoplasias Hepáticas/terapia , Neoplasias Hepáticas/patologia , Animais , Neoplasias do Sistema Biliar/genética , Neoplasias do Sistema Biliar/metabolismo , Neoplasias do Sistema Biliar/tratamento farmacológico , Neoplasias do Sistema Biliar/terapia , Neoplasias do Sistema Biliar/patologia , Regulação Neoplásica da Expressão Gênica , Biomarcadores Tumorais/metabolismo , Biomarcadores Tumorais/genéticaRESUMO
Population-normalized indicators (e.g., GDP per capita), under the assumption of the indicators scaling linearly with population, are ubiquitously used in national development performance comparison. This assumption, however, is not valid because it may ignore agglomeration effect resulting from nonlinear interactions in socioeconomic systems. Here, we present extensive empirical evidence showing the sub-linear scaling rather than the presumed linear scaling between population and multiple indicators of national development performance. We then develop a theoretical framework based on the scaling rule observed in cities to explore the origin of scaling in countries. Finally, we demonstrate that urbanization plays a pivotal role in transforming national development from limited sub-linear growth to unlimited super-linear growth. This underscores the significance of urbanization in achieving sustained growth and elevating human living standards at the national level. Our findings have the potential to inform policies aimed at promoting equitable inter-country comparison and achieving sustainable development in countries.
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The water quality evolution of surface and groundwater caused by mining activities and mine drainage is a grave public concern worldwide. To explore the effect of mine drainage on sulfate evolution, a multi-aquifer system in a typical coal mine in Northwest China was investigated using multi-isotopes (δ34SSO4, δ18OSO4, δD, and δ18Owater) and Positive Matrix Factorization (PMF) model. Before mining, the Jurassic aquifer was dominated by gypsum dissolution, accompanied by cation exchange and bacterial sulfate reduction, and the phreatic aquifers and surface water were dominated by carbonate dissolution. Significant increase in sulfate in phreatic aquifers due to mine drainage during the early stages of coal mining. However, in contrast to common mining activities that result in sulfate contamination from pyrite oxidation, mine drainage in this mining area resulted in accelerated groundwater flow and enhanced hydraulic connections between the phreatic and confined aquifers. Dilution caused by the altered groundwater flow system controlled the evolution of sulphate, leading to different degrees of sulfate decrease in all aquifers and surface water. As the hydrogeochemical characteristic of Jurassic aquifer evolved toward phreatic aquifer, this factor should be considered to avoid misjudgment in determining the source of mine water intrusion. The study reveals the hydrogeochemical evolution induced by mine drainage, which could benefit to the management of groundwater resources in mining areas.
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Monitoramento Ambiental , Água Subterrânea , Sulfatos , Poluentes Químicos da Água , Água Subterrânea/química , Sulfatos/análise , Poluentes Químicos da Água/análise , China , Minas de Carvão , Movimentos da Água , MineraçãoRESUMO
Fouling is a significant challenge for recycling and reusing saline wastewaters for industrial, agricultural or municipal applications. In this study, we propose a novel approach of magnetic field (MaF) and ultraviolet (UV) combined application for fouling mitigation. Results showed, combination of MaF and UV (MaF-UV) significantly decreased the content of biofouling and reduced the complexity of microbial networks, compared to UV and MaF alone treatments. This was due to MaF as pretreatment effectively reduced the water turbidity, improve the influent water quality of UV disinfection and increases UV transmittance, eliminating the adverse impacts of UV scattering and shielding, hence increased the inactivation effectiveness of UV disinfection process. MaF assisted UV also reduced the abundance of UV-resistant bacteria and inhibited the risk of bacterial photoreactivation and dark repair. Meanwhile, MaF-UV drastically reduced the contents of precipitates and particulate fouling by accelerating the transformation rate of CaCO3 crystal from compact calcite to loosen hydrated amorphous CaCO3, and enhancing the flocculation process. These findings demonstrated that MaF-UV is an effective anti-fouling strategy, and provide insights for sustainable application of saline wastewaters.
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Águas Residuárias , Purificação da Água , Raios Ultravioleta , Bactérias , Desinfecção/métodos , Agricultura , Purificação da Água/métodosRESUMO
PURPOSE: To investigate the impact of body mass index (BMI) on the aggressiveness of papillary thyroid cancer (PTC). METHODS: A total of 1720 PTC patients with total thyroidectomy or lobectomy, from January 2017 to April 2020, were retrospectively evaluated. Based on BMI, they were divided into two groups, as follows: control (CON, < 24 kg/m2) and overweight and obesity (OB, ≥ 24 kg/m2), each sex being analyzed separately. RESULTS: In the whole cohort, the OB group had significantly higher rates of extrathyroidal extension (21.5 vs. 16.8%, p = 0.013), multifocality (43.2 vs. 37.7%, p = 0.018), and BRAF-V600E mutation (82.9 vs. 79.3%, p = 0.015) than the CON group. In males, the OB group had increased rates of tumor size over 1cm (54.4 vs. 42.7%, p = 0.008), extrathyroidal extension (24.9 vs. 12.4%, p = 0.001), and multifocality (42.7 vs. 33.5%, p = 0.038). The OB group had significantly higher adjusted odds ratios (ORs) of 1.63 (1.14-2.33, p = 0.008), 2.12 (1.26-3.57, p = 0.005), and 1.56 (1.07-2.29, p = 0.022) for tumor size over 1cm, extrathyroidal extension, and multifocality compared with CON. Additionally, overweight and obesity were analyzed alone and the rates of extrathyroidal extension (30/100, 30.0%, p = 0.001) and tumor size over 1cm (65/100, 65.0%, p = 0.001) were significantly higher in the obesity group than in the overweight and CON groups. The obesity group had robust higher adjusted ORs of 2.51(1.50-4.20, p < 0.001), 2.93 (1.50-5.73, p = 0.002) and 1.89 (1.11-3.22, p = 0.020) for tumor size over 1cm, extrathyroidal extension, and multifocality compared with CON. CONCLUSIONS: Overweight and obesity were predominant independent risk factors for PTC aggressiveness in males. These data indicated that the therapeutic treatment should be based on risk stratification by BMI in males.
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Obesidade , Câncer Papilífero da Tireoide , Neoplasias da Glândula Tireoide , Humanos , Masculino , Câncer Papilífero da Tireoide/patologia , Obesidade/complicações , Feminino , Neoplasias da Glândula Tireoide/patologia , Pessoa de Meia-Idade , Adulto , Estudos Retrospectivos , Índice de Massa Corporal , Fatores Sexuais , TireoidectomiaRESUMO
Recent phenomena such as pandemics, geopolitical tensions, and climate change-induced extreme weather events have caused transportation network interruptions, revealing vulnerabilities in the global supply chain. A salient example is the March 2021 Suez Canal blockage, which delayed 432 vessels carrying cargo valued at $92.7 billion, triggering widespread supply chain disruptions. Our ability to model the spatiotemporal ramifications of such incidents remains limited. To fill this gap, we develop an agent-based complex network model integrated with frequently updated maritime data. The Suez Canal blockage is taken as a case study. The results indicate that the effects of such blockages go beyond the directly affected countries and sectors. The Suez Canal blockage led to global losses of about $136.9 ($127.5-$147.3) billion, with India suffering 75% of these losses. Global losses show a nonlinear relationship with the duration of blockage and exhibit intricate trends post blockage. Our proposed model can be applied to diverse blockage scenarios, potentially acting as an early-alert system for the ensuing supply chain impacts. Furthermore, high-resolution daily data post blockage offer valuable insights that can help nations and industries enhance their resilience against similar future events.
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Groundwater salinization, a major eco-environmental problem in arid and semi-arid areas, can accelerate soil salinization, reducing crop productivity and imbalances in ecosystem diversity. This study classified water samples collected from the Ulansuhai Lake basin into five clusters using self-organizing maps (SOM). On this basis, multiple isotopes (δ18Owater, δD, 87Sr/86Sr, δ18Osulfate and δ34S) and isotopic models (Rayleigh fractionation and Bayesian isotope mixing models) were used to identify and quantify the genesis and evolution of groundwater salinization. The results showed that the samples were brackish or saline water, and the hydrochemical types were dominated by Na + K-Cl (SO4). It has been proved that the processes associated with groundwater salinization in the Ulansuhai Lake basin were dominated by water-rock interaction and human inputs. Among them, evaporite dissolution contributed substantially to groundwater salinity. Furthermore, salt inputs from human activities cannot be negligible. Based on the model calculations, evaporite dissolution accounted for the most significant proportion of all sources, with a mean value of 53 %. In addition, human inputs from regular agricultural activities (28 % from sewage and manure and 8 % from fertilizers) constituted another vital source of groundwater salinization associated with extensive agricultural activities in the study area. This study's results can deepen our understanding of the genesis of groundwater salinization and the evolution of the agricultural drainage lake basin. This knowledge will assist the Environmental Protection Department in developing effective policies for groundwater management in the Yellow River Basin.